OBJECTIVE: To describe the clinical and ultrasound characteristics of uterine sarcomas. METHODS: This was a retrospective multicenter study. From the databases of 13 ultrasound centers, we identified patients with a histological diagnosis of uterine sarcoma with available ultrasound reports and ultrasound images who had undergone preoperative ultrasound examination between 1996 and 2016. As the first step, each author collected information from the original ultrasound reports from his/her own center on predefined ultrasound features of the tumors and by reviewing the ultrasound images to identify information on variables not described in the original report. As the second step, 16 ultrasound examiners reviewed the images electronically in a consensus meeting and described them using predetermined terminology. RESULTS: We identified 116 patients with leiomyosarcoma, 48 with endometrial stromal sarcoma and 31 with undifferentiated endometrial sarcoma. Median age of the patients was 56 years (range, 26-86 years). Most patients were symptomatic at diagnosis (164/183 (89.6%)), the most frequent presenting symptom being abnormal vaginal bleeding (91/183 (49.7%)). Patients with endometrial stromal sarcoma were younger than those with leiomyosarcoma and undifferentiated endometrial sarcoma (median age, 46 years vs 57 and 60 years, respectively). According to the assessment by the original ultrasound examiners, the median diameter of the largest tumor was 91 mm (range, 7-321 mm). Visible normal myometrium was reported in 149/195 (76.4%) cases, and 80.0% (156/195) of lesions were solitary. Most sarcomas (155/195 (79.5%)) were solid masses (> 80% solid tissue), and most manifested inhomogeneous echogenicity of the solid tissue (151/195 (77.4%)); one sarcoma was multilocular without solid components. Cystic areas were described in 87/195 (44.6%) tumors and most cyst cavities had irregular walls (67/87 (77.0%)). Internal shadowing was observed in 42/192 (21.9%) sarcomas and fan-shaped shadowing in 4/192 (2.1%). Moderate or rich vascularization was found on color-Doppler examination in 127/187 (67.9%) cases. In 153/195 (78.5%) sarcomas, the original ultrasound examiner suspected malignancy. Though there were some differences, the results of the first and second steps of the analysis were broadly similar. CONCLUSIONS: Uterine sarcomas typically appear as solid masses with inhomogeneous echogenicity, sometimes with irregular cystic areas but only very occasionally with fan-shaped shadowing. Most are moderately or very well vascularized. Copyright © 2019 ISUOG. Published by John Wiley & Sons Ltd.

• MeSH
• Adult MeSH
• Sarcoma, Endometrial Stromal diagnostic imaging   pathology   MeSH
• Leiomyosarcoma diagnostic imaging   pathology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Uterine Neoplasms diagnostic imaging   pathology   MeSH
• Endometrial Neoplasms diagnostic imaging   pathology   MeSH
• Retrospective Studies MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Ultrasonography, Doppler, Color MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Aged, 80 and over MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Multicenter Study MeSH

• Keywords
• Carneyova triáda,
• MeSH
• Biopsy * methods   MeSH
• Chondroma diagnosis   MeSH
• Diagnostic Errors * MeSH
• Diagnosis, Differential MeSH
• Echinococcosis, Hepatic diagnosis   MeSH
• Gastrointestinal Stromal Tumors diagnosis   drug therapy   surgery   MeSH
• Histological Techniques * MeSH
• Carcinoma, Renal Cell diagnosis   surgery   MeSH
• Comorbidity MeSH
• Leiomyosarcoma diagnostic imaging   surgery   MeSH
• Humans MeSH
• Sarcoma * diagnostic imaging   diagnosis   surgery   MeSH
• Seminoma diagnosis   MeSH
• Check Tag
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Case Reports MeSH

BACKGROUND/AIM: Primary hepatic leiomyosarcoma is an extremely rare type of liver sarcoma with relatively poor prognosis, with about 50 cases having been reported in the literature. Potential origins of this tumor in the liver are the smooth muscle cells in the round ligament, intrahepatic blood vessels and intrahepatic bile ducts. There is no apparent sex predilection and there is a wide age range. The clinical presentation is not specific and the diagnosis depends on the expression of markers such as smooth muscle actin, desmin and vimentin by tumor cells. PATIENTS AND METHODS: Herein, we present a case of a bulky primary hepatic leiomyosarcoma in a 68-year-old female patient. The patient underwent resection of the exophytic mass en block with the hepatic segments III and IVB. CONCLUSION: Surgical resection is the most effective among the treatment options.

• MeSH
• Chemotherapy, Adjuvant MeSH
• Fatal Outcome MeSH
• Leiomyosarcoma diagnostic imaging   drug therapy   pathology   surgery   MeSH
• Humans MeSH
• Magnetic Resonance Imaging MeSH
• Liver Neoplasms diagnostic imaging   drug therapy   pathology   surgery   MeSH
• Tomography, X-Ray Computed MeSH
• Aged MeSH
• Check Tag
• Humans MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Case Reports MeSH
• Review MeSH

V článku popisujeme případ pacientky s náhodně sonograficky detekovaným tumorem horního pólu levé ledviny při došetřování bolestí pravého hypogastria a dyspeptických potíží v červenci 2011. Vzdálená diseminace byla předoperačně provedenými zobrazovacími metodami vyloučena. Po provedení levostranné transperitoneální radikální nefrektomie byl definitivní histopatologický nález uzavřen jako leiomyosarkom ledviny low grade, lymfatické uzliny byly negativní. I přes špatnou prognózu u těchto typů tumorů je pacientka nyní 5 let bez detekce lokální recidivy či metastáz.

The authors describe the case of a patient with the tumor of the upper pole of the left kidney, incidentally detected sonographically, which was performed in July 2011 due to a right hypogastric pain. There were no dissemination detected by imaging before operation. Histologically, after the left-sided radical transperitoneal nephrectomy, there was confirmed leiomyosarcoma of the kidney – low grade, no lymph nodes was positive. Even though the bad prognosis of these tumor group, the patient is right now 5 years after the nephrectomy with no detection of a local recurrence or metastases.

• MeSH
• Leiomyosarcoma * diagnostic imaging   surgery   pathology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Kidney Neoplasms * diagnostic imaging   surgery   pathology   MeSH
• Nephrectomy MeSH
• Disease-Free Survival MeSH
• Treatment Outcome MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Female MeSH
• Publication type
• Case Reports MeSH