BACKGROUND: There is no international consensus on an optimal ultrasound score for monitoring of rheumatoid arthritis (RA) on patient-level yet. Our aim was to reassess the US7 score for the identification of the most frequently pathologic and responsive joint/tendon regions, to optimize it and contribute to an international consensus. Furthermore, we aimed to evaluate the impact of disease duration on the performance of the score. METHODS: RA patients were assessed at baseline and after 3 and 6 months of starting/changing DMARD therapy by the US7 score in greyscale (GS) and power Doppler (PD). The frequency of pathologic joint/tendon regions and their responsiveness to therapy were analyzed by Friedman test and Cochrane-Q test respectively, including the comparison of palmar vs. dorsal regions (chi-square test). The responsiveness of different reduced scores and the amount of information retained from the original US7 score were assessed by standardized response means (SRM)/linear regression. Analyses were also performed separately for early and established RA. RESULTS: A total of 435 patients (N = 138 early RA) were included (56.5 (SD 13.1) years old, 8.2 (9.1) years disease duration, 80% female). The dorsal wrist, palmar MCP2, extensor digitorum communis (EDC) and carpi ulnaris (ECU) tendons were most frequently affected by GS/PD synovitis/tenosynovitis (wrist: 45%/43%; MCP2: 35%/28%; EDC: 30%/11% and ECU: 25%/11%) and significantly changed within 6 months of therapy (all p ≤0.003 by GS/PD). The dorsal vs. palmar side of the wrist by GS/PD (p < 0.001) and the palmar side of the finger joints by PD (p < 0.001) were more frequently pathologic. The reduced US7 score (GS/PD: palmar MCP2, dorsal wrist, EDC and ECU, only PD: dorsal MCP2) showed therapy response (SRM 0.433) after 6 months and retained 76% of the full US7 score's information. No major differences between the groups of early and established RA could be detected. CONCLUSIONS: The wrist, MCP2, EDC, and ECU tendons were most frequently pathologic and responsive to therapy in both early and established RA and should therefore be included in a comprehensive score for monitoring RA patients on patient-level.
- MeSH
- lidé MeSH
- mladiství MeSH
- revmatoidní artritida * diagnostické zobrazování farmakoterapie patologie MeSH
- šlachy diagnostické zobrazování MeSH
- stupeň závažnosti nemoci MeSH
- synovitida * patologie MeSH
- ultrasonografie MeSH
- zápěstí MeSH
- zápěstní kloub diagnostické zobrazování patologie MeSH
- Check Tag
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- pozorovací studie MeSH
Vojtova metoda je jednotný systém včasné neurokineziologické diagnostiky a včasné terapie mozkových hybných poruch reflexní lokomocí. Pokud je tento systém uplatněn u symptomaticky rizikových dětí již v prvním trimenonu prvního roku života, má významný vliv na kvalitu života těchto dětí. V článku je podán jednoduchý přehled vyšetření, který umožní včasnou diagnostiku ohrožení vývojem dětské mozkové obrny (DMO)(1).
Vojta´s method constitutes an integrated system of early neurokinesiologic diagnostics and early therapy of locomotory disorders through reflex locomotion. As long as this sytem is applied to symptomatically at risk children already in the first trimestr of their life, it can significantly improve the quality of their life. The paper outlines the examination that makes possible early diagnostics of possible threat by the development of cerebral palsy.
- Klíčová slova
- Vojtova metoda, dětská mozková obrna, symptomaticky rizikové dítě,
- MeSH
- časná diagnóza MeSH
- kojenec MeSH
- kvalita života MeSH
- lidé MeSH
- mozková obrna diagnóza etiologie prevence a kontrola MeSH
- pohybové poruchy diagnóza etiologie MeSH
- reflexní terapie metody využití MeSH
- vývojové poruchy u dětí diagnóza etiologie MeSH
- Check Tag
- kojenec MeSH
- lidé MeSH
- Publikační typ
- přehledy MeSH
OBJECTIVE: To estimate the annual incidence and prevalence of psoriatic arthritis (PsA), ankylosing spondylitis (AS), and reactive arthritis (ReA) in a sample of the Czech population. METHODS: The population-based study was conducted in two regions of the Czech Republic (with a total population of 186000 inhabitants) in 2002-2003. Incident cases were registered on condition of confirming a definite diagnosis according to existing classification criteria during the study period (1 March 2002 to 1 March 2003). Prevalence was studied on the basis of identification of established diagnoses (before 1 March 2002) from registers of living patients of participating rheumatologists and other specialists. The age-standardized estimates of incidence and prevalence were calculated using the European standard population. RESULTS: The total annual incidence of PsA in adults aged >or= 16 years was 3.6/100000 [95% confidence interval (CI) 1.4-7.6/100000] and the prevalence of PsA was 49.1/100000 (95% CI 39.5-60.4/100000). The annual incidence of AS in adults was 6.4/100000 (95% CI 3.3-11.3/100000) and the prevalence of AS was 94.2/100000 (95% CI 80.8-109.2/100 000). The annual incidence of ReA in adults was 9.3/100000 (95% CI 5.5-14.8/100000) and the prevalence of ReA was 91.3/100000 (95% CI 78.1-106.2/100000). CONCLUSION: The annual incidence and prevalence rates of PsA, AS, and ReA in the first population-based survey in the Czech Republic compared well with data reported from other countries.
- MeSH
- ankylózující spondylitida epidemiologie MeSH
- dospělí MeSH
- incidence MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- prevalence MeSH
- psoriatická artritida epidemiologie MeSH
- reaktivní artritida epidemiologie MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- věkové rozložení MeSH
- zdravotnické přehledy MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Geografické názvy
- Česká republika MeSH
- MeSH
- epidemiologické studie MeSH
- incidence MeSH
- lidé MeSH
- prevalence MeSH
- revmatické nemoci epidemiologie MeSH
- Check Tag
- lidé MeSH
- Geografické názvy
- Česká republika MeSH
