Mineralized tissues, such as bones or teeth, are essential structures of all vertebrates. They enable rapid movement, protection, and food processing, in addition to providing physiological functions. Although the development, regeneration, and pathogenesis of teeth and bones have been intensely studied, there is currently no tool to accurately follow the dynamics of growth and healing of these vital tissues in space and time. Here, we present the BEE-ST (Bones and tEEth Spatio-Temporal growth monitoring) approach, which allows precise quantification of development, regeneration, remodeling, and healing in any type of calcified tissue across different species. Using mouse teeth as model the turnover rate of continuously growing incisors was quantified, and role of hard/soft diet on molar root growth was shown. Furthermore, the dynamics of bones and teeth growth in lizards, frogs, birds, and zebrafish was uncovered. This approach represents an effective, highly reproducible, and versatile tool that opens up diverse possibilities in developmental biology, bone and tooth healing, tissue engineering, and disease modeling.
- MeSH
- dánio pruhované * MeSH
- kosti a kostní tkáň MeSH
- myši MeSH
- vývoj kostí MeSH
- zubní kořen MeSH
- zuby * fyziologie MeSH
- zvířata MeSH
- Check Tag
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- hybridní můstek,
- MeSH
- biomechanika MeSH
- lidé středního věku MeSH
- lidé MeSH
- podpěry zubní MeSH
- retence zubní protézy * metody MeSH
- viklavost zubů MeSH
- zubní implantáty MeSH
- zubní náhrada ve spojení s implantáty * MeSH
- zubní náhrady částečné fixní * MeSH
- zubní protéza - design MeSH
- zuby-sanace - selhání MeSH
- zuby fyziologie MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
Menarche is an indicator frequently used to study variation in growth, development, and related health conditions among members of living populations. As a life event, menarche is often associated with changes in an individual's social identity. The reproductive lifespan, which for females starts with menarche, is a paramount feature of palaeodemographic studies. Determination of menarche status from the skeletal remains of individuals of past populations can be obtained by assessing the developmental status of the iliac crest, as well as the hand and wrist bones, which are, unlike teeth, often poorly recovered in bioarchaeological contexts. The present study seeks to evaluate the link between dental mineralization and menarche in a population of known menarche status. The relationship between permanent teeth mineralization and menarche status was investigated by using data of developing permanent teeth (167 radiographs) rated in accordance with the well-known standards of Demirjian et al. and Moorrees et al. collected among 73 living French females of known menarcheal status. Using correlation ratios, GLMM and CART algorithm, menarcheal status is correlated with mineralization of the premolars. Menarcheal status is predicted correctly for 92 and 77% of radiographs of the learning and validation samples, respectively. Although promising, the results require caution prior to generalization to other populations. The age of menarche in this particular sample may simply coincide with the development of the premolars in this particular sample. Therefore, further investigation applied to populations with various mean ages of menarche is required in order to provide new evidence of variation in human growth and development from the correspondence between the mineralization of the permanent teeth and menarche.
- MeSH
- algoritmy MeSH
- antropologie fyzická MeSH
- dítě MeSH
- fyziologická kalcifikace fyziologie MeSH
- lidé MeSH
- menarche fyziologie MeSH
- mladiství MeSH
- rentgendiagnostika panoramatická MeSH
- zuby anatomie a histologie diagnostické zobrazování fyziologie MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Chameleon teeth develop as individual structures at a distance from the developing jaw bone during the pre-hatching period and also partially during the post-hatching period. However, in the adult, all teeth are fused together and tightly attached to the jaw bone by mineralized attachment tissue to form one functional unit. Tooth to bone as well as tooth to tooth attachments are so firm that if injury to the oral cavity occurs, several neighbouring teeth and pieces of jaw can be broken off. We analysed age-related changes in chameleon acrodont dentition, where ankylosis represents a physiological condition, whereas in mammals, ankylosis only occurs in a pathological context. The changes in hard-tissue morphology and mineral composition leading to this fusion were analysed. For this purpose, the lower jaws of chameleons were investigated using X-ray micro-computed tomography, laser-induced breakdown spectroscopy and microprobe analysis. For a long time, the dental pulp cavity remained connected with neighbouring teeth and also to the underlying bone marrow cavity. Then, a progressive filling of the dental pulp cavity by a mineralized matrix occurred, and a complex network of non-mineralized channels remained. The size of these unmineralized channels progressively decreased until they completely disappeared, and the dental pulp cavity was filled by a mineralized matrix over time. Moreover, the distribution of calcium, phosphorus and magnesium showed distinct patterns in the different regions of the tooth-bone interface, with a significant progression of mineralization in dentin as well as in the supporting bone. In conclusion, tooth-bone fusion in chameleons results from an enhanced production of mineralized tissue during post-hatching development. Uncovering the developmental processes underlying these outcomes and performing comparative studies is necessary to better understand physiological ankylosis; for that purpose, the chameleon can serve as a useful model species.
10th edition x, 350 s., [32] s. : il., tab. ; 28 cm
- MeSH
- zubní okluze MeSH
- zuby anatomie a histologie fyziologie MeSH
- Publikační typ
- monografie MeSH
- příručky MeSH
- Konspekt
- Stomatologie
- NLK Obory
- anatomie
- fyziologie
- zubní lékařství
- NLK Publikační typ
- učebnice vysokých škol
Tooth development has attracted the attention of researchers since the 19th century. It became obvious even then that morphogenesis could not fully be appreciated from two-dimensional histological sections. Therefore, methods of three-dimensional (3D) reconstructions were employed to visualize the surface morphology of developing structures and to help appreciate the complexity of early tooth morphogenesis. The present review surveys the data provided by computer-aided 3D analyses to update classical knowledge of early odontogenesis in the laboratory mouse and in humans. 3D reconstructions have demonstrated that odontogenesis in the early stages is a complex process which also includes the development of rudimentary odontogenic structures with different fates. Their developmental, evolutionary, and pathological aspects are discussed. The combination of in situ hybridization and 3D reconstruction have demonstrated the temporo-spatial dynamics of the signalling centres that reflect transient existence of rudimentary tooth primordia at loci where teeth were present in ancestors. The rudiments can rescue their suppressed development and revitalize, and then their subsequent autonomous development can give rise to oral pathologies. This shows that tooth-forming potential in mammals can be greater than that observed from their functional dentitions. From this perspective, the mouse rudimentary tooth primordia represent a natural model to test possibilities of tooth regeneration.
- MeSH
- biologická evoluce MeSH
- dentice MeSH
- diastema embryologie MeSH
- hybridizace in situ metody MeSH
- lidé MeSH
- myši MeSH
- odontogeneze * genetika fyziologie MeSH
- počítačové zpracování obrazu MeSH
- regenerace MeSH
- zobrazování trojrozměrné metody MeSH
- zuby přespočetné embryologie MeSH
- zuby embryologie fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
Tooth absence and defects caused by various reasons are frequent events in humans. They are not life threatening but may bring about social consequences. Recent dentistry provides solutions in the form of prosthetics or dental implants; however, several complications and distinct limitations favour bioengineering of dental and periodontal structures. At least two types of cells (epithelial and mesenchymal) have to be recombined to produce a new functional tooth. Moreover, the tooth must be vascularized, innervated and properly anchored in the bone. To study these issues, different approaches have been established in both basic and applied research. In this review, recent strategies and techniques of tooth engineering are comprehensively summarized and discussed, particularly regarding manipulation using stem cells.
- MeSH
- implantace protézy MeSH
- kmenové buňky cytologie MeSH
- lidé MeSH
- tkáňové inženýrství metody trendy MeSH
- tkáňové podpůrné struktury MeSH
- výzkum * MeSH
- zuby fyziologie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
- MeSH
- archeologie dějiny metody MeSH
- kulturní antropologie MeSH
- lidé MeSH
- muzea * MeSH
- náboženství MeSH
- okultismus MeSH
- rytectví a rytiny MeSH
- umění * MeSH
- zubní lékařství MeSH
- zuby * fyziologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- historické články MeSH
1st publ. 535 s., [8] s. obr. příl. : il. (některé barev.) ; 24 cm + 1 DVD
- MeSH
- centrální nervový systém fyziologie MeSH
- mozek fyziologie MeSH
- zuby fyziologie inervace MeSH
- Publikační typ
- monografie MeSH
- Konspekt
- Hygiena. Lidské zdraví
- NLK Obory
- fyziologie
- zubní lékařství
- neurologie
