- MeSH
- Algorithms MeSH
- Anesthesia, General methods adverse effects utilization MeSH
- Evaluation Studies as Topic MeSH
- Intubation methods utilization MeSH
- Humans MeSH
- Monitoring, Physiologic MeSH
- Critical Care methods utilization MeSH
- Pulmonary Ventilation MeSH
- Signal Processing, Computer-Assisted MeSH
- Dogs MeSH
- Statistics as Topic MeSH
- Models, Theoretical MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Dogs MeSH
- Animals MeSH
- MeSH
- Algorithms MeSH
- Anesthesia adverse effects MeSH
- Asphyxia diagnosis etiology complications MeSH
- Fractals MeSH
- Fetal Hypoxia diagnosis etiology complications MeSH
- Pregnancy Complications diagnosis etiology MeSH
- Humans MeSH
- Computer Simulation trends utilization MeSH
- Heart Rate, Fetal physiology MeSH
- Heart Arrest diagnosis etiology complications MeSH
- Models, Theoretical MeSH
- Education MeSH
- Check Tag
- Humans MeSH
- MeSH
- Financing, Organized MeSH
- Infusion Pumps, Implantable trends utilization MeSH
- Central Nervous System Agents administration & dosage adverse effects therapeutic use MeSH
- Humans MeSH
- Analgesics, Opioid administration & dosage adverse effects therapeutic use MeSH
- Opioid-Related Disorders prevention & control psychology MeSH
- Surveys and Questionnaires standards utilization MeSH
- Psychological Tests standards statistics & numerical data MeSH
- Psychosocial Deprivation MeSH
- Anesthesia, Spinal methods trends utilization MeSH
- Patient Satisfaction statistics & numerical data MeSH
- Statistics as Topic methods MeSH
- Models, Theoretical MeSH
- Outcome and Process Assessment, Health Care methods utilization MeSH
- Check Tag
- Humans MeSH
OBJECTIVES: The default mode resting state network (DMRSN) constitutes a circuit which is active in conditions when the subject is at rest. We tested the hypothesis that its function will be altered during unconsciousness. METHODS: Changes in the mean squared coherences in five conventional frequency bands (delta to gamma) in DMRSN during general anaesthesia (GA) were investigated in 39 patients. They were compared with the normal EEG of 86 alert subjects, severely abnormal EEG of 112 patients with dementia and/or encephalopathy, and the mathematical model of brain death. RESULTS: Anaesthetised patients showed significant decrease in the gamma coherence in the posterior area of the DMRSN compared to both the control group and the patients with dementia and/or encephalopathy. Among the anaesthetized patients 21 had a clear burst suppression pattern with prolonged epochs of suppression in EEG. In suppressed EEG segment the differences between the connections of the anterior to posterior parts and connections between the posterior parts of the DMRSN were almost lost. However, they still showed highly significant differences in most items when compared with coherences in the mathematical model of brain death. CONCLUSION: The functional connectivity in the DMRSN could be a reliable and robust method for assessing the depth of anaesthesia and maybe also disorders of consciousness in general. The mean squared coherences in the gamma frequency band indicated the highest sensitivity for the depth of unconsciousness. The measure is not dependent on the diffused slowing in dementia or encephalopathy patients as long as they remain in a full consciousness.
- MeSH
- Alpha Rhythm physiology MeSH
- Unconsciousness physiopathology MeSH
- Anesthesia, General * MeSH
- Delta Rhythm physiology MeSH
- Child MeSH
- Adult MeSH
- Electroencephalography MeSH
- Middle Aged MeSH
- Humans MeSH
- Brain Mapping methods MeSH
- Adolescent MeSH
- Young Adult MeSH
- Brain physiopathology MeSH
- Nerve Net physiopathology MeSH
- Neural Pathways physiopathology MeSH
- Rest physiology MeSH
- Aged MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
