- MeSH
- Antioxidants MeSH
- Blood Chemical Analysis MeSH
- Potassium Dichromate blood adverse effects toxicity MeSH
- Glutathione analysis drug effects MeSH
- Glutathione Peroxidase analysis drug effects MeSH
- Glutathione Reductase analysis drug effects MeSH
- Poisoning physiopathology MeSH
- Lipid Peroxidation drug effects MeSH
- Pleurotus * MeSH
- Rats, Wistar physiology blood MeSH
- Dietary Supplements adverse effects MeSH
- Chromium Compounds * blood adverse effects toxicity MeSH
- Statistics as Topic MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- MeSH
- Liver enzymology drug effects MeSH
- Kidney enzymology drug effects MeSH
- Models, Animal MeSH
- Oxidative Stress MeSH
- Lipid Peroxidation MeSH
- Rats, Wistar MeSH
- Thioacetamide * administration & dosage pharmacology adverse effects MeSH
- Transaminases blood MeSH
- Check Tag
- Female MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
- MeSH
- Angiotensin II Type 1 Receptor Blockers administration & dosage pharmacology MeSH
- Glutathione Peroxidase analysis drug effects MeSH
- Glutathione Reductase analysis drug effects MeSH
- Angiotensin-Converting Enzyme Inhibitors * administration & dosage pharmacology MeSH
- Liver enzymology metabolism drug effects MeSH
- Brain enzymology metabolism drug effects MeSH
- Nerve Tissue metabolism drug effects MeSH
- Oxidation-Reduction drug effects MeSH
- Lipid Peroxidation drug effects MeSH
- Rats, Wistar MeSH
- Animals MeSH
- Check Tag
- Male MeSH
- Animals MeSH
- Publication type
- Research Support, Non-U.S. Gov't MeSH
Iron is an essential element which, under certain conditions, can have prooxidant and cancerogenic effects. The effect of iron and iron chelators on the activity of selenoenzymes has been studied. Acute experiments in male Wistar rats demonstrated the prooxidant effect of iron on the selenoenzymes thioredoxin reductase (TrxR) and glutathione peroxidase (GPx). These enzymes represent an important part of the antioxidant defense system. Deferiprone (L1) has been shown to abolish the stimulating effect of iron on lipid peroxidation and reduced glutathione (GSH) levels, and also to inhibit the influence of iron on the activity of TrxR and GPx. Similarly, the flavonoid quercetin abolished the influence of iron on the activity of TrxR. The activity of both selenoenzymes has also been shown to be stimulated using L1, naringin (NAR), quercetin (QUE) and myricetin (MYR) in the absence of iron. Further studies including the combination of synthetic and natural compounds (e.g., flavonoids) are being considered for their possible development and clinical use in antioxidant therapies.
- MeSH
- Antioxidants metabolism MeSH
- Iron Chelating Agents chemistry pharmacology MeSH
- Flavanones chemistry pharmacology MeSH
- Flavonoids chemistry pharmacology MeSH
- Glutathione Peroxidase metabolism MeSH
- Liver drug effects enzymology metabolism pathology MeSH
- Rats MeSH
- Oxidative Stress drug effects MeSH
- Rats, Wistar MeSH
- Pyridones chemistry pharmacology MeSH
- Quercetin chemistry pharmacology MeSH
- Thioredoxin-Disulfide Reductase metabolism MeSH
- Iron antagonists & inhibitors pharmacology MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Although the metabolic and toxicological interactions between essential element selenium (Se) and toxic element cadmium (Cd) have been reported for a long time, the experimental studies explored mostly acute, high-dose interactions. Limited data are available regarding the effects of Se-deficiency on toxicokinetics of cadmium, as well as on the levels of key trace elements--copper, zinc, and iron. In the present study, male and female Wistar weanling rats (n = 40/41) were fed either Se-deficient or Se-adequate diet (<0.06 or 0.14 mg Se per kilogram diet, respectively) for 12 weeks, and from week 9 were drinking water containing 0 or 50 mg Cd/l as cadmium chloride. At the end of the 12-week period, trace element concentrations were estimated by AAS. Selenium-deficient rats of both genders showed significantly lower accumulation of cadmium in the liver, compared to Se-adequate rats. Zinc and iron hepatic levels were not affected by Se-deficiency. However, a significant elevation of copper was found in the liver of Se-deficient rats of both genders. Cadmium supplementation increased zinc and decreased iron hepatic level, regardless of Se status and decreased copper concentration in Se-adequate rats. Se-deficiency was also found to influence the effectiveness of cadmium mobilization in male rats.
- MeSH
- Time Factors MeSH
- Cadmium Chloride metabolism pharmacokinetics MeSH
- Diet MeSH
- Cadmium administration & dosage metabolism pharmacokinetics MeSH
- Rats MeSH
- Weaning MeSH
- Rats, Wistar MeSH
- Selenium administration & dosage deficiency metabolism MeSH
- Spectrophotometry, Atomic MeSH
- Trace Elements metabolism pharmacokinetics MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
