- Klíčová slova
- KISS syndrom, KIDD syndrom,
- MeSH
- atlantookcipitální kloub * zranění MeSH
- kojenec MeSH
- komplikace porodu * MeSH
- lidé MeSH
- management péče o pacienta metody MeSH
- novorozenec MeSH
- rizikové faktory MeSH
- techniky fyzikální terapie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- novorozenec MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- dítě MeSH
- dospělí MeSH
- fyzikální stimulace MeSH
- komplikace porodu MeSH
- lidé MeSH
- novorozenec MeSH
- paréza rehabilitace MeSH
- pohybová aktivita fyziologie MeSH
- poporodní paréza brachiálního plexu * etiologie klasifikace rehabilitace vrozené MeSH
- poranění nervového systému etiologie MeSH
- prognóza MeSH
- ramenní kloub patofyziologie MeSH
- reflexní terapie metody MeSH
- regenerace nervu fyziologie MeSH
- rozsah kloubních pohybů fyziologie MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé MeSH
- novorozenec MeSH
Our knowledge of tumor-infiltrating lymphocytes (TILs) is dramatically expanding. These cells have proven prognostic and therapeutic value for many cancer outcomes and potential to treat also disseminated breast, colorectal, or lung cancer. However, the therapeutical outcome of TILs is negatively affected by tumor mutational burden and neoantigens. On the other hand, it can be improved in combination with checkpoint blockade therapy. This knowledge and rapid detection techniques alongside gene editing allow us to classify and modify T cells in many ways. Hence, to tailor them precisely to the patient ́s needs as to program T cell receptors to recognize specific tumor-associated neoantigens and to insert them into lymphocytes or to select tumor neoantigen-specific T cells, for the development of vaccines that recognize tumor-specific antigens in tumors or metastases. Further studies and clinical trials in the field are needed for an even better-detailed understanding of TILs interactions and aiming in the fight against multiple cancers.
COVID-19, a significant global health threat, appears to be an immune-related disease. Failure of effective immune responses in initial stages of infection may contribute to development of cytokine storm and systemic inflammation with organ damage, leading to poor clinical outcomes. Disease severity and the emergence of new SARS-CoV-2 variants highlight the need for new preventative and therapeutic strategies to protect the immunocompromised population. Available data indicate that these people may benefit from adoptive transfer of allogeneic SARS-CoV-2-specific T cells isolated from convalescent individuals. This review first provides an insight into the mechanism of cytokine storm development, as it is directly related to the exhaustion of T cell population, essential for viral clearance and long-term antiviral immunity. Next, we describe virus-specific T lymphocytes as a promising and efficient approach for the treatment and prevention of severe COVID-19. Furthermore, other potential cell-based therapies, including natural killer cells, regulatory T cells and mesenchymal stem cells are mentioned. Additionally, we discuss fast and effective ways of producing clinical-grade antigen-specific T cells which can be cryopreserved and serve as an effective "off-the-shelf" approach for rapid treatment of SARS-CoV-2 infection in case of sudden patient deterioration.
- MeSH
- COVID-19 * terapie MeSH
- cytokiny MeSH
- lidé MeSH
- SARS-CoV-2 * MeSH
- syndrom uvolnění cytokinů terapie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
- MeSH
- lidé MeSH
- ortopedické fixační pomůcky MeSH
- osteonekróza etiologie MeSH
- plošný screening metody MeSH
- reflexní terapie metody MeSH
- techniky fyzikální terapie MeSH
- ultrasonografie metody MeSH
- vývojová kyčelní dysplazie * patologie prevence a kontrola rehabilitace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Pancreatic carcinoma is usually diagnosed late when treatment options are limited and is considered a chemo-resistant malignancy. However, early stage, good performance status and specific patient subgroup are thought to have a more favorable prognosis. Search for novel molecular biomarkers, which could predict treatment resistance, represents a major opportunity, but also a challenge in further research. This review summarizes most aspects of individualized therapy of pancreatic cancer including promising biomarkers, BRCA-deficient pancreatic cancer and its etiology. It may be estimated that nearly a third of metastatic pancreatic ductal adenocarcinoma patients could benefit from treatment other than gold standard chemotherapy. Thus, other aspects of an individualized approach concerning the main factors for the choice of the best therapy for individual pancreatic cancer patient (surgery and chemotherapy), as well as the future directions (target therapy and immunotherapy), are also addressed.
- MeSH
- adenokarcinom farmakoterapie genetika imunologie patologie MeSH
- chemorezistence genetika imunologie MeSH
- cílená molekulární terapie MeSH
- imunoterapie MeSH
- individualizovaná medicína * MeSH
- lidé MeSH
- nádorové biomarkery genetika MeSH
- nádory slinivky břišní farmakoterapie genetika imunologie patologie MeSH
- protokoly protinádorové kombinované chemoterapie škodlivé účinky terapeutické užití MeSH
- signální transdukce účinky léků MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
