• Klíčová slova
• kognitivní screening, trénink paměti,
• MeSH
• bolesti hlavy MeSH
• cvičení MeSH
• kognice MeSH
• kognitivní dysfunkce diagnostické zobrazování   diagnóza   terapie   MeSH
• migréna diagnostické zobrazování   diagnóza   etiologie   farmakoterapie   klasifikace   komplikace   mozkomíšní mok   ošetřování   patofyziologie   terapie   MeSH
• paměť MeSH
• poruchy paměti diagnostické zobrazování   diagnóza   rehabilitace   terapie   MeSH
• testy pro posouzení mentálních funkcí a demence MeSH
• Publikační typ
• kazuistiky MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Publikační typ
• závěrečné práce

OBJECTIVE: The aim of the present study was to investigate if prospective memory (PM) is impaired in idiopathic rapid eye movement (REM) sleep behavior disorder (iRBD). RBD is a parasomnia characterized by dream enactment and by REM sleep without muscle atonia. iRBD is considered as the initial stage of neurodegeneration with pathological storage of alpha-synuclein. METHOD: Sixty iRBD patients with polysomnography-confirmed RBD without parkinsonism and dementia and 30 demographically matched normal controls (NC) were enrolled in the present study. Clinical assessment included Movement Disorders Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS), dopamine transporter single-photon emission computed tomography (DaT-SPECT) for imaging synapses of dopaminergic neurons in the striatum and a neuropsychological battery with embedded time-based and event-based PM measures. RESULTS: iRBD differed significantly from NC in event-based PM, a number of event-based failures to recall intention and total PM performance (all p < .001) but did not differ in time-based PM and recognition. PM did not contribute to impairment of instrumental activities of daily living in iRBD. Despite being preserved in iRBD in comparison to NC, time-based PM correlated significantly with dopaminergic neuronal loss measured by DaT-SPECT. CONCLUSIONS: We show evidence for a differential pattern of PM impairment in iRBD with severe impairment of event-based and concurrent preservation of time-based PM. We theorize that event-based PM impairment in iRBD is caused by severe impairment of retention and recognition mechanisms in episodic memory whereas time-based PM seems to be affected by reduced striatal dopaminergic synapses.

• MeSH
• činnosti denního života psychologie   MeSH
• epizodická paměť * MeSH
• jednofotonová emisní výpočetní tomografie metody   MeSH
• lidé středního věku MeSH
• lidé MeSH
• neuropsychologické testy MeSH
• polysomnografie metody   MeSH
• porucha chování v REM spánku diagnostické zobrazování   epidemiologie   psychologie   MeSH
• poruchy paměti diagnostické zobrazování   epidemiologie   psychologie   MeSH
• senioři MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

• MeSH
• emoční expresivita MeSH
• hipokampus fyziologie   MeSH
• lidé MeSH
• magnetická rezonanční tomografie MeSH
• modely u zvířat MeSH
• myši MeSH
• neuroplasticita fyziologie   MeSH
• paměť * fyziologie   klasifikace   MeSH
• podmiňování (psychologie) MeSH
• poruchy paměti diagnostické zobrazování   patofyziologie   patologie   MeSH
• Check Tag
• lidé MeSH
• myši MeSH
• Publikační typ
• novinové články MeSH

Methanol poisoning leads to lesions in the basal ganglia and subcortical white matter, as well as to demyelination and atrophy of the optic nerve. However, information regarding cognitive deficits in a large methanol sample is lacking. The principal aim of the present study was to identify the cognitive sequelae of methanol poisoning and their morphological correlates. A sample of 50 patients (METH; age 48 ± 13 years), 3-8 months after methanol poisoning, and 57 control subjects (CS; age 49 ± 13 years) were administered a neuropsychological battery. Forty-six patients were followed in 2 years' perspective. Patients additionally underwent 1.5T magnetic resonance imaging (MRI). Three biochemical and toxicological metabolic markers and a questionnaire regarding alcohol abuse facilitated the classification of 24 patients with methanol poisoning without alcohol abuse (METHna) and 22 patients with methanol poisoning and alcohol abuse (METHa). All groups were compared to a control group of similar size, and matched for age, education, premorbid intelligence level, global cognitive performance, and level of depressive symptoms. Using hierarchical multiple regression we found significant differences between METH and CS, especially in executive and memory domains. METHa showed a similar pattern of cognitive impairment with generally more severe executive dysfunction. Moreover, all METH patients with extensive involvement on brain MRI (lesions in ≥2 anatomical regions) had a more severe cognitive impairment. From a longitudinal perspective, we did not find any changes in their cognitive functioning after 2 years' follow-up. Our findings suggest that methanol poisoning is associated with executive dysfunction and explicit memory impairment, supposedly due to basal ganglia dysfunction and disruption of frontostriatal circuitry proportional to the number of brain lesions, and that these changes are persistent after 2 years' follow-up.

• MeSH
• časové faktory MeSH
• dospělí MeSH
• exekutivní funkce * MeSH
• kognitivní poruchy chemicky indukované   diagnostické zobrazování   psychologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• longitudinální studie MeSH
• methanol otrava   MeSH
• následné studie MeSH
• neuropsychologické testy MeSH
• poruchy paměti chemicky indukované   diagnostické zobrazování   psychologie   MeSH
• průřezové studie MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH