• Publikační typ
• abstrakt z konference MeSH

BACKGROUND: Atherosclerosis and coronary artery disease (CAD) are a common condition and cause of death in the elderly population. There are difficulties with risk assessment in the elderly as the objectification of their symptomatic status can be challenging due to neuromuscular weakness, physical deconditioning or neurological, orthopaedic, peripheral vascular, or respiratory limitations. Non-invasive coronary artery velocity assessment by Doppler method at rest could be helpful in the elderly population. To evaluate the prognostic role of coronary artery ultrasound assessment in a non-selected elderly population in everyday clinical practice. METHODS: One hundred forty-five patients, aged ≥75years (99 women; 80 ± 4 years), formed the study group. Left coronary artery flows were scanned in addition to conventional echocardiography. During a median follow-up of 26 months, 16 deaths and 2 non-fatal MI occurred. RESULTS: In multivariable analysis, maximal coronary velocity was the only independent predictor for mortality (heart rate [HR]: 1.02, 95%, CI: 1.01-1.04, p < .0005) and for mortality/MI (HR: 1.02, 95%, CI: 1.01-1.03, p < .0001). The value of 110 cm/s maximal coronary flow velocity (CFL) in the proximal segments of left arteries was the best predictor for death, sensitivity 50%, specificity 90%, p < .005. The annual mortality rate was 16.6% persons/year for patients with elevated CFL ≥110 cm/s. The value 81 cm/s was the best predictor for death/MI, sensitivity 61%, specificity 80%, p < .0005; annual mortality rate was 11.2% persons/year for patients with elevated CFL ≥81 cm/s (p < .0001). CONCLUSION: Doppler CFL scanning during routine echocardiography is a feasible and valuable tool for assessment of short-term prognosis in elderly patients.

• MeSH
• dopplerovská echokardiografie * metody   MeSH
• echokardiografie MeSH
• koronární cirkulace fyziologie   MeSH
• lidé MeSH
• nemoci koronárních tepen * MeSH
• prognóza MeSH
• rychlost toku krve fyziologie   MeSH
• senioři MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

Publikácia sa zameriava na mitochondriálne obličkové choroby. Určené odbornej verejnosti.

• MeSH
• mitochondriální nemoci MeSH
• nemoci ledvin MeSH
• Publikační typ
• monografie MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• nefrologie

• Publikační typ
• abstrakt z konference MeSH

BACKGROUND: Prostate cancer (PCa) is the second most commonly diagnosed cancer in men. To date, the role of the combined application of long non-coding RNAs (PCA3, DLX1, HOXC6, TMPRSS2:ERG) for obtaining the most accurate method of detection of PCa has not yet been comprehensively investigated. METHODS: In total 240 persons were included in the retrospective study. Among them were 150 patients with confirmed PCa, 30 patients with benign prostatic hyperplasia, 30 patients with active chronic prostatitis and 30 healthy volunteers. In all patients, the urine samples were collected prior to biopsy or treatment. Polymerase chain reaction with reverse transcription was performed to detect the expression level of PCA3, HOXC6, DLX1 and the presence of the TMPRSS2:ERG transcript. RESULTS: PCA3 was detected in urine samples in all cases. Using a PCA3 score of 56 allowed the differentiation between PCa and all other cases with a sensitivity of 61% and specificity of 96% (p < 0.001) while a PCA3 score threshold value of 50 resulted in a differentiation between clinically significant PCa (ISUP grades 2-5) and all other cases with a sensitivity of 93% and specificity of 93% (p < 0.001). The TMPRSS2:ERG expression in urine was detected exclusively in the group of patients with PCa and only in 16% of all cases. CONCLUSIONS: PCA3 score detected in urine demonstrated moderate sensitivity and good specificity in differentiation between PCa and non-PCa and high sensitivity and specificity in differentiation between clinically significant PCa and non-PCa.

• MeSH
• antigeny nádorové * genetika   MeSH
• fúzní onkogenní proteiny genetika   moč   MeSH
• homeodoménové proteiny genetika   MeSH
• lidé MeSH
• nádorové biomarkery moč   MeSH
• nádory prostaty * diagnóza   genetika   MeSH
• prostata patologie   MeSH
• prostatický specifický antigen MeSH
• retrospektivní studie MeSH
• serinové endopeptidasy genetika   MeSH
• transkripční regulátor ERG MeSH
• Check Tag
• lidé MeSH
• mužské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH

• MeSH
• chronické selhání ledvin dietoterapie   MeSH
• dialýza ledvin MeSH
• nízkoproteinová dieta MeSH
• nutriční terapie MeSH
• průzkumy a dotazníky MeSH
• znalosti MeSH

Metabolic reprogramming of cancer cells is a common hallmark of malignant transformation. The preference for aerobic glycolysis over oxidative phosphorylation in tumors is a well-studied phenomenon known as the Warburg effect. Importantly, metabolic transformation of cancer cells also involves alterations in signaling cascades contributing to lipid metabolism, amino acid flux and synthesis, and utilization of ketone bodies. Also, redox regulation interacts with metabolic reprogramming during malignant transformation. Flavonoids, widely distributed phytochemicals in plants, exert various beneficial effects on human health through modulating molecular cascades altered in the pathological cancer phenotype. Recent evidence has identified numerous flavonoids as modulators of critical components of cancer metabolism and associated pathways interacting with metabolic cascades such as redox balance. Flavonoids affect lipid metabolism by regulating fatty acid synthase, redox balance by modulating nuclear factor-erythroid factor 2-related factor 2 (Nrf2) activity, or amino acid flux and synthesis by phosphoglycerate mutase 1. Here, we discuss recent preclinical evidence evaluating the impact of flavonoids on cancer metabolism, focusing on lipid and amino acid metabolic cascades, redox balance, and ketone bodies.

• MeSH
• aminokyseliny * MeSH
• faktor 2 související s NF-E2 metabolismus   MeSH
• flavonoidy farmakologie   MeSH
• ketolátky metabolismus   MeSH
• lidé MeSH
• metabolismus lipidů MeSH
• nádorová transformace buněk metabolismus   MeSH
• nádory * farmakoterapie   metabolismus   MeSH
• oxidace-redukce MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Publikácia sa zameriava na úlohu mitochondrií v imunite a imunitnom systéme, a na ďalej napríklad na oxidačný stres a koenzýmy. Určené odbornej verejnosti.

• MeSH
• antioxidancia MeSH
• imunita MeSH
• imunitní systém MeSH
• mitochondriální nemoci MeSH
• mitochondrie MeSH
• oxidační stres MeSH
• ubichinon MeSH
• Publikační typ
• monografie MeSH

• Konspekt
• Patologie. Klinická medicína
• NLK Obory
• alergologie a imunologie

BACKGROUND: There is a lack of information about the prognostic value of high velocity in coronary arteries during echocardiography. The present study was aimed at investigating the three-year prognostic value of coronary velocity assessment in all patients who were referred for echocardiography examination. METHODS: The prospective study comprises 747 consecutive patients. Death, myocardial infarction (MI), acute coronary syndrome (ACS), and/or revascularisation were defined as major adverse cardiac events (MACE). Routine echocardiography was added with coronary velocity assessment in the left main, anterior descending, or circumflex coronary arteries by the Doppler method. RESULTS: During a median follow-up of 36 months, 192 patients experienced MACE. Deaths occurred more frequently in patients with high local velocity in proximal left-sided segments vs. in middle left-sided segments vs. patients without high coronary velocity (9 vs. 3 vs. 1%, p < 0.0001). Death/MI/ACS occurred in 17 vs. 7 vs. 1%, p < 0.0001, respectively. Age (HR 1.04, 95% CI 1.00; 1.06; p < 0.04), a velocity more than 65 cm/s in any proximal segments of the arteries (HR 4.7, 95% CI 1.9; 11.9; p < 0.002), ejection fraction (HR 0.97, 95% CI 0.94; 0.99; p < 0.007) were strong independent prognostic predictors of death/MI/ACS. The maximal velocity of coronary flow velocity had a significant additive prognostic value to ejection fraction. CONCLUSIONS: The coronary velocity parameters give long-term prognostic information that can be used to identify persons with a high risk of MACE in consecutive non-selected patients.

• MeSH
• echokardiografie * MeSH
• infarkt myokardu * MeSH
• koronární cévy diagnostické zobrazování   MeSH
• koronární cirkulace MeSH
• lidé MeSH
• prognóza MeSH
• prospektivní studie MeSH
• rychlost toku krve MeSH
• tepový objem MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH

Všeobecné lekárstvo predstavuje odbor primárnej zdravotnej starostlivosti, ktorého fungovanie významne ovplyvňuje poskytovanie zdravotnej starostlivosti ako takej. Zabezpečenie kompetentných všeobecných lekárov si vyžaduje ich kvalitné vzdelávania. Na dosiahnutie tohto cieľa je vhodné začať už počas vysokoškolského pregraduálneho vzdelávania medikov a následne v rámci špecializačného štúdia v špecializačnom odbore všeobecné lekárstvo. Posledné roky vzdelávanie všeobecných lekárov na Slovensku prešlo viacerými pozitívnymi zmenami, ktorých cieľom je doplnenie kvalitných, kompetentných a erudovaných všeobecných lekárov do praxe. K 31. júlu 2022 bolo na Slovenskej zdravotníckej univerzite v Bratislave (SZU) do odboru všeobecné lekárstvo zaradených 433 lekárov, z toho do tzv. klasickej formy 316 a rezidentského štúdia 117 lekárov (z toho 38 malo prerušené špecializačné štúdium z dôvodu materskej alebo rodičovskej dovolenky). V klasickej forme bolo z celkového počtu 316 lekárov 22 zaradených do doplnkovej odbornej prípravy na získanie špecializácie v odbore všeobecné lekárstvo pre lekárov so získanou špecializáciou v odboroch vnútorného lekárstva (DOP-INT) a 25 v odbore anesteziológia a intenzívna medicína (DOP-AIM). Za posledných 10 rokov na SZU absolvovali špecializačné štúdium v špecializačnom odbore všeobecné lekárstvo 375 lekári, z toho 261 v tzv. klasickej forme, vrátane 18 v DOP-INT, traja v DOP-AIM a 114 rezidenti. Nakoľko všeobecné lekárstvo je veľmi dynamickým odborom medicíny, aj vzdelávanie musí reflektovať jeho potreby.

General medicine represents a field of primary health care, the functioning of which significantly affects the provision of subsequent health care as well. Ensuring competent general practitioners requires their quality education. To achieve this goal, it is advisable to start already during the undergraduate medical education and then as part of a specialized study in the specialized field of General Medicine. In recent years, the education of general practitioners in Slovakia has undergone several positive changes, the aim of which is to add high-quality, competent and knowledgeable general practitioners to practice. As of the date 31. 7. 2022, 433 doctors were enrolled in the education of general medicine at Slovak Medical University in Bratislava, (SMU) of which the so-called of the classical form 316 and residency study 117. In the classical form, out of the total number of 316 doctors, 22 were enrolled in additional training to obtain a specialization in the field of general medicine for doctors with a specialization in the field of internal medicine (AT-INT) and 25 in the field of anesthesiology and intensive care medicine (AT-AICM). Over the past 10 years at SMU, 375 doctors have completed specialized studies in the specialized field of general medicine, of which 261 in the so-called classical form, including 18 in AT-INT, 3 in AT-AICM and 114 residents. Since general medicine is a very dynamic field of medicine, education must also reflect its needs.

• MeSH
• kontinuální vzdělávání lékařů * MeSH
• lidé MeSH
• praktické lékařství MeSH
• studium lékařství specializační postgraduální MeSH
• Check Tag
• lidé MeSH
• Geografické názvy
• Slovenská republika MeSH