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The most frequent hereditary hearing loss is caused by mutations in the GJB2 gene coding for the gap junction beta 2 protein Connexin 26 (Cx26). In contrast to many studies performed in patients with bi-allelic mutations, audiometric studies on heterozygotes are sparse and often contradictory. To evaluate hearing function in heterozygous carriers of the GJB2 c.35delG mutation, audiometry over the extended frequency range and the recording of otoacoustic emissions (OAEs), i.e., transient-evoked OAEs (TEOAEs) and distortion product OAEs (DPOAEs), were performed in a group of parents and grandparents of deaf children homozygous for the GJB2 c.35delG mutation. The comparison of audiograms between control and heterozygous subjects was enabled using audiogram normalization for age and sex. Hearing loss, estimated with this procedure, was found to be significantly larger in GJB2 c.35delG heterozygous females in comparison with controls for the frequencies of 8-16 kHz; the deterioration of hearing in heterozygous men in comparison with controls was not statistically significant. A comparison of TEOAE responses and DPOAE levels between GJB2 c.35delG heterozygotes and controls did not reveal any significant differences. The results prove the importance of using audiometry over the extended frequency range and audiogram normalization for age and sex to detect minor hearing impairments, even in a relatively small group of subjects of different ages.

MeSH
dospělí MeSH
genetická predispozice k nemoci genetika MeSH
genetické markery genetika MeSH
heterozygot * MeSH
incidence MeSH
jednonukleotidový polymorfismus genetika MeSH
konexiny genetika MeSH
lidé středního věku MeSH
lidé MeSH
mutace genetika MeSH
percepční nedoslýchavost diagnóza epidemiologie patofyziologie MeSH
rizikové faktory MeSH
senioři nad 80 let MeSH
senioři MeSH
sluchové testy statistika a číselné údaje MeSH
Check Tag
dospělí MeSH
lidé středního věku MeSH
lidé MeSH
mužské pohlaví MeSH
senioři nad 80 let MeSH
senioři MeSH
ženské pohlaví MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Geografické názvy
Česká republika MeSH

Abstrakt

Audiometrické nálezy u dětí léčených cisplatinou : XVIII. celostátní foniatrické dny Evy Sedláčkové a 5. česko-slovenský foniatrický kongres, Praha, 3.-5. října 2007 [abstrakt]

Novinky ve foniatrii a audiologii 2007. 2007 ; () : s. 68-69.

Medvik
Zdroj

Publikační typ
abstrakty MeSH

Článek

Changes in otoacoustic emissions and high-frequency hearing thresholds in children and adolescents

Hearing research. 2006 ; 212 (1-2 Feb) : 90-98.

Hear Res
ISSN 0378-5955
Medvik
Zdroj

With the aim of characterizing the loss of high frequency hearing sensitivity in children, hearing thresholds and otoacoustic emissions were measured in a group of 126 normal hearing children and adolescents aged from 6 to 25 years. The subjects were divided into four 5-year age groups. Hearing thresholds over a range of 125 Hz-12.5 kHz were similar in all age groups, the average hearing threshold at 16 kHz was significantly elevated in the oldest age group. The response values of transiently evoked otoacoustic emissions (TEOAEs) significantly declined with age; the decline was negatively correlated with the hearing loss at 16 kHz. Significantly larger TEOAE responses and average distortion-product otoacoustic emission (DPOAE) values at 6.3 kHz were present in the youngest group in comparison with the other three older groups. Spontaneous otoacoustic emissions (SOAEs) were present in 70.8% of the children (in either one or both ears) with the greatest prevalence in the 11-20-year-old subjects. In the 21-25-year-old group, the hearing loss at 16 kHz was significantly smaller in ears with SOAEs than in ears without SOAEs. The results demonstrate that the increase in the high frequency hearing threshold at 16 kHz, which starts at ages over 20 years, is correlated with a decrease in the TEOAE responses at middle frequencies.

MeSH
akustické impedanční testy MeSH
audiometrie čistými tóny MeSH
dítě MeSH
dospělí MeSH
financování organizované MeSH
kochlea fyziologie MeSH
lidé MeSH
mladiství MeSH
otoakustické emise spontánní fyziologie MeSH
otoskopie MeSH
sluchový práh fyziologie MeSH
věkové faktory MeSH
vnímání výšky zvuku fyziologie MeSH
vysokofrekvenční nedoslýchavost patofyziologie MeSH
Check Tag
dítě MeSH
dospělí MeSH
lidé MeSH
mladiství MeSH
mužské pohlaví MeSH
ženské pohlaví MeSH

Článek

Class IgG, IgM and IgA antibodies against Staphylococcus aureus antigens in human serum and saliva

Folia microbiologica. 1991 ; 36 (5) : 502-506.

Folia microbiol. (Prague)
ISSN 0015-5632 (tištěná verze)
Medvik
Zdroj

Using the ELISA method antibodies against the sonicate, teichoic acid (TA) and exoproducts of Staphylococcus aureus were determined in sera and saliva of healthy individuals. Main serum antibodies against all the antigens used were shown to be class IgG antibodies. However, antigens of the sonicate stimulated significantly even the systemic IgA response. In the saliva class IgA antibodies predominated, but IgG antibody levels against TA and exoproducts approached the level of IgA antibodies. Levels of IgM antibodies against all antigens tested were low in both the serum and saliva which corresponds with the anamnestic type of response. On the basis of these results one may assume that not only IgG, but also IgA antibodies are important in the systemic immunity against staphylococcal infection and in the immunity of mucous membranes; besides IgA, even class IgG antibodies play an important role.