Adipose tissue is now described as an endocrine organ secreting a number of adipokines contributing to the development of inflammation and metabolic imbalance, but also endothelial dysfunction, vascular remodeling, atherosclerosis, and ischemic stroke. Leptin, adiponectin, and resistin are the most studied adipokines which play important roles in the regulation of cardiovascular homeostasis. Leptin and adiponectin mediate both proatherogenic and antiatherogenic responses. Leptin and adiponectin have been linked to the development of coronary heart disease and may be involved in the underlying biological mechanism of ischemic stroke. Resistin, a pro-inflammatory cytokine, is predictive of atherosclerosis and poor clinical outcomes in patients with coronary artery disease and ischemic stroke. The changes in serum levels of novel adipokines apelin, visfatin are also associated with acute ischemic stroke. These adipokines have been proposed as potential prognostic biomarkers of cardiovascular mortality/morbidity and therapeutic targets in patients with cardiometabolic diseases. In this article, we summarize the biologic role of the adipokines and discuss the link between dysfunctional adipose tissue and metabolic/inflammation imbalance, consequently endothelial damage, progression of atherosclerotic disease, and the occurrence of ischemic stroke.
- MeSH
- adipokiny metabolismus MeSH
- ateroskleróza metabolismus MeSH
- cévní mozková příhoda metabolismus MeSH
- ischemie metabolismus MeSH
- lidé MeSH
- nemoci cév metabolismus MeSH
- nemoci nervového systému metabolismus MeSH
- tuková tkáň metabolismus MeSH
- zánět metabolismus MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- přehledy MeSH
Despite the rising trend of cancer disease incidence more and more patients succeed in their fight with the disease. Innovative drugs bring cures or at least improvements to the patient's quality of life. Extensive application of anticancer therapy however brings about the increase of adverse effects of the therapy. Toxic damage of the myocardium remains one of the severest organ damage types with life-threatening consequences. In the last decade, in addition to the known cardio toxicity of traditional cytostatics, specialists have more and more often been facing cardio toxicity caused by targeted oncology therapies. As myocardium damage is hard to treat when the stage of clinical symptoms is reached, emphasis is laid on the timely diagnosing of this drug-related damage. Diagnostic procedures have been introduced for early detection of risk patients before the therapy has even commenced. Timely diagnosis of myocardium effects in the course of the conservative cancer therapy allows for adjustment of the oncology therapy and lifestyle and timely commencement of treatment of the affected myocardium. Echocardiograph is considered the basic procedure of patient monitoring during cancer therapy. MRI of the myocardium and CT cardiograph are limited by price and availability despite their uncontentious role in oncocardiology. Radionuclide ventriculography is considered the gold standard of assessment of the left ventricle function. It is well reproducible and widely available in oncology centres. Laboratory diagnostics of toxic damage of the myocardium focuses on cardinal troponins and natriuretic peptides. This examination performance in clinical practice is undemanding and its application in oncology practice increases.
- MeSH
- 3-jodobenzylguanidin MeSH
- antracykliny klasifikace škodlivé účinky MeSH
- bevacizumab škodlivé účinky MeSH
- biologická terapie škodlivé účinky MeSH
- cílená molekulární terapie klasifikace škodlivé účinky MeSH
- echokardiografie metody MeSH
- elektrokardiografie metody MeSH
- fluoruracil škodlivé účinky MeSH
- jednofotonová emisní výpočetní tomografie metody MeSH
- kardiotoxicita * diagnóza etiologie klasifikace MeSH
- lidé MeSH
- magnetická rezonanční tomografie MeSH
- myokard patologie MeSH
- nádory farmakoterapie komplikace MeSH
- nemoci srdce diagnostické zobrazování diagnóza chemicky indukované MeSH
- protinádorové látky * klasifikace škodlivé účinky MeSH
- radioisotopová ventrikulografie metody MeSH
- rizikové faktory MeSH
- sunitinib škodlivé účinky MeSH
- trastuzumab škodlivé účinky MeSH
- Check Tag
- lidé MeSH
