Stanovení složení tělesných tekutin a posouzení jejich dynamiky u dětí v různých stádiích chronické renální insuficience pomocí antropometrie,bioimpedance a celotělové denzitometrie.Korelace RTG denzitometrie s ultrazvukovou denzitometrií.

• MeSH
• chronické selhání ledvin komplikace   MeSH
• metabolické nemoci kostí diagnóza   MeSH
• poruchy růstu MeSH
• složení těla MeSH
• vývojové poruchy u dětí MeSH

• Konspekt
• Lékařské vědy. Lékařství
• NLK Obory
• nefrologie
• ortopedie
• urologie
• NLK Publikační typ
• závěrečné zprávy o řešení grantu IGA MZ ČR

BACKGROUND: Recombinant human growth hormone (rhGH) is an anabolic hormone promoting protein synthesis in various tissues. Therefore, changes in body composition may be expected during rhGH treatment. METHODS: We studied changes in body composition during two years of rhGH treatment in 21 children after at least one year with a functioning renal transplant. The mean +/- SD age was 12.9+/-2.5 years at the start of rhGH therapy. A whole body, dual energy X-ray absorptiometry (DEXA) exam was performed before the initiation of rhGH therapy (T0), and was repeated at one and two year intervals after initiation of the therapy (T1 and T2, respectively). RESULTS: Lean body mass increased by a median of 0.48 SDS during the first year of treatment (P = 0.022), and the median increase during two years of therapy was 0.36 SDS (P = 0.061). On the contrary, the median fat body mass decreased by 2.17 SDS during the T0 to T1 period (P = 0.04) and by 1.99 SDS during the T0 to T2 period (P = 0.055). The index for fat body mass/lean body mass (FBM/LBM) decreased by a median of 5.3% during T0 to T1 (P < 0.001), however, a slower but still significant decrease by a median of 4.2% was noted at T2 (P < 0.05). Bone mass content did not change significantly during rhGH treatment. The medians in caloric and protein intakes were stable during rhGH treatment. CONCLUSION: A significant increase of lean body mass and a decrease of fat body mass was noted during rhGH therapy in children after renal transplantation.

• MeSH
• dítě MeSH
• kostní denzita účinky léků   MeSH
• lidé MeSH
• mladiství MeSH
• růstový hormon * farmakologie   MeSH
• složení těla * účinky léků   MeSH
• transplantace ledvin * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• Publikační typ
• práce podpořená grantem MeSH

• MeSH
• denzitometrie metody   MeSH
• dialýza ledvin MeSH
• dítě MeSH
• lidé MeSH
• nutriční stav MeSH
• transplantace ledvin MeSH
• Check Tag
• dítě MeSH
• lidé MeSH

Body composition using standard anthropometric methods and dual-energy X-ray absorptiometry (DEXA) was determined in a cross-sectional study among 26 pediatric renal transplant recipients. At the same time, spiroergometry exam, pulmonary function tests, dynamometry and tremometry exams were performed in all patients. Fat body mass obtained by DEXA correlated inversely with maximal physical load during spiroergometry exam (r2 = 0.51, p = 0.0001). The study demonstrates good tolerance of increased physical load in children after renal transplantation. An inverse relationship was found between fat body mass and physical performance. Exercise training programs for children after renal transplantation are therefore suggested.

• MeSH
• absorpční fotometrie MeSH
• chronické selhání ledvin chirurgie   MeSH
• cvičení * fyziologie   MeSH
• dítě MeSH
• ergometrie MeSH
• hemodynamika MeSH
• index tělesné hmotnosti MeSH
• lidé MeSH
• mladiství MeSH
• pooperační období MeSH
• složení těla * fyziologie   MeSH
• spirometrie MeSH
• transplantace ledvin * MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• práce podpořená grantem MeSH

• Publikační typ
• abstrakty MeSH

Dual energy X-ray absorptiometry (DEXA) is a non-invasive accurate method which estimates bone mineral content and density (BMD), as well as fat (FM) and lean (LM) body mass. This method was used in control children in order to establish normal values for BMD of lumbar spine and whole body composition ?logistic curves, general equation E = k+K/[1+ alpha exp(- beta A)]?. In children with chronic renal failure (CRF), LM correlated with the urinary excretion of creatinine (r = 0.97, P = 0.0001) independently from glomerular filtration rate. However, the assessment of LM by DEXA must take into account the hydration level, since there is a positive correlation between fluid loss and reduction in LM in children on hemodialysis (r = 0.98, P = 0.0001). After renal transplantation, a significant loss of BMD (median -9.2%) was observed at 6 months which returned to 95% of pretransplant values by the end of the 1st year. Maximal changes in LM and FM occurred during the first 3 months (-7.8% and +7.2%, respectively) and may be due to steroids; these should be influenced by physical activity since FM correlated inversely with maximal oxygen consumption (r = 0.69, P = 0.0001). Recombinant growth hormone treatment could also increase LM and decrease FM, as shown in 9 patients. DEXA appears therefore to be a reliable method for evaluating therapeutic interventions affecting nutritional status in children with CRF.

• MeSH
• absorpční fotometrie MeSH
• chronické selhání ledvin * chirurgie   metabolismus   radiografie   MeSH
• dialýza ledvin MeSH
• dítě MeSH
• dospělí MeSH
• hodnoty glomerulární filtrace MeSH
• kojenec MeSH
• kostní denzita fyziologie   účinky léků   MeSH
• lidé MeSH
• mladiství MeSH
• páteř metabolismus   MeSH
• předškolní dítě MeSH
• růstový hormon škodlivé účinky   terapeutické užití   MeSH
• složení těla * fyziologie   MeSH
• spotřeba kyslíku fyziologie   MeSH
• transplantace ledvin MeSH
• Check Tag
• dítě MeSH
• dospělí MeSH
• kojenec MeSH
• lidé MeSH
• mladiství MeSH
• mužské pohlaví MeSH
• předškolní dítě MeSH
• ženské pohlaví MeSH