The number of studies in the literature investigating the effect of tetanus vaccination on rabies prophylaxis is rather limited. In this study, we aimed to investigate the effect of concurrent tetanus-diphtheria (Td) vaccination on the antibody response to rabies vaccine. The data of consecutive 80 patients who presented to Sakarya University Training and Research Hospital, Department of Emergency due to rabies suspected exposure between 15 October 2012 and 12 June 2013 were enrolled to this study. Postexposure rabies prophylaxis had been given to all cases, however concurrent tetanus vaccination had been administered to some of them according to their need. Cases were divided into two parts according to their receipt of tetanus prophylaxis as rabies only group (group R, n=37), and rabies and tetanus-diphtheria group (group R+Td, n=43). Rabies antibody levels were tested in sera of the cases at first and postvaccination 21st day. The median antibody levels of each group were measured and compared with each other statistically. In our study, postvaccination 21st day antibody level of group R was 0.68 IU/ml (IQR: 0.79), while the same for group R+Td was 0.52 IU/ml (IQR: 0.48) (p=0.022). Concurrent administration of Td vaccine was found to have a significant negative effect on the antibody response to rabies vaccine. Our results should be confirmed with further studies including more cases.
- MeSH
- lidé MeSH
- tvorba protilátek * MeSH
- vakcína proti diftérii a tetanu * aplikace a dávkování imunologie MeSH
- vakcína proti vzteklině * imunologie MeSH
- vakcinace MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Nervová sústava je najkomplikovanejšou sústavou nášho organizmu a každé jej poškodenie zanecháva celoživotné následky. Rovnako ako je v neustálom vývoji veda a výskum, vyvíjajú sa aj vírusy. Ich vlastnosti a mechanizmy sa menia a prispôsobujú prostrediu, v ktorom sa nachádzajú. Z toho dôvodu je nevyhnutné študovať molekulárne vlastnosti vírusov, spôsoby, akými sa vyhýbajú imunitnej odpovedi a možnosti terapie a profylaxie. Cieľom nášho článku je podať komplexný prehľad o dvoch neuropatogénnych vírusoch rozšírených takmer po celom svete, víruse besnoty a víruse lymfocytovej choriomeningitídy a ich patogenéze, liečbe a profylaxii.
The nervous system is the most complicated system of our body and any damage leads to lifelong consequences. As well as the tireless development of science and research, evolve viruses too. Their properties and mechanisms of change adapt to the environment, in which they are located. Therefore, it is necessary to study the molecular properties of the viruses, the way they avoid the immune response, and the therapy and prophylaxis. The aim of this work is to give a comprehensive picture of two neuropathogenic viruses extended almost all over the world, rabies virus and lymphocytic choriomeningitis virus, including their pathogenesis, treatment and prophylaxis.
- MeSH
- lidé MeSH
- lymfocytární choriomeningitida * diagnóza etiologie prevence a kontrola terapie MeSH
- rabies * diagnóza etiologie prevence a kontrola terapie MeSH
- vakcína proti vzteklině dějiny farmakologie imunologie terapeutické užití MeSH
- virus lymfocytární choriomeningitidy klasifikace patogenita růst a vývoj MeSH
- virus rabies patogenita růst a vývoj MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Although rabies incidence has fallen sharply over the past decades in Europe, the disease is still present in Eastern Europe. Oral rabies immunization of wild animal rabies has been shown to be the most effective method for the control and elimination of rabies. All rabies vaccines used in Europe are modified live virus vaccines based on the Street Alabama Dufferin (SAD) strain isolated from a naturally-infected dog in 1935. Because of the potential safety risk of a live virus which could revert to virulence, the genetic composition of three commercial attenuated live rabies vaccines was investigated in two independent laboratories using next genome sequencing. This study is the first one reporting on the diversity of variants in oral rabies vaccines as well as the presence of a mix of at least two different variants in all tested batches. The results demonstrate the need for vaccine producers to use new robust methodologies in the context of their routine vaccine quality controls prior to market release.
- MeSH
- atenuované vakcíny * MeSH
- divoká zvířata * MeSH
- genetická variace MeSH
- genom virový MeSH
- nemoci zvířat prevence a kontrola MeSH
- rabies veterinární MeSH
- RNA virová MeSH
- vakcína proti vzteklině genetika imunologie MeSH
- vakcinace veterinární MeSH
- virus rabies genetika imunologie MeSH
- vysoce účinné nukleotidové sekvenování MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Geografické názvy
- Evropa MeSH
- MeSH
- břišní tyfus dějiny imunologie prevence a kontrola MeSH
- cholerové vakcíny dějiny imunologie MeSH
- infekční nemoci dějiny MeSH
- lidé MeSH
- spalničková vakcína MeSH
- vakcína proti diftérii a tetanu dějiny imunologie MeSH
- vakcína proti hepatitidě B dějiny imunologie MeSH
- vakcína proti vzteklině dějiny imunologie MeSH
- vakcinace metody metody trendy MeSH
- vakcíny proti tuberkulóze dějiny imunologie MeSH
- Check Tag
- lidé MeSH
