Cíl: Předkládaná případová studie si klade za cíl zodpovědět otázku: "Jak ovlivňuje psychoterapeutický program své respondenty?" Sledovaný psychoterapeutický program je určen lidem se zkušeností s duševní poruchou, spadá do komunitní psychiatrické péče. Zkoumaný psychoterapeutický program může být alternativou hospitalizace na psychiatrii nebo na hospitalizaci přímo navazuje, případně má i preventivní charakter. Metody: Byly využity jak kvantitativní, tak kvalitativní metody a techniky, přičemž respondenti byli monitorováni jeden rok. Konkrétně byla data získávána prostřednictvím zúčastněného pozorování, z terénních poznámek, analýzou dokumentů a pomocí dotazníku SIS (Social Integration Survey), jenž byl přeložen z anglického originálu za spolupráce vedoucí autorského týmu Výzkumného ústavu Piedmont Dr. Jane Scott-Lennox. Výsledky: Program má pozitivní vliv na zlepšení komunikace, aktivizaci, zvýšení informovanosti, ve smyslu porozumění nemoci, léčbě, sebepoznání a náhledu s respektem k individuálním možnostem respondentů. Z hlediska zotavení dodává naději, přispívá k rozvoji a udržení kompetencí a dovedností, podporuje zplnomocnění a obnovení sociálních rolí. Závěr: Získaná data potvrdila, že účast na psychoterapeutickém programu přispívá k sociální integraci členů.

Objective: The case study aims at answering the following question: "What are the effects of a psychotherapeutic programme on its participants?" The psychotherapeutic programme under examination is intended for people with severe mental illness (SMI) experience and falls under community psychiatric care. The psychotherapeutic programme subject to this research can be an alternative to, or directly follow after, psychiatric hospitalisation, or can also be preventive. Methods: Both quantitative and qualitative methods and techniques were used; the participants were monitored over a period of one year. More specifically, data were obtained through participant observation, field notes, by analysing documents and using the SIS (Social Integration Survey) questionnaire, which was translated from the English original in co-operation with Dr. Jane Scott-Lennox, head of the team of authors at the Piedmont Research Institute. Results: The programme has a positive effect on improving communication, activation and increasing awareness in the sense of understanding the illness, treatment, self-discovery and insight, while respecting the participants' individual potential. In terms of recovery, it gives hope, contributes to developing and maintaining competences and skills, and promotes empowerment and restoration of social roles. Conclusions: The data obtained have confirmed that participation in a psychotherapeutic programme contributes to the participants' social integration.

This article is focused on the application of two types of docking software, AutoDock and DOCK. It is aimed at studying the interactions of a calcium-dependent bacterial lectin PA-IIL (from Pseudomonas aeruginosa) and its in silico mutants with saccharide ligands. The effect of different partial charges assigned to the calcium ions was tested and evaluated in terms of the best agreement with the crystal structure. The results of DOCK were further optimized by molecular dynamics and rescored using AMBER. For both software, the agreement of the docked structures and the provided binding energies were evaluated in terms of prediction accuracy. This was carried out by comparing the computed results to the crystal structures and experimentally determined binding energies, respectively. The performance of both docking software applied on a studied problem was evaluated as well. The molecular docking methods proved efficient in identifying the correct binding modes in terms of geometry and partially also in predicting the preference changes caused by mutation. Obtaining a reasonable in silico method for the prediction of lectin-saccharide interactions may be possible in the future.

• MeSH
• Adhesins, Bacterial genetics   chemistry   MeSH
• Financing, Organized MeSH
• Informatics MeSH
• Protein Structure, Quaternary MeSH
• Lectins genetics   chemistry   MeSH
• Ligands MeSH
• Models, Molecular MeSH
• Molecular Sequence Data MeSH
• Monosaccharides chemistry   MeSH
• Mutagenesis, Site-Directed statistics & numerical data   MeSH
• Computer Simulation MeSH
• Pseudomonas aeruginosa genetics   chemistry   MeSH
• Amino Acid Sequence MeSH
• Sequence Homology, Amino Acid MeSH
• Software MeSH
• Thermodynamics MeSH
• Calcium chemistry   MeSH
• Binding Sites genetics   MeSH

The new version of the TRITON program provides user-friendly graphical tools for modeling protein mutants using the external program MODELLER and for docking ligands into the mutants using the external program AutoDock. TRITON can now be used to design ligand-binding proteins, to study protein-ligand binding mechanisms or simply to dock any ligand to a protein. Availability: Executable files of TRITON are available free of charge for academic users at http://ncbr.chemi.muni.cz/triton/

• MeSH
• Algorithms MeSH
• Models, Chemical MeSH
• Financing, Organized MeSH
• Ligands MeSH
• Models, Molecular MeSH
• Computer Graphics MeSH
• Computer Simulation MeSH
• Protein Engineering methods   MeSH
• Proteins chemistry   ultrastructure   MeSH
• Drug Design MeSH
• Software MeSH
• User-Computer Interface MeSH
• Protein Binding MeSH
• Binding Sites MeSH

We study the estimation of statistical moments of interspike intervals based on observation of spike counts in many independent short time windows. This scenario corresponds to the situation in which a target neuron occurs. It receives information from many neurons and has to respond within a short time interval. The precision of the estimation procedures is examined. As the model for neuronal activity, two examples of stationary point processes are considered: renewal process and doubly stochastic Poisson process. Both moment and maximum likelihood estimators are investigated. Not only the mean but also the coefficient of variation is estimated. In accordance with our expectations, numerical studies confirm that the estimation of mean interspike interval is more reliable than the estimation of coefficient of variation. The error of estimation increases with increasing mean interspike interval, which is equivalent to decreasing the size of window (less events are observed in a window) and with decreasing the number of neurons (lower number of windows).

• MeSH
• Algorithms MeSH
• Financing, Organized MeSH
• Models, Neurological MeSH
• Neurons physiology   MeSH

• MeSH
• Affinity Labels metabolism   MeSH
• Research Support as Topic MeSH
• Fucose genetics   metabolism   MeSH
• Galactose genetics   metabolism   MeSH
• Lectins genetics   chemistry   MeSH
• Humans MeSH
• Mutagenesis genetics   MeSH
• Pseudomonas aeruginosa metabolism   MeSH
• Ralstonia solanacearum metabolism   MeSH
• Computational Biology methods   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Virulence Factors MeSH
• Lectins biosynthesis   MeSH
• Mutagenesis MeSH
• Pseudomonas aeruginosa pathogenicity   MeSH
• Structure-Activity Relationship MeSH

• MeSH
• Domestic Violence legislation & jurisprudence   MeSH
• Child Advocacy MeSH
• Family MeSH
• Legislation as Topic MeSH
• Child Abuse legislation & jurisprudence   MeSH

• Conspectus
• Soukromé právo
• NML Fields
• lidská práva
• právo, zákonodárství
• sociologie
• NML Publication type
• informační publikace
• právní předpisy

• Publication type
• Meeting Abstract MeSH

Nejobsáhlejší a univerzální příručka k přípravě na přijímací zkoušky napsaná zkušenými vysokoškolskými pedagogy. Vypracování testových otázek ze všech humanitních oborů nezbytné pro úspěšné složení zkoušek, doplněné informacemi a radami, jak se připravovat.

Cílem projektu je vypracování a praktické ověření programu obrazové analýzy pro měření obsahu DNA a AgNORů jader buněk nádorů kostí,štítné žlázy,mammy a plic. XXX XXX XXX

• MeSH
• Diagnostic Imaging MeSH
• Neoplasm Staging methods   MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• onkologie
• radiologie, nukleární medicína a zobrazovací metody
• chemie, klinická chemie
• NML Publication type
• závěrečné zprávy o řešení grantu IGA MZ ČR