Depresivní a úzkostné poruchy jsou rizikovým faktorem pro rozvoj kardiovaskulárních poruch. Naše výsledky získané metodou EKG mapování – diagnostický systém Cardiac 111,2 – ukazují změny u neléčených pacientů s panickými poruchami a u pacientů s depresivní poruchou v remisi, léčených tricyklickými antidepresivy. Tyto změny zahrnují tachykardii, změny parametrů DIAM max 40 (časná depolarizační fáze) a otevřený úhel QRS–STT. Závažnost těchto změn koreluje s dávkou, resp. hladinou tricyklického antidepresiva (dosulepinu) v profylaktických dávkách. Plazmatická hladina tricyklického antidepresiva koreluje se změnami QT disperse. Naše výsledky ukazují rovněž přímý vztah mezi panickou poruchou a ovlivněním parametrů EKG mapování. Výsledky svědčí pro aktivaci sympatoadrenálního systému.
- MeSH
- Antidepressive Agents, Tricyclic administration & dosage therapeutic use MeSH
- Depression complications MeSH
- Adult MeSH
- Dothiepin pharmacokinetics blood metabolism MeSH
- Cardiovascular Diseases diagnosis complications MeSH
- Comorbidity MeSH
- Middle Aged MeSH
- Humans MeSH
- Panic Disorder diagnosis drug therapy complications MeSH
- Premedication utilization MeSH
- Anxiety diagnosis drug therapy complications MeSH
- Vectorcardiography methods utilization MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Female MeSH
Diabetes mellitus is a risk factor of cardiovascular diseases. ECG of patients with diabetes mellitus type 1 (DM 1) shows tachycardia (block of parasympathetic innervation) and abnormal repolarization (increased QT interval and QT dispersion (QTd)) indicating a risk of ventricular tachycardia and sudden death in young people with DM 1. The aim of the present report was to measure 145 parameters of the heart electric field in 22 patients (14 men, 8 women) with DM 1 without complications (mean age 32.8±11.4 years) and in 22 controls (11 men, 11 women, mean age 30.1±3.4 years). The duration of diabetes was 13.9±7.8 years. The parameters were registered by the diagnostic system Cardiag 112.2 and statistically evaluated by the Student and Mann-Whitney test. Tachycardia (86.3±2.7 beats.min-1), shortening of both QRS (79.9±1.6 ms) and QT (349.0±5.9 ms) and increased QT dispersion (115±36 ms) were observed in DM 1 when compared with the controls (75.0±2.1 beats. min.-1, QRS 89.9±2.7 ms, QT 374.0±4.4 ms, QTd 34.0±12.0 ms, p<0.01). The QTc was 415.2±4.1 ms in DM 1 and 401.4±6.6 ms in controls (NS). Other significant findings in DM 1 were: higher maximum of depolarization isopotential maps (DIPMmax) in the initial phase of QRS and less positive in the terminal phase, more negative minimum (DIPMmin) during QRS similarly as the minimum in depolarization isointegral maps (DIIMmin) and the minimum in isointegral map of the Q wave (Q-IIMmin), lower maximum in repolarization isopotential maps (RIPMmax) and less negative minimum (RIPMmin), more negative amplitude of Q wave (Q-IPMAM) and more pronounced spread of depolarization (activation time). Our results confirmed a decreased parasympathetic to sympathetic tone ratio (tachycardia, shortening of the activation time) and revealed different depolarization and repolarization patterns in DM 1. The differences in heart electric field parameters measured by the BSPM method in DM 1 and in the controls indicate the importance of ECG examination of diabetic patients type 1 in the prevention of cardiovascular diseases.
- MeSH
- Diabetes Mellitus MeSH
- Electrocardiography methods utilization MeSH
- Financing, Organized utilization MeSH
- Data Interpretation, Statistical MeSH
- Insulin therapeutic use MeSH
- Cardiovascular Diseases diagnosis complications MeSH
- Body Surface Potential Mapping methods utilization MeSH
- Vectorcardiography methods utilization MeSH
- MeSH
- Algorithms MeSH
- Electrocardiography methods trends utilization MeSH
- Humans MeSH
- Signal Processing, Computer-Assisted instrumentation MeSH
- Arrhythmias, Cardiac diagnosis classification MeSH
- Heart Rate physiology MeSH
- Statistics as Topic MeSH
- Vectorcardiography methods trends utilization MeSH
- Check Tag
- Humans MeSH
- MeSH
- Electrocardiography methods instrumentation utilization MeSH
- Coronary Stenosis diagnosis physiopathology MeSH
- Humans MeSH
- Logistic Models MeSH
- Signal Processing, Computer-Assisted MeSH
- Sensitivity and Specificity MeSH
- Statistics as Topic methods MeSH
- Vectorcardiography methods instrumentation utilization MeSH
- Check Tag
- Humans MeSH
- Keywords
- dosulepin,
- MeSH
- Antidepressive Agents, Tricyclic administration & dosage pharmacology MeSH
- Electrocardiography drug effects utilization MeSH
- Research Support as Topic MeSH
- Humans MeSH
- Body Surface Potential Mapping drug effects utilization MeSH
- Vectorcardiography drug effects utilization MeSH
- Check Tag
- Humans MeSH
