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PURPOSE OF REVIEW: To describe the direct and indirect effects of estrogen on bone with special emphasis on the analysis of the recent findings related to the putative role of FGF23 in the estrogen-dependent parathyroid hormone (PTH) suppression. RECENT FINDINGS: Estrogens act directly on bone cells, downregulating osteoclast precursors and differentiation, increasing osteoclast apoptosis and stimulating osteoblast proliferation and differentiation. However, estrogens can also act indirectly on bone, modulating the calcium-phosphorus-vitamin D-PTH axis. It has been recently demonstrated that estrogens suppress PTH synthesis and secretion in a dose-dependent manner and reduce serum calcitriol and phosphorus levels by an indirect mechanism. In-vivo and in-vitro experiments demonstrated that FGF23 positively correlated, also in a dose-dependent manner, with the dose of estrogens and with the observed changes in calcitriol and phosphorus. SUMMARY: These new findings support the importance of the indirect effects of estrogens on bone, suggesting a role for FGF23 in the regulation of PTH by estrogens.

MeSH
chronické selhání ledvin komplikace metabolismus MeSH
estrogeny farmakologie fyziologie metabolismus MeSH
fibroblastové růstové faktory metabolismus MeSH
financování organizované MeSH
kosti a kostní tkáň metabolismus účinky léků MeSH
lidé MeSH
nemoci kostí etiologie metabolismus MeSH
parathormon fyziologie MeSH
signální transdukce MeSH
vitamin D fyziologie MeSH
zvířata MeSH
Check Tag
lidé MeSH
zvířata MeSH
Publikační typ
přehledy MeSH

Článek

Noninvasive methods of tibiofemoral angle assessment in clinical practice

Pohybové ústrojí. Pokroky ve výzkumu, diagnostice a terapii. 2008 ; 15 (1-2 Suppl.) : 130-134.

ISSN 1212-4575
Medvik
Zdroj

Kubátův podologický den. 2008 ; 15 (1-2 Suppl.) : 130-134.

Medvik
Zdroj

MeSH
achondroplazie MeSH
antropometrie MeSH
diagnostické zobrazování MeSH
dítě MeSH
femur patologie MeSH
fyzikální vyšetření statistika a číselné údaje MeSH
interpretace statistických dat MeSH
kohortové studie MeSH
kolenní kloub patologie MeSH
nemoci kostí metabolismus MeSH
osteochondrodysplazie MeSH
rentgenové záření MeSH
tibie patologie MeSH
Check Tag
dítě MeSH
Publikační typ
grafy a diagramy MeSH
kongresy MeSH

Článek

Kostní denzita u diabetiků 1. typu obou pohlaví s ohledem na složení kosti
[Bone mineral density of both genders in Type 1 diabetes according to bone composition]

Journal of Diabetes and its Complications (České vyd.). 2007 ; 5 (2) : 110-116.

ISSN 1214-0937
Medvik
Zdroj

AIMS: This study is an investigation of the impact of Type 1 diabetes on bone mineral density (BMD) with regard to bone composition. MATERIAL AND METHODS: Thirty male and 30 premenopausal female patients with Type 1 diabetes (IDD) were retrospectively compared with an equal number of healthy individuals, matched on a person-to-person basis and to the reference population mean. BMD was measured at the L2-L4 vertebrae and femoral neck (FN) by dual energy X-ray absorptiometry (DXA). RESULTS: BMD absolute values were significantly lower in the diabetic than in the healthy males at vertebrae and FN (P<.05). The vertebral BMD values of diabetic women did not significantly differ, whereas those of FN were significantly lower compared with those of the healthy participants. FN age-adjusted BMD values (Z scores) were significantly lower than those of the healthy persons and the population reference mean in both genders (P=.01, <.001 for males and <.01 for females), whereas regarding the vertebrae, only in the diabetic males (P<.05 and <.01 respectively). The percentages of osteopenia and osteoporosis were significantly higher in the male compared to the female diabetic patients (P<.001). No significant correlations existed between the BMD values and diabetes duration, glycosylated hemoglobin (HbA1c) concentration, or age of diabetes onset. Similar results were obtained when applying stepwise multiple regression analysis to explain the BMD value variance. CONCLUSIONS: Young males with Type 1 diabetes exhibit significantly lower BMD values of trabecular and mixed cortical-trabecular bone, compared with matched healthy persons. Premenopausal females with Type 1 diabetes present significantly lower BMD values of mixed bone only. Blood glucose control and diabetes duration do not appear to influence BMD behavior.