- MeSH
- Biomarkers blood urine MeSH
- Drug Therapy * methods utilization MeSH
- Hemolytic-Uremic Syndrome * diagnosis etiology therapy MeSH
- Disease Attributes MeSH
- Infant MeSH
- Basal Ganglia Hemorrhage diagnosis etiology MeSH
- Humans MeSH
- Magnetic Resonance Imaging methods utilization MeSH
- Antibodies, Monoclonal therapeutic use MeSH
- Parenteral Nutrition methods utilization MeSH
- Peritoneal Dialysis methods utilization MeSH
- Ramipril administration & dosage therapeutic use MeSH
- Salmonella enteritidis isolation & purification pathogenicity MeSH
- Statistics as Topic MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- MeSH
- Asphyxia Neonatorum * diagnosis etiology therapy MeSH
- Biomarkers MeSH
- Diagnostic Techniques, Urological utilization MeSH
- Drug Therapy MeSH
- Infant MeSH
- Humans MeSH
- Interdisciplinary Communication MeSH
- Nephrology MeSH
- Peritoneal Dialysis methods utilization MeSH
- Prognosis * MeSH
- Renal Insufficiency * diagnosis etiology therapy MeSH
- Resuscitation methods MeSH
- Statistics as Topic MeSH
- Respiration, Artificial methods utilization MeSH
- Check Tag
- Infant MeSH
- Humans MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
Renální insuficience je významným faktorem ovlivňujícím schopnost organismu udržovat vnitřní prostředí. V klinicky definovaných případech je u pacientů nutná náhrada eliminační funkce ledvin. Technické metody umožňují eliminaci toxických metabolitů, dochází ovšem také k eliminaci některých léčiv. Z tohoto pohledu je významné posouzení rizika kumulace léčiv u renální insuficience, stejně tak jako vlivu eliminační metody na clearance látek a přizpůsobení dávky, případně intervalu dávkování. Pro odhad eliminace léčiva je nezbytné zohlednit jak vlastnosti použité eliminační metody, tak farmakokinetické parametry léčiva.
Renal insufficiency is a significant factor affecting body's ability to maintain the internal homeostasis. In clinically defined cases, renal replacement therapy is required. Technical methods allow not only the elimination of toxic metabolites but also the elimination of certain drugs. According to this, it is crucial to determine the drug cummulation risk. In addition, quantitative drug clearance provided by the elimination method is as much relevant in order to provide dose and interval adjustment. To estimate drug elimination, both properties of the elimination methods and pharmacokinetic parameters of the drug should be taken into account.
- MeSH
- Renal Dialysis * methods trends utilization MeSH
- Renal Elimination * physiology drug effects MeSH
- Pharmacokinetics MeSH
- Hemodiafiltration methods trends utilization MeSH
- Hemofiltration methods trends utilization MeSH
- Pharmaceutical Preparations metabolism MeSH
- Humans MeSH
- Interdisciplinary Communication MeSH
- Renal Replacement Therapy * methods instrumentation utilization MeSH
- Peritoneal Dialysis methods trends utilization MeSH
- Renal Insufficiency diagnosis complications therapy MeSH
- Statistics as Topic MeSH
- Kidney Transplantation methods trends utilization MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Ledviny se podílí na odstraňování toxických látek z organismu a na udržení stálého vnitřního prostředí. Při akutní nebo chronické renální nedostatečnosti se objevuje celá řada komplikací, které ovlivňují funkci celého organismu. Kardiorenální syndrom je stav, kdy jsou postiženy ledviny a kardiovaskulární aparát. Podle etiologie a klinického průběhu existuje 5 typu kardiorenálního syndromu. Akutní nebo chronické selhání jednoho orgánu může vést k selhání druhého orgánu. Léčba pacientů s kardiorenálním syndromem je komplikovaná a měla by být vedena podle příčiny kardiologem a nefrologem. Strategie léčby je společná a cílem je zlepšení stavu pacienta.
The kidneys play an important role in removing toxic substances from the body and in maintaining water and electrolyte balance.Various body systems are affected by complications arising from the acute or chronic renal insufficiency. Cardiorenal syndromeis defined as a combined disorder of the kidneys and of the cardiovascular system. It is classified into five subtypes primarilybased upon the organ that initiated the insult as well as the clinical presentation. Acute or chronic dysfunction in one organ mayinduce acute or chronic dysfunction of the other. The treatment of patients with cardiorenal syndrome is challenging. The treatingphysician should be either cardiologist or nephrologist, based on the cause of the syndrome. The joint strategy of the treatmentshould be applied and the goal is to achieve the clinical improvement of the patients' health status.
- MeSH
- Acute Kidney Injury * drug therapy complications MeSH
- Hypertension prevention & control MeSH
- Sodium Potassium Chloride Symporter Inhibitors adverse effects MeSH
- Cardio-Renal Syndrome * etiology drug therapy classification complications MeSH
- Cardiotonic Agents therapeutic use MeSH
- Humans MeSH
- Interdisciplinary Communication MeSH
- Peritoneal Dialysis utilization MeSH
- Kidney Transplantation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Review MeSH
Akútne renálne zlyhanie a akútne obličkové poškodenie predstavujú jeden z najzávažnejších medicínskych problémov. Vyžadujú spoluprácu špecialistov, často aj náročnú nemocničnú starostlivosť na jednotkách intenzívnej starostlivosti (vrátane mimotelovej eliminačnej liečby). Pacienti postihnutí týmto ochorením majú vysokú pravdepodobnosť rozvoja chronického ochorenia obličiek v budúcnosti, taktiež vysokú úmrtnosť a v prípade prežitia môžu mať závažné komplikácie a následky. V snahe uľahčiť nám starostlivosť o takýchto pacientov boli vytvorené odporúčania KDIGO (Kidney Disease: Improving Global Outcomes) v roku 2012. V nasledujúcom texte približujeme súčasnú definíciu, epidemiológiu, rizikové faktory, klasifikáciu, diagnostiku a liečbu ochorenia.
Acute renal failure and acute kidney injury represent one of the most serious medical problems. They require the collaboration of specialists and they often require difficult hospital care at the intensive care units (including extracorporeal elimination therapy). Patients with this disease have high probability of progress to chronic kidney disease in the future, they also have high mortality and in the case of survival they can have significant complications and consequences. In ambition to make easy care about these patients there have been created guidelines by KDIGO (Kidney Disease: Improving Global Outcomes) in 2012. In the following text we bring closer actual definition, epidemiology, risk factors, classification, diagnostics and therapy of this disease.
- MeSH
- Renal Dialysis * methods utilization MeSH
- Hemodialysis, Home methods utilization MeSH
- Humans MeSH
- Disease Management MeSH
- Peritoneal Dialysis methods utilization MeSH
- Surveys and Questionnaires MeSH
- Renal Insufficiency * therapy MeSH
- Age Factors MeSH
- Patient Selection MeSH
- Check Tag
- Humans MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
- MeSH
- Hemodialysis, Home * utilization MeSH
- Congresses as Topic MeSH
- Peritoneal Dialysis * utilization MeSH
- Publication type
- News MeSH
- MeSH
- Dialysis * MeSH
- Hemodialysis Units, Hospital * MeSH
- Congresses as Topic MeSH
- Humans MeSH
- Nephrology * organization & administration manpower trends MeSH
- Hospital Departments MeSH
- Peritoneal Dialysis * utilization MeSH
- Societies, Medical MeSH
- Kidney Transplantation MeSH
- Check Tag
- Humans MeSH
- Publication type
- Newspaper Article MeSH
