- MeSH
- Affective Symptoms etiology pathology MeSH
- Automatism etiology MeSH
- Epileptic Syndromes pathology MeSH
- Cognition Disorders etiology MeSH
- Humans MeSH
- Motor Disorders etiology MeSH
- Autonomic Nervous System Diseases etiology pathology MeSH
- Consciousness Disorders etiology pathology MeSH
- Signs and Symptoms * MeSH
- Seizures * classification pathology MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
We tested the relation between a single short tonic-clonic seizure elicited by flurothyl vapors and changes of learning in Morris water maze (MWM) in Wistar rats. Oxidative stress usually accompanies seizures. Large melatonin doses were applied immediately before and after seizures to test consequences on learning impairment. One hour of hypobaric hypoxia (8000 m) three days prior to the seizure served as an activator of intrinsic antioxidant systems. Learning in MWM (7 days) started 24 h after seizures. Following seizures, latencies in MWM were longer than in controls and were shortened by hypoxia and preventive melatonin application. Melatonin was also applied before hypoxia to influence free radical (FR) production and intrinsic antioxidant activation. Some behavioral characteristics were changed and preconditioning effect of hypoxia was reduced. Melatonin after seizure (150 s and 6 h) had negligible effect. Results allow us to hypothesize about the role of FR and the beneficial effect of melatonin on the behavioral consequences of seizures.
- MeSH
- Analysis of Variance MeSH
- Antioxidants therapeutic use MeSH
- Automatism etiology prevention & control MeSH
- Maze Learning drug effects MeSH
- Time Factors MeSH
- Flurothyl toxicity MeSH
- Blood-Brain Barrier drug effects physiopathology MeSH
- Hypoxia complications MeSH
- Convulsants toxicity MeSH
- Rats MeSH
- Melatonin therapeutic use MeSH
- Disease Models, Animal MeSH
- Learning Disabilities etiology prevention & control MeSH
- Reaction Time drug effects MeSH
- Seizures chemically induced complications pathology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
We analyzed peri-ictal bed leaving (PBL) symptoms in 105 patients with temporal lobe epilepsy (TLE). All patients were classified as Engel I at the 2-year follow-up visit. Histopathological examination revealed hippocampal sclerosis (TLE-HS) in 64 patients and other lesions in 38 patients (TLE-other); 3 patients had no lesions. We reviewed 412 seizures. PBL was defined as lateralized leaving of the bed occurring during the seizure or up to 3 minutes after the end of the seizure. PBL was observed in 28 of 105 patients (26.7%), and in 45 of 412 seizures (10.9%). PBL occurred more frequently in patients with TLE-HS than in patients with TLE-other (32.8% vs 17.1%, P=0.058). PBL was ipsilateral to the seizure onset in 71.4% of patients and 71.2% of seizures (P=0.012 and P<0.001). In patients with TLE-HS, PBL was ipsilateral to seizure onset in 76.2% of patients and 81.2% of seizures (P=0.008 and P<0.001). In patients with TLE-other, PBL was ipsilateral to seizure onset in 42.8% of patients and 46.1% of seizures. There were no differences in the incidence and lateralizing value between patients with right-sided and those with left-sided TLE. PBL is a relatively frequent peri-ictal sign in patients with TLE. The side of PBL in patients with TLE-HS lateralizes the seizure onset to the ipsilateral temporal lobe.
- MeSH
- Video Recording MeSH
- Automatism epidemiology etiology MeSH
- Time Factors MeSH
- Adult MeSH
- Epilepsy, Temporal Lobe epidemiology physiopathology MeSH
- Functional Laterality physiology MeSH
- Incidence MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Adolescent MeSH
- Young Adult MeSH
- Retrospective Studies MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
We retrospectively investigated rare peri-ictal vegetative symptoms (PIVS) in 380 seizures of 97 patients with temporal lobe epilepsy (TLE): 234 seizures of 60 patients with TLE with mesiotemporal sclerosis (TLE/MTS) and 146 seizures of 37 patients with TLE with other lesions (TLE/non-MTS) who were at least 2 years after epilepsy surgery and classified as Engel I. We assessed the following PIVS: peri-ictal cough (pC), peri-ictal water drinking (pWD), peri-ictal vomiting (pV), and peri-ictal spitting (pS). We observed pC in 24.7% of patients and 10% of seizures; pWD in 14.4% of patients and 5.9% of seizures; pV and pS occurred more rarely. Both pWD and pC occurred significantly more often in those with TLE of the non- language-dominant hemisphere. The limited occurrence of pV and pS made it impossible to perform statistical analysis for these symptoms. In patients with TLE, pC and pWD were quite frequent; we observed pV and pS less frequently. Both pC and pWD have a significant lateralizing value in TLE.
- MeSH
- Automatism etiology MeSH
- Adult MeSH
- Epilepsy, Temporal Lobe complications MeSH
- Functional Laterality physiology MeSH
- Cough etiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Longitudinal Studies MeSH
- Adolescent MeSH
- Young Adult MeSH
- Drinking physiology MeSH
- Retrospective Studies MeSH
- Seizures complications MeSH
- Vomiting etiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- MeSH
- Automatism etiology therapy MeSH
- Epilepsy, Partial, Motor etiology complications physiopathology MeSH
- Humans MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Automatism MeSH
- Research Support as Topic MeSH
- Humans MeSH
- Attention MeSH
- Psychological Theory MeSH
- Consciousness MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- Comparative Study MeSH
- MeSH
- Anticonvulsants administration & dosage pharmacology MeSH
- Automatism prevention & control MeSH
- Epilepsy, Temporal Lobe prevention & control MeSH
- Epilepsy prevention & control MeSH
- Rats MeSH
- Kainic Acid administration & dosage MeSH
- Disease Models, Animal MeSH
- Seizures chemically induced prevention & control MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- MeSH
- Serotonin Antagonists administration & dosage metabolism MeSH
- Automatism MeSH
- Clonidine antagonists & inhibitors administration & dosage metabolism MeSH
- Rats growth & development MeSH
- Kainic Acid administration & dosage metabolism MeSH
- Animals MeSH
- Check Tag
- Rats growth & development MeSH
- Animals MeSH
