- MeSH
- Homocysteine administration & dosage metabolism drug effects MeSH
- Homocystinuria * diagnosis diet therapy metabolism physiopathology MeSH
- Humans MeSH
- Methionine administration & dosage metabolism standards MeSH
- Adolescent MeSH
- Diet, Protein-Restricted standards MeSH
- Pyridoxine administration & dosage MeSH
- Amino Acid Metabolism, Inborn Errors MeSH
- Check Tag
- Humans MeSH
- Adolescent MeSH
- Female MeSH
- Publication type
- Case Reports MeSH
BACKGROUND AND AIMS: Adefovir, an acyclic nucleotide reverse transcriptase inhibitor used to treat hepatitis B viral infection, is primarily eliminated renally through cooperation of glomerular filtration with active tubular transport. Nonalcoholic steatohepatitis is a variable in drug disposition, yet the impact on renal transport processes has yet to be fully understood. The goal of this study was to determine the effect of nonalcoholic steatohepatitis on the pharmacokinetics of adefovir in rats given a control or methionine and choline deficient diet to induce nonalcoholic steatohepatitis. METHODS: Animals received a bolus dose of 7mg/kg (35μCi/kg) [(3)H] adefovir with consequent measurement of plasma and urine concentrations. Inulin clearance was used to determine glomerular filtration rate. RESULTS: Methionine and choline deficient diet-induced nonalcoholic steatohepatitis prolonged the elimination half-life of adefovir. This observation occurred in conjunction with reduced distribution volume and hepatic levels of adefovir. Notably, despite these changes, renal clearance and overall clearance were not changed, despite markedly reduced glomerular filtration rate in nonalcoholic steatohepatitis. Alteration of glomerular filtration rate was fully compensated for by a significant increase in tubular secretion of adefovir. Analysis of renal transporters confirmed transcriptional up-regulation of Mrp4, the major transporter for adefovir tubular secretion. CONCLUSIONS: This study demonstrates changes to glomerular filtration and tubular secretion that alter pharmacokinetics of adefovir in nonalcoholic steatohepatitis. Nonalcoholic steatohepatitis-induced changes in renal drug elimination processes could have major implications in variable drug response and the potential for toxicity.
- MeSH
- Adenine analogs & derivatives pharmacokinetics MeSH
- Choline administration & dosage MeSH
- Diet MeSH
- Glomerular Filtration Rate MeSH
- Reverse Transcriptase Inhibitors pharmacokinetics MeSH
- Rats MeSH
- Kidney drug effects metabolism MeSH
- Methionine administration & dosage MeSH
- Non-alcoholic Fatty Liver Disease metabolism MeSH
- Organophosphonates pharmacokinetics MeSH
- Rats, Sprague-Dawley MeSH
- Animals MeSH
- Check Tag
- Rats MeSH
- Male MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
Lékárny jsou velmi často prvním zdravotnickým zařízením, kde si pacienti postěžují na zvýšené vypadávání vlasů. Zde by mělo být pacientovi poskytnuto kvalifikované poradenství ohledně volně prodejných přípravků pro lokální i celkovou doplňkovou terapii. Lékárník nebo asistent by měl zvládnout rozlišit, zda pacientovy potíže je možné zvládnout samoléčbou či pacienta odeslat k lékaři. Článek stručně popisuje typy alopecií a jejich možné příčiny. Podrobněji se zabývá volně prodejnými přípravky pro léčbu vypadávání vlasů, jejich správným použitím a působením. Uveden je praktický souhrn volně dostupných přípravků pro léčbu vypadávání vlasů.
Pharmacies are often the first heath care facility, where pations complain about increased hair loss. There should be provided a qualified patient counselling on OTC products for the local and total additive therapy. Pharmacist or his assistant should manage to distinguish whether the patien's problems can be handled by self-treatment or the patient should be sent to the doctor. This article briefly describes the types of alopecia and their possible causes. In detail occupies with effective agentsfor hair loss treatment and their characteristics. Listed is a practical summ ary of the free available products for the treatment of hair loss.
- Keywords
- vypadávání vlasů,
- MeSH
- Alopecia * drug therapy classification prevention & control MeSH
- Biotin therapeutic use MeSH
- Nonprescription Drugs * classification therapeutic use MeSH
- Humans MeSH
- Methionine administration & dosage therapeutic use MeSH
- Minoxidil administration & dosage therapeutic use MeSH
- Prostaglandins F, Synthetic therapeutic use MeSH
- Hair pathology drug effects MeSH
- Zinc pharmacology therapeutic use MeSH
- Check Tag
- Humans MeSH
- Keywords
- Erdomed,
- MeSH
- Diagnostic Techniques and Procedures MeSH
- Expectorants administration & dosage pharmacology MeSH
- Respiratory Tract Infections diagnosis etiology MeSH
- Cough etiology drug therapy MeSH
- Humans MeSH
- Methionine analogs & derivatives administration & dosage pharmacology MeSH
- Check Tag
- Humans MeSH
Závěrečná zpráva o řešení grantu Interní grantové agentury MZ ČR
Přeruš. str. : il., tab., grafy ; 32 cm + 2 vol. přílohy
V projektu budeme studovat genetické příčiny mírné hyperhomocysteinemie u českých pacientů s atherosklerosou pomocí epidemiologických a molekulárně biologických metod Cílem studie je nalézt mutace odpovědné za hypercysteinemii a rozvoj atherosklerosy a zlepšit diagnosu, léčbu a prevenci této poruchy v naší populaci.; Genetic causes of mild hyperhomocysteinemia in Czech patients with atherosclerosis will be studied by epidemiological, molecular and linkage methods. The aim of the study is to find mutations responsible for hyperhomocysteinemia and atherosclerosis development and to improve diagnosis, treatment and prevention of thiscondition in our population.
- MeSH
- Arteriosclerosis genetics MeSH
- Homocysteine metabolism blood MeSH
- Hyperlipidemias MeSH
- Methionine metabolism administration & dosage MeSH
- Conspectus
- Lékařské vědy. Lékařství
- NML Fields
- angiologie
- vnitřní lékařství
- NML Publication type
- závěrečné zprávy o řešení grantu IGA MZ ČR
