Q51101506
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29 s. : il., tab. ; 21 cm
- MeSH
- antikonvulziva MeSH
- chronická nemoc MeSH
- epilepsie MeSH
- osteopaté MeSH
- osteopatické lékařství MeSH
- Konspekt
- Patologie. Klinická medicína
- NLK Obory
- patologie
- NLK Publikační typ
- studie
AIMS: While most antiepileptic drugs (AEDs) have been associated with various adverse effects on bone health, for the recently introduced lacosamide (LCM) no corresponding data have been published. The present study evaluates the effect of LCM on bone mineral density, bone turnover markers, and bone mechanical strength in a rat model. METHODS: 16 orchidectomized Wistar rats were divided into control and experimental groups, 8 rats each. Dual energy X-ray absorptiometry was used to measure bone mineral density (BMD). As bone metabolism markers, the concentrations of bone markers were assayed in bone homogenate. In addition, both femurs were measured and used for biomechanical testing. RESULTS: Compared to the control group, we found lower BMD in the experimental group in the area of the left (8%) as well as the right femur (12%), all differences being statistically significant. In both femur diaphyses, but not in lumbar vertebrae, BMD was lower in the LCM group, suggesting a preferential effect on cortical bone. However, neither the thickness of the diaphyseal cortical bone nor the fragility in biomechanical testing was different between the groups. Of the bone metabolism markers, the significant decline was in procollagen type I N-terminal peptide (PINP) levels (37.4%), suggesting a decrease in osteoid synthesis. CONCLUSION: We assume then that long-lasting exposure to LCM can represent a certain risk to the health of bone in the setting of gonadal insufficiency. Further studies will be needed to confirm these findings and to determine how high the risk will be in comparison to the other AEDs.
- MeSH
- absorpční fotometrie MeSH
- acetamidy farmakologie MeSH
- antikonvulziva farmakologie MeSH
- biomechanika MeSH
- epilepsie farmakoterapie metabolismus MeSH
- femur metabolismus MeSH
- kosti a kostní tkáň účinky léků patofyziologie MeSH
- kostní denzita * MeSH
- krysa rodu rattus MeSH
- modely nemocí na zvířatech MeSH
- potkani Wistar MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- MeSH
- absorpční fotometrie MeSH
- antikonvulziva * aplikace a dávkování farmakologie škodlivé účinky terapeutické užití MeSH
- denzitometrie MeSH
- epilepsie * MeSH
- kostní denzita * MeSH
- lidé MeSH
- metabolické nemoci kostí diagnóza etiologie chemicky indukované patofyziologie terapie MeSH
- metabolické vedlejší účinky léčivých látek * aplikace a dávkování farmakologie metabolismus škodlivé účinky MeSH
- nedostatek vitaminu D etiologie farmakoterapie chemicky indukované metabolismus patologie prevence a kontrola MeSH
- nemoci kostí * diagnóza etiologie chemicky indukované metabolismus MeSH
- osteoporóza * MeSH
- prevalence MeSH
- rizikové faktory MeSH
- sluneční záření MeSH
- směrnice pro lékařskou praxi jako téma MeSH
- vápník nedostatek MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- novinové články MeSH
