Susceptibility to infectious disease is influenced by multiple host genes, most of which are low penetrance QTLs that are difficult to map in humans. Leishmaniasis is a well-studied infectious disease with a variety of symptoms and well-defined immunological features. Mouse models of this disease have revealed more than 20 QTLs as being susceptibility genes, studies of which have made important contributions to our understanding of the host response to infection. The functional effects of individual QTLs differ widely, indicating a networked regulation of these effects. Several of these QTLs probably also influence susceptibility to other infections, indicating that their characterization will contribute to our understanding of susceptibility to infectious disease in general.

Institute of Molecular Genetics Academy of Sciences of the Czech Republic Fleming nám 2 166 37 Prague Czech Republic

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Improving reproducibility and translational potential of mouse models: lessons from studying leishmaniasis

Effects of Leishmania major infection on the gut microbiome of resistant and susceptible mice

Functionally distinct regions of the locus Leishmania major response 15 control IgE or IFNγ level in addition to skin lesions

Gene-Specific Sex Effects on Susceptibility to Infectious Diseases

Novel Loci Controlling Parasite Load in Organs of Mice Infected With Leishmania major, Their Interactions and Sex Influence

Genetic Regulation of Guanylate-Binding Proteins 2b and 5 during Leishmaniasis in Mice

Calcium Ionophore, Calcimycin, Kills Leishmania Promastigotes by Activating Parasite Nitric Oxide Synthase

Gene-specific sex effects on eosinophil infiltration in leishmaniasis

Natural hybrid of Leishmania infantum/L. donovani: development in Phlebotomus tobbi, P. perniciosus and Lutzomyia longipalpis and comparison with non-hybrid strains differing in tissue tropism

Mapping the genes for susceptibility and response to Leishmania tropica in mouse

Mice with different susceptibility to tick-borne encephalitis virus infection show selective neutralizing antibody response and inflammatory reaction in the central nervous system

Genetics of host response to Leishmania tropica in mice - different control of skin pathology, chemokine reaction, and invasion into spleen and liver

Genetic control of resistance to Trypanosoma brucei brucei infection in mice

Leishmania parasite detection and quantification using PCR-ELISA

Distinct genetic control of parasite elimination, dissemination, and disease after Leishmania major infection

Mouse to human comparative genetics reveals a novel immunoglobulin E-controlling locus on Hsa8q12