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MeSH: Endoscopy, Digestive System-statistics & numerical data

5 záznamů v Medvik Filtry

Článek online

The influence of microscopic inflammation at resection margins on early postoperative endoscopic recurrence after ileocaecal resection for Crohn's disease

Poredská, Karolina
Autor Autorita Department of Gastroenterology and Internal Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno
Kunovský, Lumír
Autor Autorita Department of Gastroenterology and Internal Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno
Marek, Filip
Autor Autorita ORCID Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno
Kala, Zdeněk, 1960-
Autor Autorita Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno
Procházka, Vladimír, 1972-
Autor Autorita Department of Surgery, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno
Dolina, Jiří
Autor Autorita Department of Gastroenterology and Internal Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno
Zbořil, Vladimír, 1955-
Autor Autorita Department of Gastroenterology and Internal Medicine, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno
Kovalčíková, Petra
Autor Autorita Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno
Pavlík, Tomáš
Autor Autorita Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Brno
Jabandžiev, Petr
Autor Autorita Department of Pediatrics, University Hospital Brno, Faculty of Medicine, Masaryk University, Brno

Gastroenterologie a hepatologie. 2021 ; 75 (1) : 29-37.

ISSN 1804-7874
Medvik
Zdroj

Background and Aims: The pathogenesis and risk factors for early postoperative endoscopic recurrence of Crohn's disease (CD) remain unclear. Thus, this study aimed to identify whether histological inflammation at the resection margins after an ileocaecal resection influences endoscopic recurrence. Methods: We have prospectively followed up patients with CD who underwent ileocaecal resection at our hospital between January 2012 and January 2018. The specimens were histologically analysed for inflammation at both of the resection margins (ileal and colonic). We evaluated whether histological results of the resection margins are correlated with endoscopic recurrence of CD based on colonoscopy 6 months after ileocaecal resection. Second, we assessed the influence of known risk factors and preoperative therapy on endoscopic recurrence of CD. Results: A total of 107 patients were included in our study. Six months after ileocaecal resection, 23 patients (21.5%) had an endoscopic recurrence of CD. The histological signs of CD at the resection margins were associated with a higher endoscopic recurrence (56.5% versus 4.8%, p < 0.001). Disease duration from diagnosis to surgery (p = 0.006) and the length of the resected bowel (p = 0.019) were significantly longer in patients with endoscopic recurrence. Smoking was also proved to be a risk factor for endoscopic recurrence (p = 0.028). Conclusions: Histological inflammation at the resection margins was significantly associated with a higher risk of early postoperative endoscopic recurrence after an ileocaecal resection for CD.

Článek

The Influence of Microscopic Inflammation at Resection Margins on Early Postoperative Endoscopic Recurrence After Ileocaecal Resection for Crohn's Disease

Journal of Crohn's and colitis. 2020 ; 14 (3) : 361-368. [pub] 2020Mar13

J Crohns Colitis
ISSN 1876-4479
Medvik
Zdroj

BACKGROUND AND AIMS: The pathogenesis and risk factors for early postoperative endoscopic recurrence of Crohn's disease [CD] remain unclear. Thus, this study aimed to identify whether histological inflammation at the resection margins after an ileocaecal resection influences endoscopic recurrence. METHODS: We have prospectively followed up patients with CD who underwent ileocaecal resection at our hospital between January 2012 and January 2018. The specimens were histologically analysed for inflammation at both of the resection margins [ileal and colonic]. We evaluated whether histological results of the resection margins are correlated with endoscopic recurrence of CD based on colonoscopy 6 months after ileocaecal resection. Second, we assessed the influence of known risk factors and preoperative therapy on endoscopic recurrence of CD. RESULTS: A total of 107 patients were included in our study. Six months after ileocaecal resection, 23 patients [21.5%] had an endoscopic recurrence of CD. The histological signs of CD at the resection margins were associated with a higher endoscopic recurrence [56.5% versus 4.8%, p < 0.001]. Disease duration from diagnosis to surgery [p = 0.006] and the length of the resected bowel [p = 0.019] were significantly longer in patients with endoscopic recurrence. Smoking was also proved to be a risk factor for endoscopic recurrence [p = 0.028]. CONCLUSIONS: Histological inflammation at the resection margins was significantly associated with a higher risk of early postoperative endoscopic recurrence after an ileocaecal resection for CD.