Cranberries
Dotaz
Zobrazit nápovědu
Brusinka je známá po staletí, jejím původním domovem je Severní Amerika, hodí se do slaných i sladkých jídel, ale popularitu jim zajistily spíše léčebné účinky.
Cranberry has been known for centuries, its original home is North America. It is suitable for use in both salty and sweet dishes, but rather became popular due to its therapeutic effects.
- Klíčová slova
- močové cesty, klinické studie, recepty na úpravu,
- MeSH
- dospělí MeSH
- fytoterapie metody MeSH
- infekce močového ústrojí * farmakoterapie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- prospektivní studie MeSH
- recidiva MeSH
- rostlinné extrakty aplikace a dávkování terapeutické užití MeSH
- sekundární prevence MeSH
- Vaccinium macrocarpon * MeSH
- výsledek terapie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladiství MeSH
- mladý dospělý MeSH
- ženské pohlaví MeSH
Lower urinary tract symptoms (LUTS) are a common condition in older men. The objective of the present study was to evaluate the efficacy and tolerability of cranberry (Vaccinium macrocarpon) powder in men at risk of prostate disease with LUTS, elevated prostate-specific antigen (PSA), negative prostate biopsy and clinically confirmed chronic non-bacterial prostatitis. Forty-two participants received either 1500 mg of the dried powdered cranberries per d for 6 months (cranberry group; n 21) or no cranberry treatment (control group; n 21). Physical examination, International Prostate Symptom Score, quality of life (QoL), five-item version of the International Index of Erectile Function (IIEF-5), basic clinical chemistry parameters, haematology, Se, testosterone, PSA (free and total), C-reactive protein (CRP), antioxidant status, transrectal ultrasound prostate volume, urinary flow rate, ultrasound-estimated post-void residual urine volume at baseline, and at 3 and 6 months, and urine ex vivo anti-adherence activity were determined in all subjects. In contrast to the control group, patients in the cranberry group had statistically significant improvement in International Prostate Symptom Score, QoL, urination parameters including voiding parameters (rate of urine flow, average flow, total volume and post-void residual urine volume), and lower total PSA level on day 180 of the study. There was no influence on blood testosterone or serum CRP levels. There was no statistically significant improvement in the control group. The results of the present trial are the first firm evidence that cranberries may ameliorate LUTS, independent of benign prostatic hyperplasia or C-reactive protein level.
- MeSH
- hyperplazie prostaty patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- ovoce MeSH
- poruchy močení dietoterapie MeSH
- prášky, zásypy, pudry MeSH
- prostata MeSH
- senioři MeSH
- tobolky MeSH
- Vaccinium macrocarpon MeSH
- Check Tag
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- senioři MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- randomizované kontrolované studie MeSH
The use of dietary supplements containing cranberry extract is a common way to prevent urinary tract infections. As consumption of these supplements containing a mixture of concentrated anthocyanins and proanthocyanidins has increased, interest in their possible interactions with drug-metabolizing enzymes has grown. In this in vivo study, rats were treated with a standardized cranberry extract (CystiCran®) obtained from Vaccinium macrocarpon in two dosage schemes (14 days, 0.5 mg of proanthocyanidins/kg/day; 1 day, 1.5 mg of proanthocyanidins/kg/day). The aim of this study was to evaluate the effect of anthocyanins and proanthocyanidins contained in this extract on the activity and expression of intestinal and hepatic biotransformation enzymes: cytochrome P450 (CYP1A1, CYP1A2, CYP2B and CYP3A), carbonyl reductase 1 (CBR1), glutathione-S-transferase (GST) and UDP-glucuronosyl transferase (UGT). Administration of cranberry extract led to moderate increases in the activities of hepatic CYP3A (by 34%), CYP1A1 (by 38%), UGT (by 40%), CBR1 (by 17%) and GST (by 13%), while activities of these enzymes in the small intestine were unchanged. No changes in the relative amounts of these proteins were found. Taken together, the interactions of cranberry extract with simultaneously administered drugs seem not to be serious.
- MeSH
- biotransformace MeSH
- játra účinky léků enzymologie MeSH
- krysa rodu rattus MeSH
- potkani Wistar MeSH
- rostlinné extrakty farmakologie MeSH
- střeva účinky léků enzymologie MeSH
- Vaccinium macrocarpon chemie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Přehledový článek shrnující dosavadní znalosti o alternativních terapeutických metodách – podávání brusinek a probiotik v léčbě a prevenci infekcí dolních močových cest. Pravidelné užívání brusinkových přípravků po dobu 6–12 měsíců snižuje počet recidiv infekcí dolních močových cest u žen mladšího a středního věku. Slibné výsledky jsou popisovány při podávání probiotik v prevenci a léčbě vaginálních infekcí, zejména bakteriální vaginózy. K validnímu zhodnocení vlivu probiotik na infekce močových cest je třeba dalšího výzkumu a rozsáhlejších studií.
Review article on current knowledges of alternative treatment methods – using of cranberry extract and probiotics – in the lower urinary tract infection therapy and prevention. Regular using of cranberry products during 6–12 month reduces the number of recurences of lower urinary tract infections in young and middle-aged women. Promising results are described in probiotics used for prevention and treatment of vaginal infections, especially bacterial vaginosis. Further research and larger studies evaluating the effect of probiotics in lower urinary tract infection are required.
- MeSH
- fytoterapie metody MeSH
- lidé MeSH
- probiotika terapeutické užití MeSH
- recidiva MeSH
- rostlinné extrakty terapeutické užití MeSH
- sekundární prevence MeSH
- Vaccinium macrocarpon MeSH
- věkové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Most research on American cranberry in the prevention of urinary tract infection (UTI) has used juices. The spectrum of components in juice is limited. This study tested whether whole cranberry fruit powder (proanthocyanidin content 0.56%) could prevent recurrent UTI in 182 women with two or more UTI episodes in the last year. Participants were randomized to a cranberry (n = 89) or a placebo group (n = 93) and received daily 500 mg of cranberry for 6 months. The number of UTI diagnoses was counted. The intent-to-treat analyses showed that in the cranberry group, the UTIs were significantly fewer [10.8% vs. 25.8%, p = 0.04, with an age-standardized 12-month UTI history (p = 0.01)]. The Kaplan-Meier survival curves showed that the cranberry group experienced a longer time to first UTI than the placebo group (p = 0.04). Biochemical parameters were normal, and there was no significant difference in urinary phenolics between the groups at baseline or on day180. The results show that cranberry fruit powder (peel, seeds, pulp) may reduce the risk of symptomatic UTI in women with a history of recurrent UTIs.
- MeSH
- dospělí MeSH
- infekce močového ústrojí * farmakoterapie prevence a kontrola MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- ovoce MeSH
- proantokyanidiny MeSH
- rostlinné extrakty terapeutické užití MeSH
- semena rostlinná MeSH
- Vaccinium macrocarpon * chemie MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Přehledový článek shrnující dosavadní znalosti o alternativních terapeutických metodách – podávání brusinek a probiotik v léčbě a prevenci infekcí dolních močových cest. Pravidelné užívání brusinkových přípravků po dobu 6–12 měsíců snižuje počet recidiv infekcí dolních močových cest u žen mladšího a středního věku. Slibné výsledky jsou popisovány při podávání probiotik v prevenci a léčbě vaginálních infekcí, zejména bakteriální vaginózy. K validnímu zhodnocení vlivu probiotik na infekce močových cest je třeba dalšího výzkumu a rozsáhlejších studií.
Review article on current knowledges of alternative treatment methods – using of cranberry extract and probiotics – in the lower urinary tract infection therapy and prevention. Regular using of cranberry products during 6–12 month reduces the number of recurences of lower urinary tract infections in young and middle-aged women. Promising results are described in probiotics used for prevention and treatment of vaginal infections, especially bacterial vaginosis. Further research and larger studies evaluating the effect of probiotics in lower urinary tract infection are required.
- Klíčová slova
- infekce močových cest, močová inkontinence,
- MeSH
- fytoterapie metody MeSH
- infekce močového ústrojí prevence a kontrola MeSH
- lidé MeSH
- probiotika terapeutické užití MeSH
- recidiva MeSH
- rostlinné extrakty terapeutické užití MeSH
- sekundární prevence MeSH
- Vaccinium macrocarpon MeSH
- věkové faktory MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- přehledy MeSH
Cranberry (Vaccinium macrocarpon Ait. Ericaceae) fruits and juice are widely used for their antiadherence and antioxidative properties. Little is known however about their effects on clinical chemistry markers after long-term consumption. This study was conducted to evaluate the effect of three commercial cranberry products, NUTRICRAN90S, HI-PAC 4.0, and PACRAN on the antioxidative status of rodents, divided into three experimental groups. The products were given as dietary admixtures (1500 mg of product/kg of stock feed) for 14 weeks to male Wistar rats (Groups 2-4) and a control Group 1 which received only stock feed. There were no significant cranberry treatment-related effects on oxidative stress parameters, catalase, glutathione peroxidase, glutathione reductase, glutathione transferase, superoxide dismutase, total antioxidant capacity, thiobarbituric acid reactive substances, advanced oxidation protein products, total SH-groups, or any other measured clinical chemistry markers. Hematological parameters, body weight, and food consumption were also unaffected by intake of cranberries. Only liver glutathione reductase activity and glutathione levels were significantly lower in Group 4 than in Group 1. Plasma alkaline phosphatase alone was significantly decreased in Group 2. No gross pathology, effects on organ weights, or histopathology were observed. No genotoxicity was found, and total cytochrome P450 level in liver was unaffected in all groups. The levels of hippuric acid and several phenolic acids were significantly increased in plasma and urine in Groups 2-4. The concentration of anthocyanins was under the detection threshold. The dietary addition of cranberry powders for 14 weeks was well tolerated, but it did not improve the antioxidative status in rats.
- MeSH
- antioxidancia aplikace a dávkování farmakologie MeSH
- glutathionperoxidasa metabolismus MeSH
- katalasa metabolismus MeSH
- krysa rodu rattus MeSH
- oxidační stres účinky léků MeSH
- pilotní projekty MeSH
- potkani Wistar MeSH
- rostlinné přípravky aplikace a dávkování farmakologie MeSH
- Vaccinium macrocarpon chemie MeSH
- zvířata MeSH
- Check Tag
- krysa rodu rattus MeSH
- mužské pohlaví MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- Research Support, N.I.H., Extramural MeSH
