Biocompatibility is one of the key issues for implants, especially in the case of stainless steel with medium to low biocompatibility, which may lead to a lack of osseointegration and consequently to implant failure or rejection. To precisely control preferential cell growth sites and, consequently, the biocompatibility of prosthetic devices, two types of surfaces were analyzed, containing periodic nanogrooves laser induced periodic surface structure (LIPSS) and square-shaped micropillars. For the fast and efficient production of these surfaces, the unique combination of high energy ultrashort pulsed laser system with multi-beam and beamshaping technology was applied, resulting in increased productivity by 526% for micropillars and 14 570% for LIPSS compared to single beam methods.In vitroanalysis revealed that micro and nanostructured surfaces provide a better environment for cell attachment and proliferation compared to untreated ones, showing an increase of up to 496% in the number of cells compared to the reference. Moreover, the combination of LIPSS and micropillars resulted in a precise cell orientation along the periodic microgroove pattern. The combination of these results demonstrates the possibility of mass production of functionalized implants with control over cell organization and growth. Thus, reducing the risk of implant failure due to low biocompatibility.
V oblasti ezofageálneho hiatu sa môžu vyskytnúť štyri typy hernie. I. typ predstavuje hiátová sklzná hernia. II. typ predstavuje hernia všeobecne známa ako paraezofageálna hernia. Pri tomto type hemie kardia žalúdka a distálny pažerák zostávajú pod hranicou. Oslabeným miestom vo frenoezofageálnej membráne sa fundus žalúdka dostáva do hrudníka nad bránicu. Autori prezentujú 10 pacientov s paraezofageálnou herniou, ktori boli operovaní na II. chirurgickej klinike LF UPJŠ , FN L. Pasteura v Košiciach. Išlo o dospelých pacientov, 5 mužov a 5 žien. U 4 pacientov išlo o tzv. „upside-down stomach". Hernie boli vo všetkých pripadoch operované cestou aparotómie, po repozícii žalúdka do brušnej dutiny bola rekonštruovaná oblasť hiatu a bránice. Jedna pacientka bola operovaná urgentně pre krvácanie z vredu žalúdka. Bezprostredné pooperačné výsledky boli dobré, pooperačný priebeh bol u všetkých pacientov priaznivý, bez komplikácii. Záverom autori uvádzajú, že indikáciou na chirurgický výkon by mala byť každá diagnostikovaná paraezofageálna hernia. Antirefluxná operácia by mala byť uskutočnená pri symptómoch gastroezofageálneho refluxu. Otázka operačného pristupu (torakotómia alebo laparotómia) je stále diskutovaná, každý má svojich zástancov ale v posledných rokoch do popredia sa dostáva laparoskopické riešenie paraezofageálnej hernie.
Four types of hernia may occur in the area of esophageal hiatus. Type I is represented by hiatus slipping hernia. Type II is represented by hernia, which is generally known as paraesophageal hernia. In this type of hernia, cardia and distal stomach remain under diaphragm. The weakened tissue in phreno-esophageal membrane is the place, where stomach fundus penetrates into thorax above the diaphragm. The authors present 10 patients with paraesophageal hernia, who were operated on at the 2nd Surgerv Clinic of Medical Faculty, UPJŠ, Faculty Hospital L. Pasteur in Košice. These were adult patients, five man and five women. In four patients, so called „upside-down stomach" was the case. Hernias were operated on in all cases by laparotomy, after reposition of the stomach into abdominal cavity the area of hiatus and diaphragm was reconstructed. One patient was operated on under emergency conditions for bleeding from stomach ulcer. Immediate postoperation results were good, the postoperation course was favorable in all patients, no complications occurred. In conclusion, the authors are of the opinion that every diagnosed paraesophageal hernia should be indicated for surgical intervention. An anti-reflux operation should be executed in symptoms of gastro-esophageal reflux. The question of operation approach (thoracotomy or laparotomy) is a matter of continuous discussion, each of them having its advocates. However, in recent years laparoscopic solution of paraesophageal hernia is getting increasing attention.
- MeSH
- dospělí MeSH
- gastroezofageální reflux chirurgie MeSH
- hiátová hernie chirurgie klasifikace MeSH
- laparotomie využití MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři MeSH
- torakotomie využití MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- přehledy MeSH
- Publikační typ
- abstrakt z konference MeSH
- MeSH
- antikoagulancia terapeutické užití MeSH
- dospělí MeSH
- heparin nízkomolekulární terapeutické užití MeSH
- lidé MeSH
- tromboflebitida diagnóza terapie MeSH
- trombolytická terapie metody MeSH
- trombóza diagnóza terapie MeSH
- vena subclavia patologie MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
