• Klíčová slova
• angličtina - němčina,
• MeSH
• lingvistika MeSH
• Publikační typ
• slovník vícejazyčný MeSH

• Konspekt
• Lingvistika. Jazyky
• NLK Obory
• lingvistika, lékařská terminologie

• Konspekt
• Ortopedie. Chirurgie. Oftalmologie
• NLK Obory
• radiologie, nukleární medicína a zobrazovací metody
• ortopedie

• MeSH
• lékařská etika MeSH
• lékařství v literatuře MeSH
• potrat nezákonný MeSH
• vražda MeSH
• Publikační typ
• beletrie MeSH

• Konspekt
• Německá próza, německy psaná
• NLK Obory
• humanitní vědy a umění
• lékařství
• etika, bioetika, lékařská etika

• MeSH
• antigeny CD279 analýza   MeSH
• antigeny CD4 analýza   MeSH
• antigeny CD8 analýza   MeSH
• lidé MeSH
• mycosis fungoides imunologie   MeSH
• nádorové biomarkery analýza   MeSH
• nádory kůže imunologie   MeSH
• T-lymfocyty pomocné-indukující imunologie   MeSH
• Check Tag
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• dopisy MeSH
• komentáře MeSH

BACKGROUND: Restless legs syndrome (RLS) is associated with common variants in three intronic and intergenic regions in MEIS1, BTBD9, and MAP2K5/LBXCOR1 on chromosomes 2p, 6p and 15q. METHODS: Our study investigated these variants in 649 RLS patients and 1230 controls from the Czech Republic (290 cases and 450 controls), Austria (269 cases and 611 controls) and Finland (90 cases and 169 controls). Ten single nucleotide polymorphisms (SNPs) within the three genomic regions were selected according to the results of previous genome-wide scans. Samples were genotyped using Sequenom platforms. RESULTS: We replicated associations for all loci in the combined samples set (rs2300478 in MEIS1, p = 1.26 x 10(-5), odds ratio (OR) = 1.47, rs3923809 in BTBD9, p = 4.11 x 10(-5), OR = 1.58 and rs6494696 in MAP2K5/LBXCOR1, p = 0.04764, OR = 1.27). Analysing only familial cases against all controls, all three loci were significantly associated. Using sporadic cases only, we could confirm the association only with BTBD9. CONCLUSION: Our study shows that variants in these three loci confer consistent disease risks in patients of European descent. Among the known loci, BTBD9 seems to be the most consistent in its effect on RLS across populations and is also most independent of familial clustering.

• MeSH
• dospělí MeSH
• frekvence genu MeSH
• genetická predispozice k nemoci MeSH
• genotyp MeSH
• homeodoménové proteiny genetika   MeSH
• jednonukleotidový polymorfismus * MeSH
• lidé středního věku MeSH
• lidé MeSH
• MAP kinasa-kinasa 5 genetika   MeSH
• nádorové proteiny genetika   MeSH
• odds ratio MeSH
• represorové proteiny MeSH
• senioři MeSH
• syndrom neklidných nohou * genetika   MeSH
• transkripční faktory genetika   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• multicentrická studie MeSH
• práce podpořená grantem MeSH
• Geografické názvy
• Česká republika MeSH
• Finsko MeSH
• Rakousko MeSH

We describe 11 poroid neoplasms with sebaceous differentiation, including a metaplastic (sarcomatoid) carcinoma arising in association with an apocrine poroma. Six lesions had the silhouette of a classical poroma, 3 of poroid hidradenoma and 1 of dermal duct tumor. In all cases, sebaceous differentiation was identified as clustered or solitary, mature sebocytes occurring mainly at the periphery of intradermal cellular aggregations, accompanied by sebaceous ducts. In one poroma, clusters of sebocytes were seen within intradermal aggregates and intraepidermally. In 1 of the 3 poroid hidradenomas, the eosinophilic cuticle lining the cyst was crenulated in foci associated with sebocytes. In none of the cases were there signs of follicular differentiation. One poroma, in addition to sebaceous differentiation, showed decapitation secretion in some ductular structures. The single carcinoma was an ulcerated oval to spindle cell neoplasm surrounded laterally by the residuum of a poroma containing groups of sebocytes. The epithelial islands of the poroma were prominently keratinized and blended gradually with the pleomorphic cells of the metaplastic carcinoma that immunohistochemically stained focally for cytokeratins and simultaneously showed strong vimentin expression. Our study supports previous findings that sebaceous differentiation can be identified not only in classical poroma but also in the related lesions known as dermal duct tumor and poroid hidradenoma. Occurrence of metaplastic carcinoma in association with apocrine poroma is a rare event which indicates the existence of a malignant counterpart of the latter entity, which can be descriptively referred to as "sarcomatoid apocrine porocarcinoma."

• MeSH
• adenom potní žlázy patologie   MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mazové žlázy patologie   MeSH
• mnohočetné primární nádory patologie   MeSH
• nádory kůže patologie   MeSH
• sarkom patologie   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

BACKGROUND: With the exception of erythema migrans, Borrelia infection of the skin manifests much more commonly with B cell-rich infiltrates. T cell-rich lesions have rarely been described. OBJECTIVE: We report a series of 6 patients with cutaneous borreliosis presenting with T cell-predominant skin infiltrates. METHODS: We studied the clinicopathologic and molecular features of 6 patients with T cell-rich skin infiltrates. RESULTS: Half of the patients had erythematous patchy, partly annular lesions, and the other patients had features of acrodermatitis chronica atrophicans. Histopathology revealed a dense, band-like or diffuse dermal infiltrate. Apart from small, well differentiated lymphocytes, there were medium-sized lymphocytes with slight nuclear atypia and focal epidermotropism. An interstitial histiocytic component was found in 4 cases, including histiocytic pseudorosettes. Fibrosis was present in all cases but varied in severity and distribution. In 5 patients, borrelia DNA was detected in lesional tissue using polymerase chain reaction studies. No monoclonal rearrangement of T-cell receptor gamma genes was found. LIMITATIONS: This retrospective study was limited by the small number of patients. CONCLUSION: In addition to unusual clinical presentation, cutaneous borreliosis can histopathologically manifest with a T cell-rich infiltrate mimicking cutaneous T-cell lymphoma. Awareness of this clinicopathologic constellation is important to prevent underrecognition of this rare and unusual presentation representing a Borrelia-associated T-cell pseudolymphoma.

• MeSH
• akrodermatitida etiologie   MeSH
• bakteriální nemoci kůže diagnóza   imunologie   patologie   MeSH
• Borrelia burgdorferi izolace a purifikace   MeSH
• chronická lymfatická leukemie komplikace   MeSH
• diferenciální diagnóza MeSH
• DNA bakterií izolace a purifikace   MeSH
• dospělí MeSH
• erytém etiologie   MeSH
• fibróza MeSH
• histiocyty patologie   MeSH
• kousnutí klíštětem komplikace   mikrobiologie   patologie   MeSH
• kožní T-buněčný lymfom diagnóza   MeSH
• kůže imunologie   mikrobiologie   patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lymeská nemoc komplikace   diagnóza   imunologie   patologie   přenos   MeSH
• pseudolymfom diagnóza   imunologie   patologie   MeSH
• receptory antigenů T-buněk gama-delta genetika   MeSH
• retrospektivní studie MeSH
• senioři MeSH
• T-lymfocyty patologie   MeSH
• zvířata MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH

• MeSH
• angioplastika metody   statistika a číselné údaje   MeSH
• infarkt myokardu mortalita   terapie   MeSH
• lidé MeSH
• mortalita statistika a číselné údaje   trendy   MeSH
• trombolytická terapie metody   statistika a číselné údaje   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• srovnávací studie MeSH

• MeSH
• farmakologie MeSH

• Konspekt
• Farmacie. Farmakologie
• NLK Obory
• farmacie
• NLK Publikační typ
• příručky

Mixed tumor, eccrine type, is a rare cutaneous adnexal neoplasm, mostly reported as isolated case reports. A systematic analysis of its histopathologic and immunohistochemical features has not previously been performed on a large series. The purpose of our investigation was to study a large number of cutaneous eccrine mixed tumors so as to fully characterize the entire spectrum of changes in the epithelial and stromal components, with an emphasis on unusual histopathologic features that may represent a diagnostic pitfall. This article reports a light microscopic and immunohistochemical study of 50 cases of eccrine mixed tumor, complemented by a literature review. Our study identified some unusual histopathologic features, thus extending the morphologic spectrum of this neoplasm. These included prominent cribriform areas, clear cell change, pseudorosette structures, prominent osseous metaplasia, and physaliphorous-like cells. Most of these features have not been previously recorded in eccrine mixed tumors and may represent a potential diagnostic pitfall.

• MeSH
• dospělí MeSH
• ekrinní žlázy metabolismus   patologie   MeSH
• imunohistochemie metody   MeSH
• lidé středního věku MeSH
• lidé MeSH
• maligní smíšený nádor metabolismus   patologie   MeSH
• mladý dospělý MeSH
• nádorové biomarkery metabolismus   MeSH
• nádory kožních adnex metabolismus   patologie   MeSH
• nádory kůže metabolismus   patologie   MeSH
• nádory potních žláz metabolismus   patologie   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• kazuistiky MeSH
• přehledy MeSH