Renální insuficience je významným faktorem ovlivňujícím schopnost organismu udržovat vnitřní prostředí. V klinicky definovaných případech je u pacientů nutná náhrada eliminační funkce ledvin. Technické metody umožňují eliminaci toxických metabolitů, dochází ovšem také k eliminaci některých léčiv. Z tohoto pohledu je významné posouzení rizika kumulace léčiv u renální insuficience, stejně tak jako vlivu eliminační metody na clearance látek a přizpůsobení dávky, případně intervalu dávkování. Pro odhad eliminace léčiva je nezbytné zohlednit jak vlastnosti použité eliminační metody, tak farmakokinetické parametry léčiva.

Renal insufficiency is a significant factor affecting body's ability to maintain the internal homeostasis. In clinically defined cases, renal replacement therapy is required. Technical methods allow not only the elimination of toxic metabolites but also the elimination of certain drugs. According to this, it is crucial to determine the drug cummulation risk. In addition, quantitative drug clearance provided by the elimination method is as much relevant in order to provide dose and interval adjustment. To estimate drug elimination, both properties of the elimination methods and pharmacokinetic parameters of the drug should be taken into account.

• MeSH
• Renal Dialysis * methods   trends   utilization   MeSH
• Renal Elimination * physiology   drug effects   MeSH
• Pharmacokinetics MeSH
• Hemodiafiltration methods   trends   utilization   MeSH
• Hemofiltration methods   trends   utilization   MeSH
• Pharmaceutical Preparations metabolism   MeSH
• Humans MeSH
• Interdisciplinary Communication MeSH
• Renal Replacement Therapy * methods   instrumentation   utilization   MeSH
• Peritoneal Dialysis methods   trends   utilization   MeSH
• Renal Insufficiency diagnosis   complications   therapy   MeSH
• Statistics as Topic MeSH
• Kidney Transplantation methods   trends   utilization   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Review MeSH

• Keywords
• cílená biologická terapie,
• MeSH
• Autoimmune Diseases therapy   MeSH
• Biological Therapy history   methods   trends   MeSH
• Kidney Failure, Chronic * prevention & control   therapy   MeSH
• Cyclophosphamide therapeutic use   MeSH
• Cytokines antagonists & inhibitors   MeSH
• Renal Dialysis history   methods   trends   MeSH
• Genetic Research * MeSH
• Glomerulonephritis etiology   prevention & control   therapy   MeSH
• Adrenal Cortex Hormones therapeutic use   MeSH
• Humans MeSH
• Melanoma immunology   therapy   MeSH
• Lung Neoplasms immunology   therapy   MeSH
• Renal Replacement Therapy methods   trends   utilization   MeSH
• Receptor Protein-Tyrosine Kinases antagonists & inhibitors   therapeutic use   MeSH
• Vasculitis etiology   prevention & control   therapy   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Interview MeSH

• MeSH
• Renal Insufficiency, Chronic * diagnosis   classification   prevention & control   MeSH
• Kidney Failure, Chronic * diagnosis   classification   prevention & control   MeSH
• Diagnostic Techniques, Urological utilization   MeSH
• Child MeSH
• Drug Therapy methods   utilization   MeSH
• Glomerulonephritis etiology   physiopathology   therapy   MeSH
• Glomerular Filtration Rate MeSH
• Hypertension etiology   therapy   MeSH
• Disease Attributes MeSH
• Creatinine isolation & purification   blood   MeSH
• Humans MeSH
• Adolescent MeSH
• Renal Replacement Therapy * methods   standards   utilization   MeSH
• Polycystic Kidney, Autosomal Recessive physiopathology   therapy   MeSH
• Growth Disorders MeSH
• Proteinuria diagnosis   prevention & control   therapy   MeSH
• Risk Factors MeSH
• Statistics as Topic MeSH
• Congenital Abnormalities epidemiology   etiology   MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH

• MeSH
• Kidney Failure, Chronic * diagnosis   prevention & control   therapy   MeSH
• Diabetes Mellitus prevention & control   MeSH
• Renal Dialysis methods   trends   utilization   MeSH
• Hemodialysis, Home methods   trends   utilization   MeSH
• Glomerular Filtration Rate MeSH
• Informed Consent psychology   legislation & jurisprudence   MeSH
• Conservative Treatment * methods   trends   utilization   MeSH
• Humans MeSH
• Meta-Analysis as Topic MeSH
• Neoplasms complications   prevention & control   MeSH
• Renal Replacement Therapy * classification   methods   utilization   MeSH
• Obesity complications   prevention & control   MeSH
• Peritoneal Dialysis methods   trends   utilization   MeSH
• Risk Factors MeSH
• Waiting Lists MeSH
• Practice Guidelines as Topic MeSH
• Statistics as Topic MeSH
• Kidney Transplantation methods   trends   utilization   MeSH
• Age Factors MeSH
• Check Tag
• Humans MeSH

• MeSH
• Arteriovenous Fistula surgery   nursing   MeSH
• Arteriovenous Shunt, Surgical utilization   MeSH
• Central Venous Catheters adverse effects   trends   utilization   MeSH
• Vascular Access Devices * trends   utilization   MeSH
• Blood Vessel Prosthesis adverse effects   trends   utilization   MeSH
• Renal Insufficiency, Chronic * diagnosis   etiology   therapy   MeSH
• Renal Dialysis methods   trends   utilization   MeSH
• Catheter-Related Infections etiology   complications   MeSH
• Humans MeSH
• Interdisciplinary Communication MeSH
• Renal Replacement Therapy * methods   trends   utilization   MeSH
• Practice Guidelines as Topic MeSH
• Statistics as Topic MeSH
• Ultrasonography methods   utilization   MeSH
• Venous Thrombosis etiology   complications   therapy   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Early Medical Intervention methods   trends   utilization   MeSH
• Time Factors MeSH
• Renal Insufficiency, Chronic * diagnosis   classification   prevention & control   MeSH
• Renal Dialysis methods   trends   utilization   MeSH
• Humans MeSH
• Meta-Analysis as Topic MeSH
• Renal Replacement Therapy * methods   trends   utilization   MeSH
• Waiting Lists MeSH
• Practice Guidelines as Topic standards   MeSH
• Statistics as Topic MeSH
• Kidney Transplantation * methods   trends   utilization   MeSH
• Outcome and Process Assessment, Health Care methods   utilization   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Renal Insufficiency, Chronic * diagnosis   classification   prevention & control   MeSH
• Tissue Donors psychology   education   legislation & jurisprudence   MeSH
• Transplantation, Homologous methods   trends   utilization   MeSH
• Hypertension MeSH
• Humans MeSH
• Renal Replacement Therapy methods   trends   utilization   MeSH
• Blood Group Incompatibility prevention & control   MeSH
• Obesity complications   MeSH
• Risk Factors MeSH
• Practice Guidelines as Topic MeSH
• Statistics as Topic MeSH
• Kidney Transplantation * methods   trends   utilization   MeSH
• Age Factors MeSH
• Donor Selection methods   trends   utilization   MeSH
• Legislation, Medical standards   utilization   MeSH
• Living Donors * psychology   education   legislation & jurisprudence   MeSH
• Check Tag
• Humans MeSH

• MeSH
• Anemia diagnosis   MeSH
• Early Medical Intervention * methods   trends   utilization   MeSH
• Renal Insufficiency, Chronic * diagnosis   classification   prevention & control   MeSH
• Diabetes Mellitus diagnosis   prevention & control   MeSH
• Renal Dialysis * methods   trends   utilization   MeSH
• Glomerular Filtration Rate MeSH
• Hypertension diagnosis   prevention & control   MeSH
• Conservative Treatment methods   utilization   MeSH
• Creatinine isolation & purification   blood   MeSH
• Humans MeSH
• Evidence-Based Medicine trends   MeSH
• Meta-Analysis as Topic MeSH
• Renal Replacement Therapy methods   trends   utilization   MeSH
• Proteinuria urine   MeSH
• Risk Factors MeSH
• Practice Guidelines as Topic MeSH
• Statistics as Topic MeSH
• Kidney Function Tests methods   utilization   MeSH
• Check Tag
• Humans MeSH
• Geographicals
• Czech Republic MeSH
• Europe MeSH
• United States MeSH

• MeSH
• Early Medical Intervention MeSH
• Renal Insufficiency, Chronic * classification   prevention & control   therapy   MeSH
• Renal Dialysis methods   trends   utilization   MeSH
• Phosphorus isolation & purification   blood   MeSH
• Comorbidity MeSH
• Comprehensive Health Care methods   trends   utilization   MeSH
• Humans MeSH
• Meta-Analysis as Topic MeSH
• Interdisciplinary Communication * MeSH
• Renal Replacement Therapy methods   trends   utilization   MeSH
• Nephrology methods   organization & administration   trends   MeSH
• Hospitals, Special * organization & administration   trends   utilization   MeSH
• Parathyroid Hormone isolation & purification   blood   adverse effects   MeSH
• Prognosis MeSH
• Proteinuria complications   urine   prevention & control   MeSH
• Risk Factors MeSH
• Statistics as Topic MeSH
• Kidney Transplantation methods   trends   utilization   MeSH
• Age Factors MeSH
• Check Tag
• Humans MeSH

• MeSH
• Albuminuria diagnosis   etiology   physiopathology   MeSH
• Antihypertensive Agents administration & dosage   adverse effects   therapeutic use   MeSH
• Arteriosclerosis diagnosis   etiology   physiopathology   MeSH
• Biomedical Research methods   trends   MeSH
• Renal Insufficiency, Chronic * diagnosis   epidemiology   prevention & control   MeSH
• Fibrosis MeSH
• Glomerular Filtration Rate MeSH
• Hypertension physiopathology   prevention & control   therapy   MeSH
• Peritoneal Dialysis, Continuous Ambulatory methods   utilization   MeSH
• Creatinine isolation & purification   blood   MeSH
• Quality of Life MeSH
• Humans MeSH
• Renal Replacement Therapy * methods   trends   utilization   MeSH
• Nephrosclerosis epidemiology   complications   physiopathology   MeSH
• Proteinuria diagnosis   etiology   MeSH
• Aging physiology   metabolism   pathology   MeSH
• Statistics as Topic MeSH
• Age Factors * MeSH
• Check Tag
• Humans MeSH