- MeSH
- Azepines isolation & purification blood urine MeSH
- Benzodiazepines isolation & purification blood urine MeSH
- Chromatography, Gas methods instrumentation MeSH
- Ethanol isolation & purification blood MeSH
- Flunitrazepam isolation & purification blood urine MeSH
- Gastrointestinal Contents chemistry drug effects MeSH
- Mass Spectrometry methods instrumentation MeSH
- Humans MeSH
- Aged MeSH
- Forensic Toxicology methods MeSH
- Drowning MeSH
- Check Tag
- Humans MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
- Keywords
- liguid-liguid extrakce, kyselá hydrolýza, LC-MS/MS,
- MeSH
- Benzodiazepines isolation & purification urine MeSH
- Biotransformation physiology drug effects MeSH
- Chemistry Techniques, Analytical methods MeSH
- Chromatography, Liquid MeSH
- Hydrolysis drug effects MeSH
- Humans MeSH
- Mass Screening MeSH
- Statistics as Topic MeSH
- Tandem Mass Spectrometry MeSH
- Check Tag
- Humans MeSH
Dvacetiletá žena byla nalezena mrtvá ve svém pokoji. Byla medikamentózně léčena pro depresivní a panické poruchy, a opakovaně se pokoušela o suicidium. V blízkosti těla bylo nalezeno mnoho balení předepsaných léčiv, včetně paroxetinu. Při pitvě byly plíce edematózní. Orgány vykazovaly známky mírné kongesce a změny způsobené rozkladem. Autolýzou způsobená ruptura, označená jako gastromalacie, byla popsána na přední části stěny žaludku v oblasti kardie. Toxikologické vyšetření stanovilo 0,78, 3,20 a 17,63 µg/ml paroxetinu v kardiální, respektive femorální krvi a v moči. Acetaminophen a phenobarbital byly také stanoveny, a to v terapeutické či subletální koncentraci. Autoři vyhodnotili údaje získané post mortem, při čemž vzali v úvahu posmrtnou difuzi léků a došli k závěru, že smrt byla způsobena toxicitou paroxetinu spolu se serotoninovým syndromem.
A female in her twenties was found dead in her room. She had received medications for depression and panic disorder, and had attempted suicide several times. Many packets of prescribed drugs, including paroxetine, were found near the corpse. At autopsy, the lungs were edematous. The organs were slightly congested with putrefactive change. Autolytic rupture, considered as gastromalasia, was observed in the anterior cardiac portion of stomach wall. Toxicological examination revealed 0.78, 3.20 and 17.63 µg/ml of paroxetine in the heart blood, femoral blood and urine, respectively. Acetaminophen and phenobarbital were also identified within therapeutic or sub-lethal levels. Taking into consideration postmortem diffusion of drugs, we evaluated postmortem data and concluded that the death was mainly due to toxicity of paroxetine with serotonin syndrome.
- MeSH
- Benzodiazepines isolation & purification toxicity MeSH
- Humans MeSH
- Young Adult MeSH
- Drug-Related Side Effects and Adverse Reactions MeSH
- Poisoning diagnosis etiology pathology MeSH
- Acetaminophen isolation & purification toxicity MeSH
- Paroxetine isolation & purification toxicity MeSH
- Autopsy methods MeSH
- Postmortem Changes MeSH
- Selective Serotonin Reuptake Inhibitors isolation & purification toxicity MeSH
- Serotonin Syndrome diagnosis MeSH
- Forensic Pathology MeSH
- Check Tag
- Humans MeSH
- Young Adult MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
