The aim of this article is to present a practical case study demonstrating the implementation of well-being in schools using the GROW coaching method. The focus of the article is on highlighting the critical importance of well-being in the context of the Ministry of Education’s strategy in the Czech Republic. In the first part, the article pro- vides an overview of well-being’s role within educational systems and why it is becoming an essential component of school management and student success. Various theoretical perspectives on the concept of well-being in education are explored, offering a broader understanding of how it can positively influence not only students, but also teachers and the entire school community. In the final section, the article outlines a step-by-step approach to implementing well-being in schools using the structured GROW coaching model, detailing the practical actions involved and how they align with achieving specific well-being goals. This detailed description of the action method demonstrates how the GROW model can be a powerful tool for school leaders to implement sustainable wellbeing practices, ensuring long-term benefits for both students and staff.
The phenomenon of treatment and social rehabilitation of people with addiction is inherently based on the cooperation and collaboration of many disciplines. These are mainly: psychiatry, addictionology, special pedagogy, andragogy, psychology and social work. The knowledge and experience of experts from the above mentioned fields and from the described institutions in the context of cooperation with information technology experts is reflected in the main result of the product discussed in the article. This is the software: a web application for mobile phones and other devices. The Five Ways to Wellbeing method is a powerful tool for promoting mental health and wellbeing that has been developed by the UK NHS. This method focuses on five key areas that can help maintain good mental health and prevent relapse. These are 1. keeping in touch with other people, 2. regular exercise, 3. maintaining mindfulness, 4. learning new things, and 5. altruism. This article presents part of the results of an evaluation study conducted within the framework of the TAČR project ÉTA: Application for the development of social competences of people with addiction in the context of indications for special education and therapeutic intervention, reg. no.: TL05000482. The project is guaranteed by Palacký University in Olomouc. The research was conducted at P-Centrum z.s., non-profit organization focused on addictology services, which is the application guaranty of the project. The aim of the paper is to present how the research implemented the Five Ways to Wellbeing methods into a web-based application for E-health. The methodological design of the study is based on qualitative research, specifically an evaluation study. The results suggest that the Five ways to wellbeing method is suitable for implementation in this web-based application and offers further potential in addiction treatment and relapse prevention.
Mutations can be induced by environmental factors but also arise spontaneously during DNA replication or due to deamination of methylated cytosines at CpG dinucleotides. Sites where mutations occur with higher frequency than would be expected by chance are termed hotspots while sites that contain mutations rarely are termed coldspots. Mutations are permanently scanned and repaired by repair systems. Among them, the mismatch repair targets base pair mismatches, which are discriminated from canonical base pairs by probing altered elasticity of DNA. Using biased molecular dynamics simulations, we investigated the elasticity of coldspots and hotspots motifs detected in human genes associated with inherited disorders, and also of motifs with Czech population hotspots and de novo mutations. Main attention was paid to mutations leading to G/T and A+/C pairs. We observed that hotspots without CpG/CpHpG sequences are less flexible than coldspots, which indicates that flexible sequences are more effectively repaired. In contrary, hotspots with CpG/CpHpG sequences exhibited increased flexibility as coldspots. Their mutability is more likely related to spontaneous deamination of methylated cytosines leading to C > T mutations, which are primarily targeted by base excision repair. We corroborated conclusions based on computer simulations by measuring melting curves of hotspots and coldspots containing G/T mismatch.
- MeSH
- CpG ostrůvky MeSH
- DNA chemie genetika MeSH
- lidé MeSH
- mutace * MeSH
- nukleotidové motivy * MeSH
- simulace molekulární dynamiky * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
Mutations in human genes can be responsible for inherited genetic disorders and cancer. Mutations can arise due to environmental factors or spontaneously. It has been shown that certain DNA sequences are more prone to mutate. These sites are termed hotspots and exhibit a higher mutation frequency than expected by chance. In contrast, DNA sequences with lower mutation frequencies than expected by chance are termed coldspots. Mutation hotspots are usually derived from a mutation spectrum, which reflects particular population where an effect of a common ancestor plays a role. To detect coldspots/hotspots unaffected by population bias, we analysed the presence of germline mutations obtained from HGMD database in the 5-nucleotide segments repeatedly occurring in genes associated with common inherited disorders, in particular, the PAH, LDLR, CFTR, F8, and F9 genes. Statistically significant sequences (mutational motifs) rarely associated with mutations (coldspots) and frequently associated with mutations (hotspots) exhibited characteristic sequence patterns, e.g. coldspots contained purine tract while hotspots showed alternating purine-pyrimidine bases, often with the presence of CpG dinucleotide. Using molecular dynamics simulations and free energy calculations, we analysed the global bending properties of two selected coldspots and two hotspots with a G/T mismatch. We observed that the coldspots were inherently more flexible than the hotspots. We assume that this property might be critical for effective mismatch repair as DNA with a mutation recognized by MutSα protein is noticeably bent.
- MeSH
- DNA chemie genetika MeSH
- faktor VIII genetika MeSH
- genetická predispozice k nemoci MeSH
- konformace nukleové kyseliny MeSH
- LDL-receptory genetika MeSH
- lidé MeSH
- molekulární modely MeSH
- nukleotidové motivy MeSH
- protein CFTR genetika MeSH
- simulace molekulární dynamiky MeSH
- zárodečné mutace * MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- Klíčová slova
- etopedie,
- MeSH
- chování mladistvých psychologie MeSH
- dítě MeSH
- lidé MeSH
- mladiství MeSH
- pedagogická psychologie MeSH
- poruchy chování u dětí * diagnóza prevence a kontrola terapie MeSH
- poruchy sociálního chování * diagnóza prevence a kontrola terapie MeSH
- sociální psychologie MeSH
- výzkum MeSH
- Check Tag
- dítě MeSH
- lidé MeSH
- mladiství MeSH
Affiliation: Research on quality of life for individuals with special needs: SPP: 43413041/31. Institute of special education studies, Faculty of Education, Palacky University, Olomouc, Czech Republic. Abstract: The following text aims to fulfil two purposes; the first purpose being to create a theoretical outline of aftercare. The second purpose comprises of presenting and comparing research regarding the explored subject. Most of the research presented in the paper was undertaken at the Institute of Special Education Studies at the Palacky University’s Faculty of Education. The results of three diploma theses supervised by the author of this text are also used.
- Klíčová slova
- prevence relapsu,
- MeSH
- alkoholismus MeSH
- bydlení klasifikace trendy MeSH
- kvalita života MeSH
- lidé MeSH
- mezioborová komunikace MeSH
- následná péče * metody organizace a řízení pracovní síly MeSH
- péče orientovaná na pacienta MeSH
- poruchy spojené s užíváním psychoaktivních látek MeSH
- práva pacientů MeSH
- sociální péče MeSH
- sociální práce MeSH
- speciální vzdělávání MeSH
- učební obory metody MeSH
- výzkum * MeSH
- vzdělávání pacientů jako téma MeSH
- zaměstnanost MeSH
- závislost (psychologie) * MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Česká republika MeSH
- Klíčová slova
- dlouhodobě abstinující, doléčovací programy,
- MeSH
- dospělí MeSH
- kognitivně behaviorální terapie MeSH
- lidé MeSH
- párová terapie metody MeSH
- poruchy spojené s užíváním psychoaktivních látek * psychologie rehabilitace MeSH
- střídmost * MeSH
- vyjednávání * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- Publikační typ
- kazuistiky MeSH
Cílem příspěvku je informovat čtenáře o novém postupu ambulantní práce s lidmi závislými na stimulačních drogách (kokain, crack, pervitin). Nová metodika práce s názvem Krátký intervenční program je využívána ve Velké Británii. V rámci spolupráce s britskou společností Rugby House, která je garantem zmíněné metodiky, bude program přepracován pro uživatele pervitinu, následně bude v průběhu tří let vyhodnocována jeho úspěšnost. Výsledkem práce bude nová metodika s názvem Krátký intervenční program pro uživatele pervitinu.
The goal of this report is to provide information about a new approach to the outpatient treatment of people addicted to stimulant drugs such as cocaine, crack, and pervitin. A new approach involving a brief intervention programme has been implemented in the UK. This methodology was developed by Aidan Gray of Rugby House, London. On the basis of cooperation between P-centrum Olomouc and Rugby House London, we would like to use this methodology in the Czech Republic. The programme was primarily designed for persons addicted to cocaine and crack. We intend to adapt it for users of pervitin in the Czech Republic. During a three-year period we will evaluate the programme to ascertain its effectiveness. The outcome of our work will be the Pervitin Use Brief Intervention Programme. The article describes the experience of pervitin users only. Therefore, it is not possible to generalise all the information presented in this article or apply it to the drug user population as a whole.
