Úvod: Studie je zaměřena na zhodnocení klinických výsledků kombinovaného preparátu obsahujícího beta-trikalcium fosfát a kalcium sulfát pro léčbu parodontálních vnitrokostních defektů. Kombinace těchto materiálů dává předpoklad pro vyšší efekt řízené tkáňové regenerace při její aplikaci právě díky vlastnostem této kombinace. Materiál a metodika: V práci jsou hodnotící výsledky léčby u 47 zubů s intrakostními defekty celkem u 26 pacientů. U všech byl použit preparát Fortoss® Vital (Biocomposites, Stafordshire, Velká Británie). Byly hodnoceny klinické parametry, což zahrnuje zjišťování změn hloubky parodontálních chobotů, úroveň gingivodentálního spojení, tedy pokles či nárůst (clinical attachement level) gingiválních recesů na začátku ošetření a po dvou letech od ošetření. Výsledky a závěr: Průměrnou změnou po dvou letech od ošetření byla redukce hloubky parodontálních chobotů o 2,07 ± 1,14 mm (p = 0,000), nárůstek u gingivo-dentálního spojení o 1,93 mm ± 1,36 mm (p = 0,000) a změna gingiválních recesů o 0,14 ± 0,73 mm (p = 0,571). Výsledky této studie ukázaly, že léčba kombinací beta-trikalcium fosfátem a kalcium sulfátem signifikantně zlepšuje pozitivní klinické výsledky u intraoseálních defektů i po dvou letech po chirurgickém ošetření.
Background: The study was designed to evaluate the clinical results of a composite material beta-tricalcium phosphate in combination with calcium sulphate in the treatment of periodontal intrabony defects. The combination of these materials is believed to aid in guieded tissue regeneration owing to their properties. Material and methods: A total of 47 teeth with intrabony defectsin in 26 periodontitis patiens were treated with Forthoss® Vital (Biocomposites, Staffordshiere, UK). Clinical parameters were evaluated included changes in probing depth, clinical attachement levels loss and gingival recession at the baseline and two years postoperatively. Results and conslusion: The mean in differences in mesurements between the baseline and two years postoperatively were a reduction of 2.07 ± 0.14 mm (p = 0.000) in case of probing depth and gain of 1.93 ± 1.36 mm (p = 0.000) in clinical attachement level; but an increase of 0.14 ± 0.73 mm (p = 0.571) in gingival recession. The study results showing that the treatment with the combination of beta-tricalcium phosphate and calcium phosphate and calcium sulphate led to a significantly favorable clinical improvement in periodontal intrabony defects two years after the surgery.
- Keywords
- retrospektivní průkaz, intraoseální defekt, beta-trikalcium fosfát,
- MeSH
- Biocompatible Materials therapeutic use MeSH
- Adult MeSH
- Calcium Phosphates * therapeutic use MeSH
- Bone Substitutes classification therapeutic use MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Periodontal Pocket therapy MeSH
- Periodontitis surgery therapy MeSH
- Bone Regeneration MeSH
- Guided Tissue Regeneration, Periodontal * MeSH
- Calcium Sulfate * therapeutic use MeSH
- Oral Surgical Procedures methods MeSH
- Bone Transplantation MeSH
- Treatment Outcome MeSH
- Dental Materials * classification therapeutic use MeSH
- Tooth physiopathology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Cíl práce: Cílem práce bylo zjištění poklesu hloubky parodontálních chobotů, jak hluboké choboty přetrvávají po tomto ošetření. Dalším účelem bylo dozvědět se, zda dochází k ústupu gingivy a v jakém stupni. Byla hodnocena i úroveň gingivodentálního spojení před ošetřením a po jednom roce. Metodika: Do studie bylo zařazeno 21 pacientů; všichni prošli iniciální fází, spolupracovali výborně, věk se pohyboval mezi 21 až 53 lety. Soubor tvořilo osm mužů a 13 žen. U 21 vyšetřených bylo do šetření zařazeno 39 zubů s hloubkou parodontálních chobotů ≥ 5 mm po iniciální terapii. Měřeny byly gingivální recesy před ošetřením a po ošetření. Zaznamenány byly hodnoty BOP. Na rtg snímcích byla resorpce kosti. Pacienti byli celkově zdraví, neužívali poslední tři měsíce antibiotika ani léky ovlivňující krevní srážlivost. Vyloučeny byly těhotné ženy. Zuby byly vitální nebo řádně endodonticky ošetřeny. Výsledky: Počet chobotů po chirurgickém výkonu poklesl ve všech měřeních. Největší stupeň ústupu gingivy byl vestibulárně. Největší pokles hloubky parodontálních chobotů byl meziálně a distálně (detaily viz tabulka).
Aim of study: The study was focused on the decrease of the depth of periodontal pockets and to obtain the information about depth of pockets after this type of treatment. Another result was to have information if there are recessions of soft tissues and the grade of recessions. Also the attachement level was evaluated before and one year after treatment. Method: 21 patients were includuded to the study, all of them passed through inicial phase, collaboration was on very good level. Age between 21–53 yers. Set of patients was composed by eight men and 13 women. For further treatment of 39 teeth with pocket depth ≥ 5 mm after inicial therapy was recomended GTR. Recessions were measured before and after treatment. Also were registered values of BOP. X-ray pictures confirmed bone resorption. All patients were generaly healthy, last three months no medication by antibiotics or anticoagulation drugs. No women were pregnant. Teeth were vital or correctly endodontic treated. Results: The study confirmed decrease of the number of teeth with pockets in all measurements. Conspicious decrease of pocket depth was registered on aproximal sides it means mesialy and distaly. We registered more noteceable recession on vestibular sides.
- Keywords
- kalcium sulfát,
- MeSH
- Dental Implantation, Endosseous * MeSH
- Phosphates therapeutic use MeSH
- Humans MeSH
- Oral Hygiene MeSH
- Periodontal Pocket * diagnostic imaging surgery therapy MeSH
- Periodontitis MeSH
- Retrospective Studies MeSH
- Gingival Retraction Techniques MeSH
- Bone Transplantation methods MeSH
- Gingival Recession therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
The study was designed to evaluate the clinical outcome of a composite material, beta-tricalcium phosphate in combination with calcium sulphate, in the treatment of periodontal intrabony defects. The combination of these materials is believed to aid in guided tissue regeneration owing to their properties. A total of 47 teeth with intrabony defects in 26 periodontitis patients were treated with Fortoss® Vital (Biocomposites, Staffordshire, UK). Clinical parameters were evaluated which included changes in probing depth, clinical attachment level/loss and gingival recession at the baseline and 2 years postoperatively. The mean differences in measurements between the baseline and 2 years postoperatively were a reduction of 2.07±1.14 mm (p=0.000) in case of probing depth and a gain of 1.93±1.36 mm (p=0.000) in clinical attachment level; but an increase of 0.14±0.73 mm (p=0.571) in gingival recession. The study results show that the treatment with a combination of beta tricalcium phosphate and calcium sulphate led to a significantly favorable clinical improvement in periodontal intrabony defects 2 years after the surgery.
- MeSH
- Biocompatible Materials administration & dosage MeSH
- Adult MeSH
- Financing, Organized MeSH
- Calcium Phosphates administration & dosage MeSH
- Bone Substitutes administration & dosage MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Periodontitis complications therapy MeSH
- Alveolar Bone Loss complications therapy MeSH
- Guided Tissue Regeneration, Periodontal MeSH
- Calcium Sulfate administration & dosage MeSH
- Dental Materials therapeutic use MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
OBJECTIVE: Oral lichen planus (OLP) is one of the commonest diseases of the oral mucosa. The etiology of the disease is unknown. Our goal was to determine frequencies of functionally important alleles which determine the metabolic rate (phenotype) of individuals with OLP and to compare drug utilization, with focus on CYP2D6, with that of a control group. MATERIAL AND METHODS: The study population consisted of 46 patients with OLP, 60 sex- and age-matched control subjects for drug utilization evaluation and 223 healthy non-medicated controls for genotype comparison. DNA analysis was done using polymerase chain reaction and restriction fragment length polymorphism. The gene CYP2D6 was analyzed for the alleles CYP2D6*3,*4,*5,*6 and gene duplication. Drug utilization was evaluated according to Anatomical Therapeutic Chemical code, liver drug metabolism pathway and mono- or polytherapy. RESULTS: Intake of drugs was significantly higher in the group of OLP patients in comparison with control subjects. The use of CYP2D6 substrates, inhibitors or inducers did not differ between OLP patients and controls. Predicted phenotype frequencies in OLP patients and healthy controls, respectively were as follows: ultrarapid metabolizers 2% and 5.8%, extensive metabolizers 52% and 49.8%, intermediate metabolizers 39% and 37.7% and poor metabolizers 7% and 6.7%. CONCLUSIONS: We did not find a statistically significant difference in the frequency of CYP2D6 alleles between OLP patients and healthy controls. OLP patients used more medication than age- and sex-matched controls.
- MeSH
- Alleles MeSH
- Cytochrome P-450 CYP2D6 genetics metabolism MeSH
- Gene Duplication MeSH
- Liver enzymology MeSH
- Lichen Planus, Oral enzymology genetics pathology MeSH
- Humans MeSH
- Polymerase Chain Reaction MeSH
- Polymorphism, Restriction Fragment Length MeSH
- Polypharmacy MeSH
- Aged MeSH
- Drug Utilization MeSH
- Case-Control Studies MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Alloplastic bone graft materials are widely been used in combination with barrier membranes to achieve guided tissue regeneration in the treatment of periodontal intrabony defects. This study was designed to evaluate the clinical outcome of a composite material, beta tricalcium phosphate in combination with calcium sulphate in the treatment of periodontal intrabony defects. The combination of these materials is believed to aid in guided tissue regeneration owing to their properties. Thirty nine intrabony defects in 21 patients were treated with Fortoss® Vital (Biocomposites, Staffordshire, UK). Clinical parameters were evaluated including changes in probing depth, clinical attachment level/loss and gingival recession at baseline and one year postoperatively. The mean differences in measurements between the baseline and one year postoperatively are a reduction of 1.98±1.16 mm (p=0.000) in case of probing depth and a gain of 1.68±1.12 mm (p=0.000) in clinical attachment level and an increase of 0.31±0.67 mm (p=0.009) in gingival recession measurements. The study results show that the treatment with a combination of beta tricalcium phosphate and calcium sulphate led to a significantly favorable clinical improvement in periodontal intrabony defects one year postoperatively.
- MeSH
- Biocompatible Materials administration & dosage MeSH
- Financing, Organized MeSH
- Calcium Phosphates administration & dosage MeSH
- Bone Substitutes administration & dosage MeSH
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Periodontal Diseases diagnosis therapy MeSH
- Alveolar Bone Loss therapy MeSH
- Guided Tissue Regeneration, Periodontal MeSH
- Calcium Sulfate administration & dosage MeSH
- Dental Materials MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
This article is limited to a review of bone replacement graft materials used in periodontal therapy. The source, mode of bone regeneration and the respective advantages and disadvantages of autogenous, allogenic, xenogenic and alloplastic materials are discussed.
- MeSH
- Bone Substitutes MeSH
- Humans MeSH
- Periodontal Diseases surgery MeSH
- Bone Transplantation MeSH
- Check Tag
- Humans MeSH
Two maxillary first molars and two central incisor typhodont teeth were prepared with 0.8 mm chamfer, 2.0 mm occlusal reduction, and 6 degree taper. The prepared teeth were duplicated 9 times to obtain 36 die stone models and divided into three groups (n = 12). Luting agents tested were zinc phosphate, glass ionomer and resin cement. Procera®AllCeram 0.6 mm coping was fixed with a calibrated finger force of 50 N. The absolute marginal discrepancy was measured using the scanning electron microscope on four axial walls with 4 measurements on each wall to obtain a total of 16 readings for one tooth. Mann Whitney U test was applied to find significant differences between luting cements and Kruskal Wallis tests among groups. Results The absolute marginal discrepancies of cements were in reducing order zinc phosphate (AZ) 53 µm; resin (AR) 44.5 µm, glass ionomer (AG) 29 µm. There was a significant difference among luting cements AG V/s AZ (p = 0.001) and AR V/s AG (p = 0.003), except AR V/s AZ (p = 0.213). All axial surfaces except mesial showed a significant difference. Conclusion The study concluded that different luting media have a definite effect over the final fit of AllCeram coping. Absolute marginal discrepancy was within the accepted level of 100 µm. Distal axial surface demonstrated a wider gap among all the luting agents
- MeSH
- Cementation methods MeSH
- Resin Cements MeSH
- Glass Ionomer Cements therapeutic use MeSH
- Zinc Phosphate Cement therapeutic use MeSH
- Dental Cements classification therapeutic use MeSH
- Dental Materials classification therapeutic use MeSH
- Publication type
- Evaluation Study MeSH
- Comparative Study MeSH
Hyaluronic acid (HA; synonyms- Hyaluronan, Hyaluronate) is a glycosaminoglycan found in the connective tissue of vertebrates. It is the most abundant glycosaminoglycan of higher molecular weight in the extracellular matrix of soft periodontal tissues. The use of HA in the treatment of inflammatory process is established in medical areas such as orthopedics, dermatology and ophthalmology. In the field of dentistry, it has shown anti-inflammatory and anti-bacterial effects in gingivitis and periodontitis therapy. Due to its tissue healing properties, it could be used as an adjunct to mechanical therapy in the treatment of periodontitis.
- MeSH
- Chemotherapy, Adjuvant methods utilization MeSH
- Extracellular Matrix physiology drug effects MeSH
- Financing, Organized MeSH
- Gingivitis drug therapy MeSH
- Hyaluronic Acid administration & dosage adverse effects therapeutic use MeSH
- Humans MeSH
- Periodontium physiology drug effects MeSH
- Periodontitis drug therapy MeSH
- Check Tag
- Humans MeSH
