Aim: This study aims to assess the effectiveness of ATHP-HC on the severity of nausea and vomiting, relaxation state, brainwaves, and quality of life in women with Nausea and Vomiting in Pregnancy (NVP). Methods: A quasi-experimental study was conducted on 62 pregnant women randomly allocated into intervention and control groups using a pre-post-test. Researchers provided ATHP-HC to the intervention group and Cirebon Gamelan audio therapy to the control group. The research instruments included PUQE-24-hour scoring, measurement of vital signs, brainwaves using NeuroSky MindWave Mobile II, and WHOQOL-BREF. The data collected were processed with SPSS version 24.0 and analyzed using the statistical formula paired t-test. Results: The results of the study showed that there were significant differences between nausea and vomiting scores (p = 0.000), relaxation levels (p = 0.003 in the intervention group and p = 0.000 in the control group), and quality of life (p = 0.000), before and after the treatment in the intervention group and the control group. There was a significant difference in the state of relaxation after the intervention in the two groups of respondents (p = 0.001). There was no significant difference in the proportion of increased meditation in the two groups of respondents (p = 0.707). Conclusion: As relaxation and meditation music, ATHP-HC can be a complementary therapy for pregnant women to overcome NVP.
- MeSH
- kvalita života MeSH
- lidé MeSH
- mozkové vlny MeSH
- muzikoterapie * metody MeSH
- nauzea terapie MeSH
- nervový systém - fyziologické jevy MeSH
- průzkumy a dotazníky MeSH
- relaxace MeSH
- statistika jako téma MeSH
- těhotenství * MeSH
- zvracení terapie MeSH
- Check Tag
- lidé MeSH
- těhotenství * MeSH
- ženské pohlaví MeSH
- Publikační typ
- klinická studie MeSH
Pooperační nevolnost a zvracení (PONV) je častou pooperační komplikací, která postihuje 20-30 % dětí, u vysoce rizikových výkonů stoupá incidence až k 80 %. PONV vedle subjektivního dyskomfortu zvyšuje pooperační morbiditu a ohrožuje dítě dehydratací, dehiscencí operační rány a následným krvácením. Dochází k prodloužení pobytu na dospávacím pokoji a celkové doby hospitalizace. Management PONV spočívá v identifikaci rizikových pacientů a zahájení adekvátní prevence. Lékem volby je dexametazon nebo ondansetron, u vysoce rizikových dětí jejich kombinace. V případě selhání prevence je indikace k podání antiemetika z jiné farmakologické skupiny.
Postoperative nausea and vomiting (PONV) is a common postoperative complication with overall incidence of 20-30 %, however, with high risk procedures it increases up to 80 %. PONV is the main cause of the patient ́s discomfort, worsens perioperative morbidity and put the child at risk of dehydratation, dehiscence of surgical wound and bleeding. PONV prolongs the lenght of stay (PACU, in-hospital care). The cornerstone of PONV management is the identification of high risk pediatric patients and an adequate pre-operative pharmacological prevention. Dexamethasone and ondansetron (or their combination) are the first line medications. In case of failure, rescue therapy should be provided with other pharmacological agents.
- MeSH
- antiemetika MeSH
- dexamethason aplikace a dávkování terapeutické užití MeSH
- dítě MeSH
- lidé MeSH
- ondansetron aplikace a dávkování terapeutické užití MeSH
- pooperační nevolnost a zvracení * diagnóza farmakoterapie prevence a kontrola MeSH
- rizikové faktory MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- přehledy MeSH
- MeSH
- aspirace do dýchacích cest * etiologie komplikace terapie MeSH
- endoskopie metody MeSH
- gastroenteritida MeSH
- kojenec * MeSH
- lidé MeSH
- ořechy škodlivé účinky MeSH
- rentgendiagnostika hrudníku metody MeSH
- výsledek terapie MeSH
- zvracení etiologie MeSH
- Check Tag
- kojenec * MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Cíl: V této studii jsme se zaměřili na zjištění role parametrů periferní krve a indexu systémového zánětu (SII – systemic inflammatory index) v diagnostice hyperemesis gravidarum (HG) a zda mají prediktivní hodnotu při určování délky hospitalizace a rizika rehospitalizaci v případech HG. Materiál a metoda: V retrospektivní studii byly těhotné ženy hospitalizované pro HG (n = 112) a těhotné ženy zcela zdravé (n = 112) přiřazeny ke gestačnímu věku. Byly hodnoceny parametry zánětu periferní krve celé studované skupiny. Byla zaznamenávána délka hospitalizace a počet rehospitalizací pro případy HG. Výsledky: Do studie bylo zařazeno celkem 224 pacientů, 112 (50 %) v kontrolní skupině a 112 (50 %) ve skupině HG. Byla prokázána pozitivní korelace mezi zvýšenou ketonurií a délkou hospitalizace, parametry periferní krve a SII. Stupeň ketonurie byl shledán jako statisticky nevýznamný pro stanovení rizika rehospitalizace (p = 0,927). Do nemocnice byl přijato zpět 28,57 % (n = 32) případů HG. Při zohlednění délky hospitalizace bylo zjištěno, že SII je statisticky významný u hospitalizací trvajících déle než 2 dny (p = 0,001), ale nikoli u rehospitalizací (p = 0,3). Závěr: SII je významný v diagnostice a určování hospitalizace HG. Je dostačující pro stanovení délky hospitalizace, nikoli však rizika rehospitalizace, která je ukazatelem závažnosti onemocnění.
Objective: In this study, we aimed to investigate the role of peripheral blood parameters and the systemic inflammatory index (SII) in the diagnosis of hyperemesis gravidarum (HG) and whether they have a predictive value in determining the length of hospital stay and the risk of rehospitalization in HG cases. Materials and methods: In the retrospective study, pregnant women who were hospitalized due to HG (n = 112) and pregnant women who were completely healthy (n = 112) were matched for gestational age. Peripheral blood inflammation parameters of the entire study group were evaluated. The length of hospital stay and rehospitalization rate for HG cases were recorded. A total of 224 patients, 112 (50%) in the control group and 112 (50%) in the HG group were included in the study. There was a positive correlation between increased ketonuria and length of hospitalization, peripheric blood parameters, and SII. The degree of ketonuria was found to be statistically insignificant in determining the risk of rehospitalization (p = 0.927). About 28.57% (n = 32) of all HG cases were readmitted to the hospital. When the length of hospital stay was considered, SII was found to be statistically significant in hospitalizations lasting more than 2 days (p = 0.001), but not in rehospitalizations (p = 0.3). Conclusion: SII is significant in diagnosing and determining hospitalization of HG. It is sufficient to determine the length of hospital stay but not rehospitalization risk, which is an indicator of disease severity.
The type B trichothecenes pollute food crops and have been associated to alimentary toxicosis resulted in emetic reaction in human and animal. This group of mycotoxins consists deoxynivalenol (DON) and four structurally related congeners: 3-acetyl-deoxynivalenol (3-ADON), 15-acetyl deoxynivalenol (15-ADON), nivalenol (NIV) and 4-acetyl-nivalenol (fusarenon X, FX). While emesis induced by intraperitoneally dosed to DON in the mink has been related to plasma up-grading of 5-hydroxytryptamine (5-HT) and neurotransmitters peptide YY (PYY), the impact of oral dosing with DON or its four congeners on secretion of these chemical substances have not been established. The aim of this work was to contraste emetic influence to type B trichothecene mycotoxins by orally dosing and involve these influence to PYY and 5-HT. All five toxins attracted marked emetic reaction that are relevant to elevated PYY and 5-HT. The reduction in vomiting induced by the five toxins and PYY was due to blocking of the neuropeptide Y2 receptor. The inhibition of the induced vomiting response by 5-HT and all five toxins is regulated by the 5-HT3 receptor inhibitor granisetron. In a word, our results indicate that PYY and 5-HT take a key role in the emetic reaction evoked by type B trichothecenes.
- MeSH
- emetika škodlivé účinky MeSH
- lidé MeSH
- mykotoxiny * škodlivé účinky MeSH
- norek MeSH
- peptid YY MeSH
- serotonin MeSH
- trichotheceny typu B * škodlivé účinky MeSH
- trichotheceny * toxicita MeSH
- zvířata MeSH
- zvracení chemicky indukované MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Postdischarge nausea and vomiting (PDNV) cause substantial pediatric morbidity with potentially serious postoperative complications. However, few studies have addressed PDNV prevention and treatment in pediatric patients. Here we searched the literature and processed it in a narrative review describing PDNV incidence, risk factors, and management in pediatric patients.. A successful strategy for reducing PDNV considers both the pharmacokinetics of the antiemetic agents and the principle of multimodal prophylaxis, utilizing agents of different pharmacologic classes. Since many highly effective antiemetic agents have relatively short half-lives, a different approach must be used to prevent PDNV. A combination of oral and intravenous medications with longer half-lives, such as palonosetron or aprepitant, can be used. In addition, we designed a prospective observational study with the primary objective of determining PDNV incidence. In our study group of 205 children, the overall PDNV incidence was 14.6% (30 of 205), including 21 children suffering from nausea and 9 suffering from vomiting.
- MeSH
- antiemetika * terapeutické užití MeSH
- dítě MeSH
- lidé MeSH
- následná péče MeSH
- pooperační nevolnost a zvracení prevence a kontrola farmakoterapie MeSH
- pozorovací studie jako téma MeSH
- propuštění pacienta MeSH
- prospektivní studie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Elevated levels of nausea and vomiting in pregnancy (NVP) and disgust sensitivity have been observed in the first trimester and both are thought to have a protective function for the mother and her fetus. Their aetiology is not clear, however, with previous studies attributing elevated NVP and disgust to various factors including endocrine changes, immunological changes, and psychological variables. To date, no study has directly assessed the relationship between disgust and NVP. Here, we prospectively collected two independent samples (S1 and S2; n1 = 201, n2 = 391) of women in the first trimester of pregnancy, who completed the Index of Nausea, Vomiting, and Retching and the Disgust Scale-Revised. We also measured free β-human chorionic gonadotropin (hCG) and pregnancy-associated plasma protein A (PAPP-A) in maternal serum. Our results did not confirm any association between NVP and disgust; in addition, they indicate that NVP and disgust may have different proximate causes. Disgust sensitivity was significantly negatively correlated with free β-hCG and (only in S1) with PAPP-A. In contrast, NVP was significantly positively associated with free β-hCG levels and (only in S1) with PAPP-A. While low hCG levels seem to be an important indicator for activation of the behavioral immune system in the first trimester, increased hCG levels play a role in stronger symptoms of NVP, a result consistent with previous studies. Levels of PAPP-A are likely part of a larger network of immunological and endocrine responses and do not appear to provide sufficient information for predicting women's NVP and disgust sensitivity.
- MeSH
- biologické markery MeSH
- komplikace těhotenství * MeSH
- lidé MeSH
- lidský choriogonadotropin, beta podjednotka MeSH
- nauzea etiologie MeSH
- odpor * MeSH
- první trimestr těhotenství MeSH
- těhotenský plazmatický protein A metabolismus MeSH
- těhotenství MeSH
- zvracení etiologie MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: A recent study focusing on dietary predictors of nausea and vomiting in pregnancy (NVP) found that women with higher levels of partner support, and those who had used oral contraception (OC) when they met the father, both tended to report less severe NVP compared with previous non-users or those with less supportive partners. We provide a further test of these factors, using a large sample of women from four countries who retrospectively scored their NVP experience during their first pregnancy. METHODS: We recruited women who had at least one child to participate in a retrospective online survey. In total 2321 women completed our questionnaire including items on demographics, hormonal contraception, NVP, and partner support. We used general linear models and path analysis to analyse our data. RESULTS: Women who had used OC when they met the father of their first child tended to report lower levels of NVP, but the effect size was small and did not survive adding the participant's country to the model. There was no relationship between NVP and partner support in couples who were still together, but there was a significant effect among those couples that had since separated: women whose ex-partner had been relatively supportive reported less severe NVP. Additional analyses showed that women who were older during their first pregnancy reported less severe NVP, and there were also robust differences between countries. CONCLUSIONS: These results provide further evidence for multiple influences on women's experience of NVP symptoms, including levels of perceived partner support.
- MeSH
- antikoncepce metody psychologie MeSH
- antikoncepční chování psychologie MeSH
- charakteristiky rodiny MeSH
- dítě MeSH
- internet MeSH
- komplikace těhotenství * etiologie prevence a kontrola psychologie MeSH
- kontraceptiva orální * aplikace a dávkování terapeutické užití MeSH
- lidé MeSH
- nauzea * etiologie prevence a kontrola psychologie MeSH
- retrospektivní studie MeSH
- sexuální partneři * psychologie MeSH
- sociální opora * psychologie MeSH
- těhotenství MeSH
- zdravotnické přehledy MeSH
- zvracení * etiologie prevence a kontrola psychologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- srovnávací studie MeSH
- MeSH
- bolest etiologie MeSH
- Burkittův lymfom diagnóza komplikace MeSH
- diferenciální diagnóza MeSH
- fatální výsledek MeSH
- hematemeze * etiologie terapie MeSH
- hydrolasy analýza MeSH
- inhibitory protonové pumpy terapeutické užití MeSH
- lidé MeSH
- metastázy nádorů diagnostické zobrazování MeSH
- mladiství MeSH
- nádory trávicího systému * diagnostické zobrazování patologie MeSH
- progrese nemoci MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
