• MeSH
• imunizace MeSH
• inhibice migrace buněk MeSH
• krevní plazma MeSH
• leukocyty MeSH
• nádory prsu imunologie   MeSH
• pozdní přecitlivělost diagnóza   MeSH

BACKGROUND: Tongue squamous cell carcinoma (TSCC) is increasing in incidence, especially among young patients and preferably females. Infection with human papilloma virus (HPV) has been suggested as a cause of SCC in the head and neck, and the proportion of oropharyngeal cancers caused by HPV has steadily increased. METHODS: Samples from 109 patients with primary TSCC were analysed for the presence of HPV16 by in situ hybridisation and for expression of its surrogate marker p16 and the HPV receptor syndecan-1 by immunhistochemistry. RESULTS: No evidence of HPV16 DNA was observed in the tumours, although one-third showed p16 staining. There was no difference in the expression of the primary HPV receptor, syndecan-1, between TSCC and a group of tonsil SCC. CONCLUSION: Whereas p16 is expressed in some TSCCs, HPV16 is undetectable, therefore, p16 cannot be used as a surrogate marker for high-risk HPV-infection in this tumour. Despite presence of the HPV-receptor syndecan-1 in TSCC, HPV prefers the tonsillar environment. Lack of p16 associates with worse prognosis primarily in patients aged ⩽40 years with tongue SCC. The improved prognosis seen in p16-positive TSCC can be due to induction of a senescent phenotype or an inherent radiosensitivity due to the ability of p16 to inhibit homologous recombination repair.

• MeSH
• DNA virů analýza   MeSH
• dospělí MeSH
• hybridizace in situ MeSH
• infekce papilomavirem komplikace   MeSH
• lidé středního věku MeSH
• lidé MeSH
• lidský papilomavirus 16 izolace a purifikace   MeSH
• nádorové proteiny analýza   fyziologie   MeSH
• nádory hlavy a krku mortalita   virologie   MeSH
• nádory jazyka mortalita   virologie   MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• spinocelulární karcinom mortalita   virologie   MeSH
• syndekan-1 analýza   fyziologie   MeSH
• virové receptory fyziologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

BACKGROUND: c-MYC is a potent oncoprotein with roles in a wide range of cellular processes such as differentiation, apoptosis and growth control. Deregulation of the MYC gene is commonly seen in human tumours resulting in overexpression of the protein. Here we studied expression of c-MYC in correlation to clinical outcome in patients with primary squamous cell carcinoma of the mobile tongue. METHODS: Immunohistochemistry was used to identify c-MYC in a group of 104 tongue squamous cell carcinomas with an antibody directed against the N-terminal part of the protein. Staining was evaluated by multiplying the percentage of c-MYC-expressing cells with staining intensity, giving a quick score for each tumour. RESULTS: All 104 tumours expressed c-MYC at varying levels. Quantitation according to per cent of positive cells and staining intensity revealed that most (15/21; 71%) high-expressing tumours were seen in males. Within the group of high c-MYC-expressing tumours, the majority were alive 2 and 5 years after treatment. CONCLUSIONS: The present findings show that expression of c-MYC has prognostic value in squamous cell carcinoma of the tongue, and could be useful in choice of therapy.

• MeSH
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• míra přežití MeSH
• mladý dospělý MeSH
• nádory hlavy a krku genetika   metabolismus   mortalita   MeSH
• nádory jazyka genetika   metabolismus   mortalita   MeSH
• protoonkogenní proteiny c-myc biosyntéza   genetika   MeSH
• regulace genové exprese u nádorů * MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• spinocelulární karcinom genetika   metabolismus   mortalita   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• senioři nad 80 let MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• srovnávací studie MeSH

Squamous cell carcinoma of the head and neck, SCCHN, is a heterogeneous group of tumours not only concerning the site of origin but also regarding aetiology. The 5-year survival for the whole group of SCCHN tumours has not significantly improved over the last 20-25 years. Apart from tumour spread to lymph nodes, N status, gains and losses of specific chromosomes are the only factors shown to be independent prognostic markers for these tumours. Worldwide, an increasing number of people ≤ 40 years are seen being affected by tongue SCC, the most common tumour within the SCCHN group. Even without any clinical signs of metastasis, up to 30% of all tongue SCC have histologically detectable spread to lymph nodes. In this mini review, field cancerization, tumour microenvironment, the so called EMT (epithelial mesenchymal transition) process and the role of viruses in development of SCCHN are discussed as well as potential new therapeutic targets. For the group of tongue SCC, with the increasing incidence seen in young patients and particularly women, new data with impact on prognosis and treatment are urgently needed. But as long as data from the analyses of several sub sites are presented as valid for the whole group of tumours, this vital point is missed.

• MeSH
• antivirové látky chemie   farmakologie   MeSH
• lidé MeSH
• mikrobiální testy citlivosti MeSH
• nádorové mikroprostředí účinky léků   MeSH
• nádory hlavy a krku farmakoterapie   virologie   MeSH
• nádory jazyka farmakoterapie   virologie   MeSH
• Papillomaviridae účinky léků   MeSH
• protinádorové látky chemie   farmakologie   MeSH
• screeningové testy protinádorových léčiv MeSH
• spinocelulární karcinom farmakoterapie   virologie   MeSH
• virus Epsteinův-Barrové účinky léků   MeSH
• vztahy mezi strukturou a aktivitou MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

The oral tongue is the most common site for tumours within the oral cavity. Despite intense research, there has been no improvement in the survival rate for patients with oral tongue squamous cell carcinoma (OTSCC) during the last decades. Differences between oral cancer patients based on ethno-geographical distribution have been reported. The present study used immunohistochemistry to evaluate commonly used markers of cancer cell phenotypes, E-cadherin, β-catenin and cytokeratins 5 and 19, in 120 patients with OTSCC. To evaluate the impact of ethnicity, patients from Sweden and Italy were included. A higher proportion of Swedish patients exhibited high expression of E-cadherin in their tumours (P=0.039), and high levels of E-cadherin in Swedish OTSCC patients that had succumbed to their disease were associated with poor prognosis. These data demonstrated differences in the pathological characteristics of OTSCC between two different European populations. The findings emphasise the need to take ethnicity/geographical location of patients into account when comparing results from different studies of OTSCC.

• Publikační typ
• časopisecké články MeSH

Cíl studie: Zjistit, jak se liší hladiny deprese, úzkosti a frustrace u žen a mužu před in vitrofertilizací (IVF) v závislosti na příčině sterility.Typ studie: Prospektivní studie.Název a sídlo pracoviště: Gynekologicko-porodnická klinika 1. LF UK a VFN, Apolinářská 18,Praha 2.Metodika: Soubor 66 sterilních páru před léčbou pomocí IVF byl vyšetřen pomocí Beckova dotazníku deprese, Dotazníku na mioení úzkosti a úzkostnosti STAI a Dotazníku Dusin pro zjišťovánímíry frustrace. Byly srovnány a statisticky zhodnoceny výsledky mužu a žen v podskupinách s andrologickým a gynekologickým faktorem sterility.Výsledky V párech s gynekologickou příčinou sterility jsou statisticky významně vyšší skóry deprese a úzkosti u žen než u mužu, v párech s andrologickou příčinou sterility nejsou mezi mužia ženami statistické rozdíly. V míře frustrace není mezi muži a ženami v obou skupinách rozdíl.Závěr ženy jsou zřejmš silnšji poznamenány pocitem odpovšěnosti za příčinu sterility než jejichpartneři. To se v párech s gynekologickou sterilitou projevuje na jejich vyšší míře deprese a úzkosti poed cyklem IVF.

Objecive: Testing the depression, anxiety and/or frustration differences between women and mencoming for IVF treatment, depending on cause of infertility.Design: Prospective study.Setting: Assisted Reproduction Centre, Gynecology and Obstetrics Department, 1stMedical Faculty of Charles University, Apolinářská 18, Prague 2, 128 00 Czech Republic.Methods:66 infertile couples before IVF treatment were subjected to Becks Depression Inventory,State-Trait Anxiety Inventory and Dusin frustration test. Obtained test results were statisticallyprocessed and correlated to male of female factor of infertility.Results:The depression and anxiety scores in couples with female infertility factor were significantly higher (p < 0.05) in women than in man, while among couples with male infertility factorthe results of men and women were not significantly different.Conclusion: Women probably more suffer from guilty feeling in case of couple infertility thantheir partners. This phenomenon was expressed through higher depression and anxiety degree inwomen in couples with female infertility factor.

• MeSH
• deprese patologie   MeSH
• dospělí MeSH
• fertilizace in vitro MeSH
• infertilita psychologie   MeSH
• lidé MeSH
• pohlavní dimorfismus MeSH
• prospektivní studie MeSH
• úzkostné poruchy patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH

• MeSH
• diabetes mellitus 1. typu MeSH
• dítě MeSH
• lidský růstový hormon MeSH
• poruchy růstu MeSH
• tělesná výška MeSH
• Check Tag
• dítě MeSH
• Publikační typ
• kongresy MeSH
• sborníky MeSH
• zprávy MeSH

• Konspekt
• Pediatrie
• NLK Obory
• pediatrie
• diabetologie