• MeSH
• Cluster Headache diagnosis   etiology   MeSH
• Diagnosis, Differential * MeSH
• Epidemiologic Factors MeSH
• Clinical Laboratory Techniques MeSH
• Humans MeSH
• Migraine Disorders diagnosis   etiology   MeSH
• Tomography, X-Ray Computed MeSH
• Headache Disorders, Primary * classification   MeSH
• Headache Disorders, Secondary * diagnosis   etiology   classification   MeSH
• Check Tag
• Humans MeSH

Colloidal clusters of magnetic iron oxide nanocrystals (MIONs), particularly in the condensed pattern (co-CNCs), have emerged as new superstructures to improve further the performance of MIONs in applications pertaining to magnetic manipulation (drug delivery) and magnetic resonance imaging (MRI). Exploitation of the advantages they represent and their establishment in the area of nanomedicine demands a particular set of assets. The present work describes the development and evaluation of MION-based co-CNCs featuring for the first time such assets: High magnetization, as well as magnetic content and moment, high relaxivities (r2 = 400 and r2* = 905 s(-1) mMFe(-1)) and intrinsic loss power (2.3 nH m(2) kgFe(-1)) are combined with unprecedented colloidal stability and structural integrity, stealth and drug-loading properties. The reported nanoconstructs are endowed with additional important features such as cost-effective synthesis and storage, prolonged self-life and biocompatibility. It is finally showcased with in vivo multispectral optoacoustic tomography how these properties culminate in a system suitable for targeting breast cancer and for forceful in vivo manipulation with low magnetic field gradients.

• MeSH
• Doxorubicin administration & dosage   MeSH
• Drug Delivery Systems MeSH
• Magnets chemistry   MeSH
• Mice, Nude MeSH
• Mice MeSH
• Breast Neoplasms pathology   MeSH
• Nanoparticles analysis   chemistry   MeSH
• Photoacoustic Techniques methods   MeSH
• Tomography, X-Ray Computed methods   MeSH
• Polyethylene Glycols chemistry   pharmacokinetics   MeSH
• Antibiotics, Antineoplastic administration & dosage   MeSH
• Breast pathology   MeSH
• Ferric Compounds chemistry   pharmacokinetics   MeSH
• Animals MeSH
• Check Tag
• Mice MeSH
• Female MeSH
• Animals MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

Přehledové sdělení se věnuje diagnostickému zobrazení akutních aortálních syndromů s důrazem na multidetektorovou výpočetní tomografii a na její význam pro volbu léčby. Diskutovány jsou jednak techniky CT zobrazení včetně CT s EKG synchronizací a dále diagnostické nálezy u disekce aorty, intramurálního hematomu a penetrujícího vředu aorty. Literární data jsou konfrontována s vlastními zkušenostmi terciárního centra v populaci městského typu.

Review payes attention to the importace of the diagnostic imaging in acute aortic syndromes concerning to the multidetector-row computed tomography and its impact on treatment decisions. The several CT techniques including CT with ECG synchronized acquisitions are discussed as well as the diagnostic findings of aortic dissection, intramural hematoma and penetrating aortic ulcer. Bibliographic data are faced with the own experience of the tertiary centre with urban population.

• Keywords
• MDCT, endovaskulární terapie, intramurální hematom,
• MeSH
• Acute Aortic Syndrome MeSH
• Acute Disease MeSH
• Angiography utilization   MeSH
• Artifacts MeSH
• Chest Pain diagnosis   pathology   MeSH
• Diagnostic Techniques, Cardiovascular utilization   MeSH
• Diagnosis, Differential * MeSH
• Aortic Dissection MeSH
• Endovascular Procedures MeSH
• Hematoma MeSH
• Incidence MeSH
• Contrast Media diagnostic use   MeSH
• Humans MeSH
• Multidetector Computed Tomography utilization   MeSH
• Aortic Diseases * diagnosis   MeSH
• Tomography, X-Ray Computed utilization   MeSH
• Aortic Rupture MeSH
• Statistics as Topic MeSH
• Syndrome MeSH
• Vascular Surgical Procedures MeSH
• Check Tag
• Humans MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH
• Review MeSH

Úvod: Tato práce prezentuje výsledky optimalizace rekonstrukčních parametrů, konkrétně počet iterací a počet subsetů OSEM algoritmu. Materiál a metody: Optimalizace byla založena na měření kontrastu a poměru signálu k šumu na tomografických rekonstrukcích NEMA Body Fantomu. Byla provedena akvizice čtyř sad projekčních dat se dvěma různými objemovými aktivitami na dvou různých kamerách. Pro nalezení optimálních hodnot byl proskenován parametrický prostor s použitím více než 500 rekonstrukcí s různými korekcemi a resolution recovery algoritmem (RR). Výsledky a závěr: S přihlédnutím k výpočetnímu času a opakované nestabilitě software byly jako nejlepší kombinace vyhodnoceny 4 iterace a 10 subsetů bez RR a 5 iterací a 10 subsetů s RR v matici 128 x 128, 3 iterace a 12 subsetů bez RR a 4 iterace a 12 subsetů s RR v matici 256 x 256.

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• Keywords
• optimalizace rekonstrukčníchparametrů pro SPECT a SPECT/CT,
• MeSH
• Algorithms MeSH
• Artifacts MeSH
• Phantoms, Imaging standards   utilization   MeSH
• Tomography, Emission-Computed, Single-Photon * methods   instrumentation   utilization   MeSH
• Humans MeSH
• Tomography, X-Ray Computed * methods   instrumentation   utilization   MeSH
• Computing Methodologies MeSH
• Image Processing, Computer-Assisted methods   utilization   MeSH
• Statistics as Topic MeSH
• Software Validation * MeSH
• Image Enhancement methods   standards   MeSH
• Check Tag
• Humans MeSH

Diverse isotopes such as 2H, 3He, 10Be, 11C and 14C occur in nuclear reactions in ion beam radiotherapy, in cosmic ray shielding, or are intentionally accelerated in dating techniques. However, only a few studies have specifically addressed the biological effects of diverse isotopes and were limited to energies of several MeV/u. A database of simulations with the PARTRAC biophysical tool is presented for H, He, Li, Be, B and C isotopes at energies from 0.5 GeV/u down to stopping. The doses deposited to a cell nucleus and also the yields per unit dose of single- and double-strand breaks and their clusters induced in cellular DNA are predicted to vary among diverse isotopes of the same element at energies < 1 MeV/u, especially for isotopes of H and He. The results may affect the risk estimates for astronauts in deep space missions or the models of biological effectiveness of ion beams and indicate that radiation protection in 14C or 10Be dating techniques may be based on knowledge gathered with 12C or 9Be.

• MeSH
• DNA MeSH
• Ions MeSH
• Isotopes * MeSH
• Monte Carlo Method MeSH
• DNA Damage * MeSH
• Publication type
• Journal Article MeSH

• MeSH
• Allergy and Immunology MeSH
• Immune System MeSH
• Publication type
• Textbook MeSH

• Conspectus
• Patologie. Klinická medicína
• Učební osnovy. Vyučovací předměty. Učebnice
• NML Fields
• alergologie a imunologie