- MeSH
- dystokie * MeSH
- epiziotomie MeSH
- komplikace porodu MeSH
- lidé MeSH
- poporodní paréza brachiálního plexu epidemiologie etiologie MeSH
- porodní asistentky MeSH
- porodní poranění novorozence epidemiologie etiologie MeSH
- role odborníka MeSH
- těhotenství MeSH
- vedení porodu metody MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
AIMS: Islet cell autoantibodies are associated with autoimmune insulitis and belong to the diagnostic criteria of type 1 diabetes mellitus. However, growing evidence suggests that autoantibodies are present in other types of diabetes. Here, we focus on the autoantibody incidence in Czech patients with maturity-onset diabetes of the young and analyse their functional relevance in terms of diabetes onset and control. METHODS: Autoantibodies against glutamic acid decarboxylase (GAD) 65 and protein tyrosine phosphatase islet antigen 2 (IA-2) were measured in a cohort of 28 Czech patients with maturity-onset diabetes of the young, all confirmed by genetic testing. Selected clinical data were correlated to the status and kinetics of autoantibodies. RESULTS: One quarter of patients with maturity-onset diabetes of the young examined (7/28; 25%) was positive for GAD or IA-2 autoantibodies. GAD autoantibodies were more prevalent (7/7) than IA-2 autoantibodies (1/7). The incidence of autoantibodies did not correlate with human leukocyte antigen status. The patients who were positive for the autoantibodies developed diabetes later than those who were autoantibody-negative, but had worse glycaemic control (increased HbA1c ). Expression of autoantibodies decreased with any improvement of diabetes compensation. Only one patient did not correspond to the above and displayed signs of combined signs of maturity-onset diabetes of the young and Type 1 diabetes. CONCLUSIONS: The data suggest transient but highly prevalent islet cell autoantibody expression in Czech patients with maturity-onset diabetes of the young. The autoantibodies were found in patients with delayed diabetes onset, and in times of insufficient diabetes control. As improvement of glycaemic control was associated with a decrease in levels of autoantibodies, their presence may reflect the kinetics of β-cell destruction induced by causes other than autoimmune ones.
- MeSH
- autoprotilátky imunologie MeSH
- diabetes mellitus 2. typu epidemiologie imunologie metabolismus MeSH
- dítě MeSH
- dospělí MeSH
- glukokinasa genetika MeSH
- glutamát dekarboxyláza imunologie MeSH
- glykovaný hemoglobin metabolismus MeSH
- hepatocytární jaderný faktor 1-alfa genetika MeSH
- hepatocytární jaderný faktor 4 genetika MeSH
- kohortové studie MeSH
- Langerhansovy ostrůvky imunologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- tyrosinfosfatasy receptorového typu, třída 8 imunologie MeSH
- věk při počátku nemoci MeSH
- Check Tag
- dítě MeSH
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
We report about preconceptional and periconceptional care and pregnancy at a woman with JIA. There is necessity to make optimal medical situation before pregnancy (with the aim of long-term remission). This is a common field for activities of physician, gynaecologist and clinical geneticist. The diagnosis was established according to ILAR criteria.
- MeSH
- juvenilní artritida MeSH
- komplikace těhotenství MeSH
- lidé MeSH
- péče před početím MeSH
- perinatální péče MeSH
- těhotenství MeSH
- uveitida MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
- Publikační typ
- kazuistiky MeSH
- MeSH
- alfa-fetoproteiny krev MeSH
- Downův syndrom diagnóza MeSH
- genetické testování analýza MeSH
- komplikace těhotenství MeSH
- lidé MeSH
- maternofetální výměna látek genetika MeSH
- prenatální diagnóza MeSH
- radioimunoanalýza metody MeSH
- těhotenství MeSH
- Check Tag
- lidé MeSH
- těhotenství MeSH
- ženské pohlaví MeSH
