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Přesná shoda Sémantické

We pooled immunogenetic data obtained in independent studies in two European populations (Italian and Czech) of patients affected by sarcoidosis. Correspondence analysis was used to investigate the associations between clinical and immunogenetic data. Two hundred and thirty-three patients were enrolled in the study, of which 126 were from the Czech Republic and 107 from Italy. Using a common protocol, we examined each patient for sex, age of disease onset, roentgenologic stage, extrapulmonary spread, and clinical course. One thousand and ten healthy individuals, HLA typed for class I and II serologic polymorphisms, served as controls. Findings that were essentially in agreement in both populations were: (1) a positive association of sarcoidosis with HLA-A1, B8, and DR3 markers, and a negative association with HLA-B12 and DR4; (2) a prevalence of HLA-DR3 and DR4 among females and of DR5 among males; (3) a relationship of B13 and B35 with early onset and of A30, B8, DR3, and DR4 with late onset of disease; (4) an association of B27 with sarcoidosis restricted to the lungs; (5) a relationship of A1, B8, B27, and DR3 to roentgenologic stage I and of B12 and DR4 to stage III; and (6) an association of HLA-DR3 with a good outcome. Population-restricted findings essentially concerned the alleles HLA-B13 and B22, the former being associated with the disease, male sex, early onset, extrapulmonary localization and relapse only in Czechs, and the latter to disease spread only in Italians. Our results seem to support the concept that immunogenetic background may at least partly account for the clinical heterogeneity of sarcoidosis.

MeSH
alely MeSH
dospělí MeSH
HLA antigeny * genetika MeSH
HLA-A antigeny genetika MeSH
HLA-A1 antigen genetika MeSH
HLA-B antigeny genetika MeSH
HLA-B27 antigen genetika MeSH
HLA-B35 antigen genetika MeSH
HLA-B8 antigen genetika MeSH
HLA-DR3 antigen genetika MeSH
HLA-DR4 antigen genetika MeSH
HLA-DR5 antigen genetika MeSH
imunogenetika MeSH
lidé MeSH
plicní nemoci genetika imunologie MeSH
polymorfismus genetický genetika MeSH
sarkoidóza genetika imunologie patologie radiografie MeSH
sexuální faktory MeSH
studie případů a kontrol MeSH
věk při počátku nemoci MeSH
Check Tag
dospělí MeSH
lidé MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH
Publikační typ
práce podpořená grantem MeSH
Geografické názvy
Česká republika MeSH
Itálie MeSH

Článek online

Lokalizovaná laryngotracheobronchiální amyloidóza
[Localized laryngotracheobronchial amyloidosis]

Studia pneumologica et phtiseologica. 1995 ; Roč. 55 (č. 1) : s. 41-45.

ISSN 0371-2222
Medvik
Zdroj

MeSH
amyloidóza diagnóza klasifikace patologie MeSH
atelektáza patofyziologie patologie MeSH
bronchiální nemoci MeSH
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
nemoci laryngu diagnóza etiologie patologie MeSH
nemoci průdušnice MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
ženské pohlaví MeSH
Publikační typ
kazuistiky MeSH

Článek online

Epidemiology of cryptogenic fibrosing alveolitis in Moravia and Silesia

Kolek, Vítězslav, 1953-2020
Autor Autorita ORCID Dept. of Tuberculosis and Pulmonary Diseases, University Hospital, Olomouc, Czech Republic

Acta Universitatis Palackianae Olomucensis Facultatis medicae. Biomedical papers. 1994 ; 137 () : 49-50. (Biomedical papers)

Acta Univ. Palacki. Olomuc. Fac. med., Biomed. Pap.
ISSN 0862-481X
Medvik
Zdroj

Cryptogenic fibrosing alveolitis in Moravia and Silesia (4 million inhabitants) was evaluated using standard epidemiological and clinical parameters. During 1981-1990 the incidence of cryptogenic fibrosing alveolitis ranged from 0.74 to 1.28/100,000. The trend of incidence was increasing slightly. The prevalence rose from 6.5 to 12.1/100,000. The male/female ratio was 1:1.2; 54% of patients were less than 40 years old. Biopsy (mostly open lung biopsy) supported the diagnosis in 38% of cases. During 1981-1990 years 379 new cases were detected, 488 cases altogether were registered up to 1990. The death rate calculated by incidence and prevalence was 13% and 10% resp. The mean regional incidences varied from 0.34 to 2.69/100,000, regional prevalences varied from 4.1 to 27.6/100,000. No correlation with the regional incidences of sarcoidosis and tuberculosis was found. No significant differences in coal mining areas with a high occurrence of pneumoconiosis or in areas with developed agriculture were detected. Significantly higher values were found in the regions of the four major diagnostic centres: a mean incidence of 1.58/100,000 and a mean prevalence of 20.8/100,000 (p < 0.05). The results suggest that the level of diagnostic possibilities and efforts dominates over ecological and environmental factors in the detecting of cryptogenic fibrosing alveolitis.