- Publikační typ
- abstrakt z konference MeSH
The healthy development of the fetus depends on the exact course of pregnancy and delivery. Therefore, prenatal hypoxia remains between the greatest threats to the developing fetus. Our study aimed to assess the impact of prenatal hypoxia on postnatal development and behavior of the rats, whose mothers were exposed to hypoxia (10.5 % O2) during a critical period of brain development on GD20 for 12 h. This prenatal insult resulted in a delay of sensorimotor development of hypoxic pups compared to the control group. Hypoxic pups also had lowered postnatal weight which in males persisted up to adulthood. In adulthood, hypoxic males showed anxiety-like behavior in the OF, higher sucrose preference, and lower levels of grimace scale (reflecting the degree of negative emotions) in the immobilization chamber compared to the control group. Moreover, hypoxic animals showed hyperactivity in EPM and LD tests, and hypoxic females had reduced sociability compared to the control group. In conclusion, our results indicate a possible relationship between prenatal hypoxia and changes in sociability, activity, and impaired emotion regulation in ADHD, ASD, or anxiety disorders. The fact that changes in observed parameters are manifested mostly in males confirms that male sex is more sensitive to prenatal insults.
- MeSH
- acidobazická rovnováha MeSH
- bludiště - učení MeSH
- chování zvířat * MeSH
- gestační stáří MeSH
- hypoxie plodu komplikace patofyziologie MeSH
- modely nemocí na zvířatech MeSH
- pohybová aktivita MeSH
- potkani Wistar MeSH
- preference v jídle MeSH
- senzorimotorický kortex růst a vývoj MeSH
- sexuální faktory MeSH
- sociální interakce MeSH
- těhotenství MeSH
- úleková reakce MeSH
- věkové faktory MeSH
- zpožděný efekt prenatální expozice * MeSH
- zvířata MeSH
- Check Tag
- mužské pohlaví MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Congenital lung masses (CLM) the rare group of causes of acute respiratory insufficiency (RI) in newborns include congenital airway pulmonary malformation (CAPM), congenital overinflation, bronchopulmonary sequestration, and bronchial atresia. The presenting group consists of 13 newborns who were admitted to the Neonatal Department of Intensive Medicine (NDIM) during January 1st 2015-December 31st 2019 (8 males, 5 females, 2 premature/11 term newborns, spontaneous delivery: 2, caesarean section: 11) with positive prenatal diagnosis of CAPM in all cases. In 2 cases prenatal intervention was performed (drainage of the amniotic fluid, attempt of thoracentesis). Signs of acute RI immediately after delivery were seen in 5 newborns. Postnatal echocardiographic investigation confirmed the presence of increased pulmonary pressure in 8 patients, no patient had congenital heart abnormality. A thorax x-ray was positive also in asymptomatic patients. Computed tomography in patients brought detailed information about the position, size and character of CAPM. Six patients underwent surgery. In 15.4 % right lungs were affected by cystic malformation and in 23 % left lungs were affected. A final diagnosis of CAPM was confirmed in 5 patients using histopathologic examination. Multidisciplinary cooperation during prenatal as well as postnatal period is necessary.
- MeSH
- cystická adenomatoidní malformace plic vrozená komplikace diagnostické zobrazování patofyziologie chirurgie MeSH
- lidé MeSH
- novorozenec MeSH
- plíce abnormality diagnostické zobrazování patofyziologie chirurgie MeSH
- pneumektomie MeSH
- počítačová rentgenová tomografie MeSH
- respirační insuficience diagnostické zobrazování etiologie patofyziologie chirurgie MeSH
- retrospektivní studie MeSH
- rizikové faktory MeSH
- výsledek terapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- novorozenec MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- Publikační typ
- abstrakt z konference MeSH
This is an overview and assessment of the value of the International Interdisciplinary Toxicological Conferences TOXCON, which have been organized reciprocally in Slovakia and the Czech Republic since 1996. Characterization of the individual annual conferences and the results of mutual cooperation between the Slovak Toxicology Society (SETOX) and the Toxicological Section of the Czech Society for Experimental and Clinical Pharmacology and Toxicology of the Czech Medical Association of J. E. Purkyně (TS ČSEKFT ČLS JEP) are presented. Moreover, cooperation and common efforts to promote toxicology as a modern interdisciplinary subject with toxicological organizations from the Visegrad Group (V4) and within the Federation of European Societies of Toxicology EUROTOX are also highlighted.
- MeSH
- dějiny 20. století MeSH
- dějiny 21. století MeSH
- kongresy jako téma dějiny MeSH
- lidé MeSH
- toxikologie dějiny MeSH
- Check Tag
- dějiny 20. století MeSH
- dějiny 21. století MeSH
- lidé MeSH
- Publikační typ
- dopisy MeSH
- historické články MeSH
- Geografické názvy
- Česká republika MeSH
- Slovenská republika MeSH
- Publikační typ
- abstrakt z konference MeSH
- Publikační typ
- abstrakt z konference MeSH
