This article is focused on reviewing the benefit and limitations of utilization of doxorubicin, which is one of the most widely used anticancer drug even though it causes severe side effects. The mechanism of action of common cytostatic drugs is described and special attention is paid to doxorubicin. Its pathway through the body is highlighted and its toxicity is emphasized. Finally, strategy of elimination of the negative effects induced by doxorubicin therapy is mentioned and the most widely approach – the use of liposomes – is summarized.

• Klíčová slova
• stealth, enkapsulace,
• MeSH
• cytostatické látky farmakokinetika   farmakologie   škodlivé účinky   MeSH
• doxorubicin * farmakokinetika   farmakologie   škodlivé účinky   MeSH
• lidé MeSH
• liposomy metabolismus   MeSH
• nádory farmakoterapie   MeSH
• nemoci jater etiologie   MeSH
• nemoci srdce chemicky indukované   MeSH
• nežádoucí účinky léčiv * prevence a kontrola   MeSH
• polyethylenglykoly MeSH
• systémy cílené aplikace léků * metody   MeSH
• zvířata MeSH
• Check Tag
• lidé MeSH
• zvířata MeSH
• Publikační typ
• práce podpořená grantem MeSH
• přehledy MeSH

Carbon nanomaterials, including fullerenes, exhibit not only unique structure and electronic properties but also a significant potential to serve as radical scavengers and/or anti-oxidants. Their conjugation with anticancer drugs such as doxorubicin (DOX) may help to balance severe negative side effects of these cytostatics and also improve the delivery of the drug taking advantage of the enhanced cellular uptake, selectivity to cancer cells, and pH regulated release. In this study, the fullerene (C60) surface was oxidized by concentrated nitric acid, which enabled simple DOX-fullerene conjugation based on π-π stacking and hydrophilic interactions with carboxylic groups. The strength of this noncovalent binding is pH dependent. At a low pH, the amino group of DOX is protonated, however at a higher pH, the amino group is deprotonated, resulting in stronger hydrophobic interactions with the fullerene walls. CE and HPLC were employed for characterization of resulting complexes. The cell toxicity of the conjugates was evaluated using Staphylococcus aureus and finally they were administered into the chicken embryo to assess the applicability for in vivo imaging.

• MeSH
• antibakteriální látky chemie   farmakokinetika   farmakologie   MeSH
• doxorubicin chemie   farmakokinetika   farmakologie   MeSH
• fluorescenční spektrometrie MeSH
• fullereny chemie   farmakokinetika   MeSH
• hydrofobní a hydrofilní interakce MeSH
• kuřecí embryo MeSH
• nosiče léků chemie   farmakokinetika   MeSH
• Staphylococcus aureus účinky léků   MeSH
• tkáňová distribuce MeSH
• zvířata MeSH
• Check Tag
• kuřecí embryo MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

• MeSH
• léčivé přípravky MeSH
• léčivé rostliny MeSH
• ovoce MeSH
• rostlinné extrakty MeSH
• zelenina MeSH

• Konspekt
• Lékařské vědy. Lékařství
• NLK Obory
• farmacie a farmakologie
• nutriční terapie, dietoterapie a výživa

• MeSH
• dítě MeSH
• lidé MeSH
• myokard patologie   MeSH
• prenatální diagnóza MeSH
• srdce MeSH
• Check Tag
• dítě MeSH
• lidé MeSH

• MeSH
• hepatitida B prevence a kontrola   MeSH
• vakcinace MeSH

• MeSH
• lázně MeSH
• nemocnice soukromé MeSH
• rehabilitace metody   MeSH
• tradiční čínská medicína MeSH
• Geografické názvy
• Česká republika MeSH