Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) with anti-inflammatory, anti-catabolic and pro-anabolic properties on cartilage and synovial membrane. It has also recently been shown to have protective effects against subchondral bone remodelling. Following the end of the revision procedure by the Pharmacovigilance Risk Assessment Committee of the European Medicines Agency, the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) constituted a panel of 11 experts to better define the real place of diacerein in the armamentarium for treating OA. Based on a literature review of clinical trials and meta-analyses, the ESCEO confirms that the efficacy of diacerein is similar to that of non-steroidal anti-inflammatory drugs (NSAIDs) after the first month of treatment, and superior to that of paracetamol. Additionally, diacerein has shown a prolonged effect on symptoms of several months once treatment was stopped. The use of diacerein is associated with common gastrointestinal disorders such as soft stools and diarrhoea, common mild skin reactions, and, uncommonly, hepatobiliary disorders. However, NSAIDs and paracetamol are known to cause potentially severe hepatic, gastrointestinal, renal, cutaneous and cardiovascular reactions. Therefore, the ESCEO concludes that the benefit-risk balance of diacerein remains positive in the symptomatic treatment of hip and knee osteoarthritis. Furthermore, similarly to other SYSADOAs, the ESCEO positions diacerein as a first-line pharmacological background treatment of osteoarthritis, particularly for patients in whom NSAIDs or paracetamol are contraindicated.

• MeSH
• Anthraquinones pharmacology   MeSH
• Anti-Inflammatory Agents pharmacology   MeSH
• Pharmacovigilance MeSH
• Risk Assessment MeSH
• Delayed-Action Preparations pharmacology   MeSH
• Humans MeSH
• Osteoarthritis * drug therapy   physiopathology   MeSH
• Bone Remodeling drug effects   MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH
• Review MeSH

The aim of this study was to calculate rates of hospitalization for hip fracture and the incidence of hip fractures in the Czech Republic over a period of 29 years. A second aim was to use the most recent data to populate a FRAX(®) model for the assessment of fracture probability in individual patients. Data on hospitalizations for hip fracture (1981-2009) and number of women and men with hip fractures (2000-2009) were obtained, and incidences were computed for the entire population ≥50 years of age. Incidence of hospitalization for hip fracture in the Czech population aged ≥50 years increased progressively by calendar year. Age-standardized incidence of hip fractures increased to 2004 but leveled off thereafter and decreased after 2005. Data for hip fracture risk in 2008 and 2009 and the death hazard were used to populate a Czech-specific FRAX model for the computation of 10-year fracture probability. The customized FRAX model, using the verified epidemiological data, will be used to identify patients at increased fracture risk.

• MeSH
• Hip Fractures epidemiology   etiology   MeSH
• Bone Density physiology   MeSH
• Middle Aged MeSH
• Humans MeSH
• Osteoporosis complications   epidemiology   MeSH
• Risk Factors MeSH
• Aged MeSH
• Check Tag
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH
• Geographicals
• Czech Republic MeSH

• Publication type
• Abstracts MeSH

• MeSH
• Osteoporosis diagnosis   therapy   MeSH

• Publication type
• Abstracts MeSH

• MeSH
• Biomarkers MeSH
• Osteoporosis diagnosis   MeSH
• Prognosis MeSH

• MeSH
• Bone Diseases metabolism   MeSH
• Osteoporosis MeSH
• Publication type
• Monograph MeSH

• Conspectus
• Ortopedie. Chirurgie. Oftalmologie
• NML Fields
• ortopedie

• Publication type
• Textbook MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• revmatologie

• MeSH
• Kidney Failure, Chronic MeSH
• Chronic Kidney Disease-Mineral and Bone Disorder etiology   MeSH
• Calcium metabolism   MeSH
• Vitamin D metabolism   MeSH
• Publication type
• Congress MeSH

• Conspectus
• Patologie. Klinická medicína
• NML Fields
• nefrologie
• urologie

• MeSH
• Diphosphonates MeSH
• Hyperthyroidism physiopathology   MeSH
• Immunologic Factors MeSH
• Bone and Bones physiopathology   metabolism   MeSH
• Bone Diseases, Metabolic drug therapy   MeSH
• Publication type
• Collected Work MeSH

• Conspectus
• Fyziologie člověka a srovnávací fyziologie
• NML Fields
• vnitřní lékařství
• endokrinologie