INTRODUCTION: Recurrent isolated sleep paralysis (RISP) is a rapid eye movement sleep (REM) parasomnia, characterized by the loss of voluntary movements upon sleep onset and/or awakening with preserved consciousness. Evidence suggests microstructural changes of sleep in RISP, although the mechanism of this difference has not been clarified yet. Our research aims to identify potential morphological changes in the brain that can reflect these regulations. MATERIALS AND METHODS: We recruited 10 participants with RISP (8 women; mean age 24.7 years; SD 2.4) and 10 healthy control subjects (w/o RISP; 3 women; mean age 26.3 years; SD 3.7). They underwent video-polysomnography (vPSG) and sleep macrostructure was analyzed. After that participants underwent magnetic resonance imaging (MRI) of the brain. We focused on 2-dimensional measurements of cerebellum, pons and thalamus. Statistical analysis was done in SPSS program. After analysis for normality we performed Mann-Whitney U test to compare our data. RESULTS: We did not find any statistically significant difference in sleep macrostructure between patients with and w/o RISP. No evidence of other sleep disturbances was found. 2-dimensional MRI measurements revealed statistically significant increase in cerebellar vermis height (p = 0.044) and antero-posterior diameter of midbrain-pons junction (p = 0.018) in RISP compared to w/o RISP. DISCUSSION: Our results suggest increase in size of cerebellum and midbrain-pons junction in RISP. This enlargement could be a sign of an over-compensatory mechanism to otherwise dysfunctional regulatory pathways. Further research should be done to measure these differences in time and with closer respect to the frequency of RISP episodes.
- Publikační typ
- časopisecké články MeSH
Sleep is essential component of life. Even though the research in this field develops constantly, there are still many aspects of this rather complex process that remains to be fully clarified. One of these aspects, reason why we actually sleep, is perhaps the most crucial. In this mini review we aim to address this question and discuss potential functions of sleep. Many recent scientific papers are currently available that covers similar topic. We tried to summarize these recent findings. There are certainly many ways how to approach this rather complex issue. Our article will specifically focus on role of sleep in neuronal development, synaptic plasticity, memory consolidation or mental health in general. Its role in immune system functioning will also be mentioned. Moreover, we will also consider more general functions of sleep, such as well-being of the organisms or securing survival of the individual. In conclusion, we will highlight possible main function of sleep.
- MeSH
- duševní zdraví * MeSH
- konsolidace paměti MeSH
- lidé MeSH
- mozek imunologie fyziologie MeSH
- neuroimunomodulace MeSH
- neuroplasticita MeSH
- spánek * MeSH
- zdravotní stav MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Potíže se spánkem patří k častým zdravotním problémům seniorů. Ve věku nad 65 let se typicky setkáváme jednak s primárními poruchami spánku, ale také s poruchami spánku, které vznikají v důsledku komorbidních interních či psychiatrických onemocnění či v souvislosti s jejich léčbou. Cílem tohoto sdělení je popsat fyziologické změny spánku u seniorů, podat přehled nejčastějších poruch spánku a představit současné možnosti léčby.
Sleep issues are common in older patients. In patients aged 65 years and above we generally treat both primary sleep disordersand sleep disturbances that are related to comorbid internal or psychiatric disorders or occur due to medication used. The aimof this paper is to describe physiological changes of sleep in elderly patients, outline the most common sleep disorders in thiscohort along with current treatment options.
- MeSH
- diferenciální diagnóza MeSH
- duševní poruchy MeSH
- komorbidita MeSH
- lidé MeSH
- porucha chování v REM spánku diagnóza terapie MeSH
- poruchy iniciace a udržování spánku etiologie terapie MeSH
- poruchy spánku a bdění * etiologie patologie terapie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- spánek fyziologie MeSH
- syndrom neklidných nohou diagnóza patologie MeSH
- syndromy spánkové apnoe etiologie patofyziologie MeSH
- Check Tag
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Publikační typ
- práce podpořená grantem MeSH
- přehledy MeSH
- Klíčová slova
- erytropoetin, Any-maze,
- MeSH
- bludiště - učení MeSH
- cévní mozková příhoda * MeSH
- endotelin-1 aplikace a dávkování MeSH
- erythropoetin * aplikace a dávkování terapeutické užití MeSH
- kognice klasifikace účinky léků MeSH
- kognitivní poruchy * prevence a kontrola MeSH
- lidé MeSH
- Morrisovo vodní bludiště MeSH
- potkani Wistar MeSH
- prospektivní studie MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- práce podpořená grantem MeSH
