Prehľadný článok sa zaoberá niektorými aspektami histórie warfarínu a jeho použitia spočiatku ako rodenticídu a neskôr ako antikoagulancia. Sú popísané jeho základné fyzikálno-chemické vlastnosti a schematicky rozobrané možnosti prípravy selektívnou i neselektívnou syntézou z derivátov kumarínu. Je uvedený tabuľkový prehľad syntéz a ich výsledkov s literárnymi odkazmi a záver článku tvorí zhodnotenie perspektív tohto liečiva s porovnaním s alternatívnymi antikoagulanciami a zhodnotené sú ich výhody, nevýhody a perspektívy.
The review paper deals with some aspects of warfarin history and its use, at the beginning as a rodenticide and later as an anticoagulant. It describes its principal physical-chemical properties and it analyzes schematically the possibilities of its preparation by both selective and non-selective synthesis from coumarin derivatives. A survey of syntheses and its results are tabulated, including the literary references, and the paper is concluded with an evaluation of the prospects of this agent in comparison with alternative anticoagulants and its advantages, disadvantages and prospects.
- MeSH
- 4-Hydroxycoumarins chemistry MeSH
- Antidotes contraindications MeSH
- Adult MeSH
- Factor Xa administration & dosage therapeutic use MeSH
- Fibrin administration & dosage therapeutic use MeSH
- Factor Xa Inhibitors MeSH
- Hemorrhage MeSH
- Drug Interactions MeSH
- Humans MeSH
- Drug Monitoring MeSH
- Primary Prevention MeSH
- Risk Factors MeSH
- Secondary Prevention MeSH
- Traumatology methods MeSH
- Thromboembolism drug therapy prevention & control MeSH
- Warfarin administration & dosage pharmacokinetics chemical synthesis chemistry adverse effects therapeutic use MeSH
- Check Tag
- Adult MeSH
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
