Chronic obstructive pulmonary disease (COPD) is a progressive and disabling disease that has been associated with aging. Several factors may potentially impair performance during exercise in elderly patients with COPD. This study was conducted to evaluate what characteristics related to lung function, peripheral muscle strength and endurance can predict the performance of elderly patients with COPD during cardiopulmonary exercise testing (CPET). Forty elderly patients with COPD underwent resting lung function tests, knee isokinetic dynamometry, and CPET. Three models were developed to explain the variability in peak oxygen uptake (VO(2) peak) after controlling for age as an independent confounder. The pulmonary function model showed the highest explained variance (65.6 %); in this model, ventilation distribution (p<0.001) and pulmonary diffusion (0.013) were found to be independent predictors. Finally, the models that included the muscle strength and endurance variables presented explained variances of 51 % and 57.4 %, respectively. In these models that involved muscular dysfunction, however, only the endurance variables were found to be independent predictors (p<0.05). In conclusion, ventilation distribution and pulmonary diffusion, but not the degree of airway obstruction, independently predict CPET performance in elderly patients with COPD. In addition, peripheral muscle endurance, but not strength, also predicts CPET performance in these subjects.
- MeSH
- Pulmonary Disease, Chronic Obstructive diagnosis physiopathology MeSH
- Pulmonary Diffusing Capacity methods physiology MeSH
- Physical Endurance physiology MeSH
- Middle Aged MeSH
- Humans MeSH
- Pulmonary Ventilation physiology MeSH
- Cross-Sectional Studies MeSH
- Respiratory Function Tests methods MeSH
- Aged MeSH
- Oxygen Consumption physiology MeSH
- Muscle Strength physiology MeSH
- Exercise Tolerance physiology MeSH
- Exercise Test methods MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
INTRODUCTION: Immune response probably changes during human life, being influenced by cumulative exposure to environmental factors and individual genetic background. METHODS: Patients investigated for suspected interstitial lung disease were prospectively enrolled. After completing the diagnostic process, 121 patients were diagnosed extrinsic allergic alveolitis (EAA) and 136 sarcoidosis. Three groups according to age were established (<30 years, 30-60 years, >60 years), clinical manifestation, vital capacity (VC), forced expired volume in 1 s (FEV1 ), lung diffusing capacity for carbon monoxide-transfer factor (TLCO ) and bronchoalveolar lavage fluid (BALF) differential cell count were compared among the groups. RESULTS: Age subgroups of EAA patients did not significantly differ in lung functions. In the group above 60 years, non-significantly higher neutrophils and eosinophils counts and CD4/CD8 ratio were observed. Sarcoidosis patients were significantly younger than EAA group and had significantly better lung functions (VC, FEV1 , TLCO ). Patients with sarcoidosis above 60 years of age had significantly higher percentages of neutrophils in BALF compared with younger patients. BALF percentage of neutrophils positively correlated with age. CONCLUSIONS: Presented results may support the hypothesis that reactivity of immune system changes during the life, which may result in different manifestation of interstitial lung diseases according to age.
- MeSH
- Bronchoalveolar Lavage Fluid cytology MeSH
- Pulmonary Diffusing Capacity physiology MeSH
- Adult MeSH
- Eosinophils MeSH
- Alveolitis, Extrinsic Allergic complications pathology physiopathology MeSH
- Cohort Studies MeSH
- Middle Aged MeSH
- Humans MeSH
- Neutrophils MeSH
- Sarcoidosis, Pulmonary complications pathology physiopathology MeSH
- CD4-CD8 Ratio MeSH
- Aged MeSH
- Forced Expiratory Volume physiology MeSH
- Age Factors MeSH
- Vital Capacity physiology MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
20 s. : barev. il. ; 21 cm
- MeSH
- Pulmonary Diffusing Capacity physiology methods instrumentation MeSH
- Clinical Medicine MeSH
- Respiratory Function Tests methods trends utilization MeSH
- Publication type
- Handbook MeSH
- Conspectus
- Fyziologie člověka a srovnávací fyziologie
- NML Fields
- fyziologie
- pneumologie a ftizeologie
- MeSH
- Pulmonary Disease, Chronic Obstructive diagnosis complications MeSH
- Pulmonary Diffusing Capacity physiology methods MeSH
- Drug Therapy methods statistics & numerical data utilization MeSH
- Middle Aged MeSH
- Humans MeSH
- Spirometry methods statistics & numerical data utilization MeSH
- Statistics as Topic MeSH
- Severity of Illness Index MeSH
- Forced Expiratory Volume physiology MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Meeting Abstract MeSH
