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Potrombotický syndrom je častou komplikací po prodělání hluboké žilní trombózy. Venoprotektivum Detralex pozitivně ovlivňuje nejen subjektivní potíže pacientů, ale i jejich ultrazvukový sonografický nález.

Klíčová slova
DETRALEX, potrombotický syndrom,
MeSH
antikoagulancia terapeutické užití MeSH
bérec krevní zásobení patofyziologie MeSH
chlazení MeSH
diosmin terapeutické užití MeSH
hesperidin MeSH
kompresní obvazy MeSH
lidé středního věku MeSH
lidé MeSH
warfarin terapeutické užití MeSH
žilní insuficience * diagnóza farmakoterapie terapie MeSH
žilní trombóza * diagnóza komplikace terapie MeSH
Check Tag
lidé středního věku MeSH
lidé MeSH
ženské pohlaví MeSH
Publikační typ
kazuistiky MeSH

Článek

BioNano genome mapping of individual chromosomes supports physical mapping and sequence assembly in complex plant genomes

Plant biotechnology journal. 2016 ; 14 (7) : 1523-31. [pub] 20160123

Plant Biotechnol J
ISSN 1467-7652
Medvik
Zdroj

The assembly of a reference genome sequence of bread wheat is challenging due to its specific features such as the genome size of 17 Gbp, polyploid nature and prevalence of repetitive sequences. BAC-by-BAC sequencing based on chromosomal physical maps, adopted by the International Wheat Genome Sequencing Consortium as the key strategy, reduces problems caused by the genome complexity and polyploidy, but the repeat content still hampers the sequence assembly. Availability of a high-resolution genomic map to guide sequence scaffolding and validate physical map and sequence assemblies would be highly beneficial to obtaining an accurate and complete genome sequence. Here, we chose the short arm of chromosome 7D (7DS) as a model to demonstrate for the first time that it is possible to couple chromosome flow sorting with genome mapping in nanochannel arrays and create a de novo genome map of a wheat chromosome. We constructed a high-resolution chromosome map composed of 371 contigs with an N50 of 1.3 Mb. Long DNA molecules achieved by our approach facilitated chromosome-scale analysis of repetitive sequences and revealed a ~800-kb array of tandem repeats intractable to current DNA sequencing technologies. Anchoring 7DS sequence assemblies obtained by clone-by-clone sequencing to the 7DS genome map provided a valuable tool to improve the BAC-contig physical map and validate sequence assembly on a chromosome-arm scale. Our results indicate that creating genome maps for the whole wheat genome in a chromosome-by-chromosome manner is feasible and that they will be an affordable tool to support the production of improved pseudomolecules.

Článek

Chromosomal genomics facilitates fine mapping of a Russian wheat aphid resistance gene

Theoretical and Applied Genetics. 2015 ; 128 (7) : 1373-83. [pub] 20150411

Theor Appl Genet
ISSN 1432-2242
Medvik
Zdroj

KEY MESSAGE: Making use of wheat chromosomal resources, we developed 11 gene-associated markers for the region of interest, which allowed reducing gene interval and spanning it by four BAC clones. Positional gene cloning and targeted marker development in bread wheat are hampered by high complexity and polyploidy of its nuclear genome. Aiming to clone a Russian wheat aphid resistance gene Dn2401 located on wheat chromosome arm 7DS, we have developed a strategy overcoming problems due to polyploidy and enabling efficient development of gene-associated markers from the region of interest. We employed information gathered by GenomeZipper, a synteny-based tool combining sequence data of rice, Brachypodium, sorghum and barley, and took advantage of a high-density linkage map of Aegilops tauschii. To ensure genome- and locus-specificity of markers, we made use of survey sequence assemblies of isolated wheat chromosomes 7A, 7B and 7D. Despite the low level of polymorphism of the wheat D subgenome, our approach allowed us to add in an efficient and cost-effective manner 11 new gene-associated markers in the Dn2401 region and narrow down the target interval to 0.83 cM. Screening 7DS-specific BAC library with the flanking markers revealed a contig of four BAC clones that span the Dn2401 region in wheat cultivar 'Chinese Spring'. With the availability of sequence assemblies and GenomeZippers for each of the wheat chromosome arms, the proposed strategy can be applied for focused marker development in any region of the wheat genome.

Článek

Posuzování bolesti a ztížení společenského uplatnění dle vyhlášky č. 440/2001 Sb
[Assessment of compensation for pain and worsening of social assertion]

Čeledová, Libuše, 1960-
Autor Autorita
Štaňková, Helena
Autor Autorita
Čevela, Rostislav, 1953-
Autor Autorita

Praktický lékař. 2011 ; 91 (7) : 401-403.

Medvik
Zdroj

Článek seznamuje se stávající a připravovanou právní úpravou posuzování poškození zdraví v důsledku pracovního úrazu dle zákona o úrazovém pojištění zaměstnanců. Jako příklad zvolili autoři posuzování náhrady za bolest a ztížení společenského uplatnění, kterou utrpěl zaměstnanec v souvislosti s pracovním úrazem. V závěru vyjadřují přesvědčení, že navrženým přenesením posuzování škody na zdraví na lékařskou posudkovou službu se zajistí jeho jednotnost a přezkoumatelnost.

The article decribes the existing and upcoming legislation assessing damage to health due to work injury under the Act on Accident Insurance of employees. As an example, the authors chose the assessment of compensation for pain and worsening of social assertion, sustained by an employee in connection with an accident at work. In conclusion, expressing the belief that the proposed transfer of the assessment of health damage to the medical assessment service will ensure its consistency and reviewability.