Renální insuficience je významným faktorem ovlivňujícím schopnost organismu udržovat vnitřní prostředí. V klinicky definovaných případech je u pacientů nutná náhrada eliminační funkce ledvin. Technické metody umožňují eliminaci toxických metabolitů, dochází ovšem také k eliminaci některých léčiv. Z tohoto pohledu je významné posouzení rizika kumulace léčiv u renální insuficience, stejně tak jako vlivu eliminační metody na clearance látek a přizpůsobení dávky, případně intervalu dávkování. Pro odhad eliminace léčiva je nezbytné zohlednit jak vlastnosti použité eliminační metody, tak farmakokinetické parametry léčiva.
Renal insufficiency is a significant factor affecting body's ability to maintain the internal homeostasis. In clinically defined cases, renal replacement therapy is required. Technical methods allow not only the elimination of toxic metabolites but also the elimination of certain drugs. According to this, it is crucial to determine the drug cummulation risk. In addition, quantitative drug clearance provided by the elimination method is as much relevant in order to provide dose and interval adjustment. To estimate drug elimination, both properties of the elimination methods and pharmacokinetic parameters of the drug should be taken into account.
- MeSH
- Renal Dialysis * methods trends utilization MeSH
- Renal Elimination * physiology drug effects MeSH
- Pharmacokinetics MeSH
- Hemodiafiltration methods trends utilization MeSH
- Hemofiltration methods trends utilization MeSH
- Pharmaceutical Preparations metabolism MeSH
- Humans MeSH
- Interdisciplinary Communication MeSH
- Renal Replacement Therapy * methods instrumentation utilization MeSH
- Peritoneal Dialysis methods trends utilization MeSH
- Renal Insufficiency diagnosis complications therapy MeSH
- Statistics as Topic MeSH
- Kidney Transplantation methods trends utilization MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
- Keywords
- vysokoobjemová hemodiafiltrace,
- MeSH
- Patient Safety MeSH
- Hemodiafiltration * methods utilization MeSH
- Humans MeSH
- Renal Insufficiency therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
- MeSH
- Biological Therapy methods trends utilization MeSH
- Diabetic Nephropathies drug therapy therapy MeSH
- Drug Therapy methods trends MeSH
- Hemodiafiltration methods utilization MeSH
- Congresses as Topic MeSH
- Humans MeSH
- Kidney Diseases drug therapy surgery therapy MeSH
- Prognosis MeSH
- Societies, Medical organization & administration MeSH
- Kidney Transplantation methods trends MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
- Interview MeSH
