• Klíčová slova
• imediátní implantace,
• MeSH
• fraktury zubů diagnostické zobrazování   terapie   MeSH
• implantace zubů * metody   MeSH
• lidé středního věku MeSH
• lidé MeSH
• počítačová tomografie s kuželovým svazkem MeSH
• stomatochirurgické výkony metody   MeSH
• terminologie jako téma MeSH
• zobrazování trojrozměrné MeSH
• Check Tag
• lidé středního věku MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

• MeSH
• kongresy jako téma MeSH

• MeSH
• kongresy jako téma MeSH
• prach prevence a kontrola   MeSH

• MeSH
• čelisti diagnostické zobrazování   patologie   MeSH
• implantace zubů metody   MeSH
• lidé MeSH
• parodontitida chirurgie   patologie   terapie   MeSH
• rekonstrukce mandibuly * metody   MeSH
• rentgendiagnostika panoramatická MeSH
• resorpce alveolární kosti chirurgie   terapie   MeSH
• senioři MeSH
• stomatochirurgické předprotetické výkony metody   MeSH
• stomatologická protetika metody   MeSH
• viklavost zubů chirurgie   terapie   MeSH
• zapojení pacienta MeSH
• ztráta parodontálního úponu * chirurgie   etiologie   MeSH
• Check Tag
• lidé MeSH
• senioři MeSH
• ženské pohlaví MeSH
• Publikační typ
• kazuistiky MeSH

During GABAergic synaptic transmission, G protein-coupled GABAB receptors (GBRs) activate K+ channels that prolong the duration of inhibitory postsynaptic potentials (IPSPs). We now show that KCTD16, an auxiliary GBR subunit, anchors hyperpolarization-activated cyclic nucleotide-gated (HCN) channels containing HCN2/HCN3 subunits to GBRs. In dopamine neurons of the VTA (DAVTA neurons), this interaction facilitates activation of HCN channels via hyperpolarization during IPSPs, counteracting the GBR-mediated late phase of these IPSPs. Consequently, disruption of the GBR/HCN complex in KCTD16-/- mice leads to prolonged optogenetic inhibition of DAVTA neuron firing. KCTD16-/- mice exhibit increased anxiety-like behavior in response to stress - a behavior replicated by CRISPR/Cas9-mediated KCTD16 ablation in DAVTA neurons or by intra-VTA infusion of an HCN antagonist in wild-type mice. Our findings support that the retention of HCN channels at GABAergic synapses by GBRs in DAVTA neurons provides a negative feedback mechanism that restricts IPSP duration and mitigates the development of anxiety.

• MeSH
• dopaminergní neurony * metabolismus   MeSH
• hyperpolarizační iontové kanály řízené cyklickými nukleotidy * metabolismus   genetika   MeSH
• inhibiční postsynaptické potenciály fyziologie   účinky léků   MeSH
• myši inbrední C57BL MeSH
• myši knockoutované MeSH
• myši MeSH
• receptory GABA-B * metabolismus   MeSH
• tegmentum mesencephali - area ventralis * metabolismus   MeSH
• úzkost * metabolismus   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Laboratory mice are the most commonly used animal model for Staphylococcus aureus infection studies. We have previously shown that laboratory mice from global vendors are frequently colonized with S. aureus. Laboratory mice originate from wild house mice. Hence, we investigated whether wild rodents, including house mice, as well as shrews are naturally colonized with S. aureus and whether S. aureus adapts to the wild animal host. 295 animals of ten different species were caught in different locations over four years (2012-2015) in Germany, France and the Czech Republic. 45 animals were positive for S. aureus (15.3%). Three animals were co-colonized with two different isolates, resulting in 48 S. aureus isolates in total. Positive animals were found in Germany and the Czech Republic in each studied year. The S. aureus isolates belonged to ten different spa types, which grouped into six lineages (clonal complex (CC) 49, CC88, CC130, CC1956, sequence type (ST) 890, ST3033). CC49 isolates were most abundant (17/48, 35.4%), followed by CC1956 (14/48, 29.2%) and ST890 (9/48, 18.8%). The wild animal isolates lacked certain properties that are common among human isolates, e.g., a phage-encoded immune evasion cluster, superantigen genes on mobile genetic elements and antibiotic resistance genes, which suggests long-term adaptation to the wild animal host. One CC130 isolate contained the mecC gene, implying wild rodents might be both reservoir and vector for methicillin-resistant . In conclusion, we demonstrated that wild rodents and shrews are naturally colonized with S. aureus, and that those S. aureus isolates show signs of host adaptation.

• MeSH
• antibakteriální látky farmakologie   MeSH
• bakteriální proteiny genetika   MeSH
• divoká zvířata mikrobiologie   MeSH
• faktory virulence genetika   MeSH
• hlodavci mikrobiologie   MeSH
• methicilin rezistentní Staphylococcus aureus MeSH
• mikrobiální testy citlivosti MeSH
• myši MeSH
• rejskovití mikrobiologie   MeSH
• stafylokokové infekce epidemiologie   veterinární   MeSH
• Staphylococcus aureus klasifikace   izolace a purifikace   MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH
• Francie MeSH
• Německo MeSH

BACKGROUND: Conduction system pacing (CSP), either as His bundle pacing (HBP) or as left bundle branch area pacing (LBBAP), may be superior to right ventricular apical or septal pacing. OBJECTIVE: The study sought to present acute results for a new guiding catheter (Biotronik Selectra 3D) designed for CSP implantations of a retractable screw-in lead (Biotronik Solia S). METHODS: The primary endpoint of the prospective, international nonrandomized BIO|MASTER.Selectra 3D study was freedom from catheter-related serious adverse device effects (SADEs) within 1 week of lead implantation. RESULTS: Of 157 enrolled patients, CSP was achieved in 147 (93.6%) patients. No SADEs occurred within 7 days. LBBAP was achieved in 82 patients (45 as crossover from an HBP attempt) and HBP in 65 (44.2%) patients. In centers considering both HBP and LBBAP, the CSP implantation success approached 99%. Successful CSP implantations lasted on average ∼50 minutes (fluoroscopy ∼6 minutes). Most procedures (87.9%) needed only 1 catheter, even after switch from HBP to LBBAP. The catheter's handling was rated largely positive. In patients without bundle branch block, mean QRS duration increased from 106 ms (intrinsic) to 122 ms (CSP) (P = .001). In patients with bundle branch block, mean QRS duration decreased from 151 ms (intrinsic) to 137 ms (CSP) (P = .004). CONCLUSION: The Selectra 3D catheter is a valuable tool for HBP and LBBAP implantations of the stylet-supported pacemaker leads. When implanters considered both HBP and LBBAP, the success rate was ∼99%. Flexibility to change between different approaches may be advisable in heterogeneous and challenging areas, such as CSP implantations.

• Publikační typ
• časopisecké články MeSH

Bohatě ilustrovaný svazek shrnuje veškeré známé výtvarné dílo C. G. Junga – od kreseb přes knižní malby, obrazy až po dřevěné a kamenné sochy. Obrazy jsou doplněny úvodními studiemi, které se zaměřují na kořeny Jungova výtvarného projevu, na souvislosti s jeho teorií mandal, na Jungův profil jako umělce, sběratele i diváka. Nakladatelská anotace. Kráceno; Bohatě ilustrovaná publikace představuje celek výtvarného díla C. G. Junga, zakladatelské osobnosti analytické psychologie a pronikavého myslitele 20. století.

• MeSH
• malířství MeSH
• myšlení MeSH
• sochařství MeSH
• Publikační typ
• obrazové publikace MeSH

• Konspekt
• Výtvarné umění
• NLK Obory
• psychologie, klinická psychologie
• humanitní vědy a umění

• O autorovi
• Jung, Carl Gustav, 1875-1961 Autorita

AIMS: Over decades, left ventricular assist device (LVAD) technology has transitioned from less durable bulky pumps to smaller continuous-flow pumps which have substantially improved long-term outcomes and quality of life. Contemporary LVAD therapy is beleaguered by haemocompatibility-related adverse events including thrombosis, stroke and bleeding. A fully magnetically levitated pump, the HeartMate 3 (HM3, Abbott, USA) LVAD, has been shown to be superior to the older HeartMate II (HMII, Abbott, USA) pump by improving haemocompatibility. Experience with the HM3 LVAD suggests near elimination of de-novo pump thrombosis, a marked reduction in stroke rates, and only a modest decrease in bleeding complications. Since the advent of continuous-flow LVAD therapy, patients have been prescribed a combination of aspirin and anticoagulation therapy on the presumption that platelet activation and perturbations to the haemostatic axis determine their necessity. Observational studies in patients implanted with the HM3 LVAD who suffer bleeding have suggested a signal of reduced subsequent bleeding events with withdrawal of aspirin. The notion of whether antiplatelet therapy can be avoided in an effort to reduce bleeding complications has now been advanced. METHODS: To evaluate this hypothesis and its clinical benefits, the Antiplatelet Removal and Hemocompatibility Events with the HeartMate 3 Pump (ARIES HM3) has been introduced as the first-ever international prospective, randomized, double-blind and placebo-controlled, non-inferiority trial in a patient population implanted with a LVAD. CONCLUSION: This paper reviews the biological and clinical role of aspirin (100 mg) with LVADs and discusses the rationale and design of the ARIES HM3 trial.

• MeSH
• Aspirin MeSH
• kvalita života MeSH
• lidé MeSH
• podpůrné srdeční systémy * MeSH
• prospektivní studie MeSH
• randomizované kontrolované studie jako téma MeSH
• srdeční selhání * terapie   MeSH
• Check Tag
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• přehledy MeSH

• Publikační typ
• abstrakt z konference MeSH