There is substantial evidence for assortative partner preferences in humans based on physical characteristics. In contrast, evidence suggests that olfactory preferences tend to be disassortative, with people preferring body odour of potential partners who are dissimilar at key genetic loci, perhaps to gain fitness advantage through offspring heterozygosity. We compared ratings of perceived body odour similarity of real couples with those of randomly paired 'fake' couples. Contrary to prediction, we find that odours of real partners are perceived more, rather than less, similar to each other than fake couples. However, this applied only to natural odour samples: there were no differences in similarity levels of real and fake couples' samples which were collected while wearing artificial fragrances. Furthermore, in light of suggestions that hormonal contraception (HC) disrupts disassortative odour preferences in women, we compared odour similarity among real couples in which the female partner was using or not using HC at the time when the relationship began. We find that odours of HC-using couples are of intermediate similarity between non-using and fake couples, suggesting that HC use during partner choice could affect odour-influenced assortment. We also examined the association between relationship satisfaction and perceived similarity of unfragranced odours of real couples. We found that these are positively correlated in male partners but negatively correlated in the female partners, indicative of a sex difference in the relative favourability of odour similarity in partner preference. Finally, by comparing odour similarity ratings with those given by perfumers using a novel olfactory lexicon we found evidence that similarity judgements were based on the Spicy/Animalic aspects of individual odour profiles. Taken together, our results challenge the conventional view that odour-mediated partner preferences in humans are typically disassortative.

• MeSH
• demografie MeSH
• dospělí MeSH
• kontraceptiva orální hormonální farmakologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• odoranty * MeSH
• parfém * MeSH
• pohlavní dimorfismus MeSH
• sexuální chování účinky léků   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

The search for mates is often accompanied with conspicuous behaviour or morphology that can be exploited by predators. Here we explore the evolutionary consequences of a trade-off that arises naturally between mate acquisition and risk of predation and study evolution of the rate at which male prey search for mates in a population subject to a mate-finding Allee effect and exposed to either generalist or specialist predators. Since we show that the mate search rate determines the strength of the mate-finding Allee effect, we can alternatively view this as evolution of the mate-finding Allee effect in prey. We contrast two different life histories and find that, predominantly, male prey either evolve towards the maximal mate search rate yielding the weakest possible mate-finding Allee effect (thus showing no adaptive response in mating behaviour to predation risk) or evolutionary bi-stability occurs. In the latter case, males evolve a relatively low mate search rate (hence a relatively strong mate-finding Allee effect, interpreted as an adaptive response of male prey to predation) when initially slow or the maximal mate search rate when initially fast. Disruptive selection does not occur in populations exposed to generalist predators but is possible when predators are specialists. The dimorphic phase, in which fast and conspicuous male prey coexist with slow and cryptic ones, is however but a transient in evolutionary dynamics as one branch goes extinct while the other evolves towards the maximal mate search rate.

• MeSH
• algoritmy MeSH
• biologická evoluce * MeSH
• biologické modely MeSH
• kompetitivní chování fyziologie   MeSH
• predátorské chování fyziologie   MeSH
• rozmnožování fyziologie   MeSH
• sexuální chování zvířat fyziologie   MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

RATIONALE: Alcohol can disrupt conditioned sexual inhibition (CSI) established by first-order conditioning in male rats. CSI can also be induced using second-order conditioning, during which male rats are trained to associate a neutral odor with a nonreceptive female. As a result, when given access to two receptive females (one scented and one unscented) during a copulatory preference test, they display CSI toward the scented female. OBJECTIVE: The present study examined the effect of low-to-moderate doses of alcohol on CSI and brain activation following exposure to alcohol and the olfactory cue alone. METHODS: Sexually-naïve Long-Evans rats received alternate conditioning sessions with unscented receptive or scented (almond extract) non-receptive females. Following the conditioning phase, males were injected with saline, alcohol 0.5 g/kg or 1 g/kg, 45 min before a copulatory test with two receptive females, with one bearing the olfactory cue. Fos activation was later assessed, following exposure to alcohol and the olfactory cue alone, in several brain regions involved in the expression and regulation of male sexual behavior. RESULTS: While males in the saline group displayed sexual avoidance towards the scented female, those injected with alcohol before the copulatory test, regardless of the dose, copulated indiscriminately with both females. Subsequent exposure to alcohol and the olfactory cue alone induced different Fos expression between groups in several brain regions. CONCLUSIONS: Low to moderate doses of alcohol disrupt conditioned sexual inhibition in male rats and induce a differential pattern of neural activation, particularly in regions involved in the expression and regulation of sexual behavior.

• MeSH
• ethanol * farmakologie   aplikace a dávkování   MeSH
• inhibice (psychologie) MeSH
• krysa rodu rattus MeSH
• látky tlumící činnost CNS farmakologie   aplikace a dávkování   MeSH
• mozek účinky léků   metabolismus   MeSH
• podmiňování (psychologie) účinky léků   MeSH
• podněty MeSH
• potkani Long-Evans * MeSH
• protoonkogenní proteiny c-fos metabolismus   MeSH
• sexuální chování zvířat * účinky léků   MeSH
• vztah mezi dávkou a účinkem léčiva MeSH
• zvířata MeSH
• Check Tag
• krysa rodu rattus MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Light pollution is increasing worldwide and significantly affects animal behavior. In birds, these effects include advancement of morning activity and onset of dawn song, which may affect extra-pair paternity. Advanced dawn song of males may stimulate females to engage in extra-pair copulations, and the earlier activity onset may affect the males' mate guarding behavior. Earlier work showed an effect of light at night on extra-pair behavior, but this was in an area with other anthropogenic disturbances. Here, we present a two-year experimental study on effects of light at night on extra-pair paternity of great tits (Parus major). Previously dark natural areas were illuminated with white, red, and green LED lamps and compared to a dark control. In 2014, the proportion of extra-pair young in broods increased with distance to the red and white lamps (i.e., at lower light intensities), but decreased with distance to the poles in the dark control. In 2013, we found no effects on the proportion of extra-pair young. The total number of offspring sired by a male was unaffected by artificial light at night in both years, suggesting that potential changes in female fidelity in pairs breeding close to white and red light did not translate into fitness benefits for the males of these pairs. Artificial light at night might disrupt the natural patterns of extra-pair paternity, possibly negates potential benefits of extra-pair copulations and thus could alter sexual selection processes in wild birds.

• MeSH
• barva * MeSH
• osvětlení škodlivé účinky   MeSH
• Passeriformes fyziologie   MeSH
• sexuální chování zvířat účinky záření   MeSH
• světlo škodlivé účinky   MeSH
• vystavení vlivu životního prostředí MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH
• Research Support, U.S. Gov't, Non-P.H.S. MeSH

Sexual selection plays a key role in the diversification of numerous animal clades and may accelerate trait divergence during speciation. However, much of our understanding of this process comes from phylogenetic comparative studies, which rely on surrogate measures such as dimorphism that may not represent selection in wild populations. In this study, we assess sexual selection pressures for multiple male visual signals across four barn swallow (Hirundo rustica) populations. Our sample encompassed 2400 linear km and two described subspecies: European H. r. rustica (in the Czech Republic and Romania) and eastern Mediterranean H. r. transitiva (in Israel), as well as a potential area of contact (in Turkey). We demonstrate significant phenotypic differentiation in four sexual signalling axes, despite very low-level genomic divergence and no comparable divergence in an ecological trait. Moreover, the direction of phenotypic divergence is consistent with differences in sexual selection pressures among subspecies. Thus, H. r. transitiva, which have the darkest ventral plumage of any population, experience directional selection for darker plumage. Similarly, H. r. rustica, which have the longest tail feathers of any population, experience directional selection for elongated tail feathers and disruptive selection for ventral plumage saturation. These results suggest that sexual selection is the primary driver of phenotypic differentiation in this species. Our findings add to growing evidence of phenotypic divergence with gene flow. However, to our knowledge, this is the first study to relate direct measures of the strength and targets of sexual selection to phenotypic divergence among closely related wild populations.

• MeSH
• fenotyp MeSH
• fylogeneze * MeSH
• sexuální výběr u zvířat * MeSH
• tok genů * MeSH
• vlaštovkovití * MeSH
• zvířata MeSH
• Check Tag
• mužské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• Geografické názvy
• Česká republika MeSH
• Izrael MeSH
• Rumunsko MeSH

Consanguineous families have often played a role in the discovery of novel genes, especially in paediatric endocrinology. At this time, it has been estimated that over 8.5% of all children worldwide have consanguineous parents. Consanguinity is linked to demographic, cultural, and religious practises and is more common in some areas around the world than others. In children with endocrine conditions from consanguineous families, there is a greater probability that a single-gene condition with autosomal recessive inheritance is causative. From 1966 and the first description of Laron syndrome, through the discovery of the first KATP channel genes ABCC8 and KCNJ11 causing congenital hyperinsulinism (CHI) in the 1990s, to recent discoveries of mutations in YIPF5 as the first cause of monogenic diabetes due to the disruption of the endoplasmic reticulum (ER)-to-Golgi trafficking in the β-cell and increased ER stress; positive genetic findings in children from consanguinity have been important in elucidating novel genes and mechanisms of disease, thereby expanding knowledge into disease pathophysiology. The aim of this narrative review was to shed light on the lessons learned from consanguineous pedigrees with the help of 3 fundamental endocrine conditions that represent an evolving spectrum of pathophysiological complexity - from CHI, a typically single-cell condition, to monogenic diabetes which presents with uniform biochemical parameters (hyperglycaemia and glycosuria), despite varying aetiologies, up to the genetic regulation of human growth - the most complex developmental phenomenon.

• MeSH
• diabetes mellitus * genetika   MeSH
• dítě MeSH
• KATP kanály genetika   MeSH
• lidé MeSH
• mutace MeSH
• nanismus * MeSH
• pokrevní příbuzenství MeSH
• vrozený hyperinzulinismus * genetika   MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• přehledy MeSH

Mate choice in humans is specific by the involvement of kin both in partner choice and in the functioning of the relationship. The influence of relatives ranges from providing advice all the way to arranged marriages. Existing research so far tended to map neither the actual parental interventions and further reactions (counteractions) nor the independently pursued behavior (actions) by which the offspring or their partners assert their interests. This study identified such sets of behaviors through semi-structured individual interviews with members of 20 dyads of adult offspring and their biological parents (five son-mother, five son-father, five daughter-mother, and five daughter-father dyads). Thematic analysis revealed sets of parental actions aimed at the offspring, their partners, and the couple as a whole, as well as further counteractions (reactions to parental interference) and independently pursued behavior (actions) of the offspring and their partners aimed at the parents in the context of the offspring's previous or current relationship. Our findings showed that parental interference differed depending on the recipient: toward the couple were applied mainly indirect and supportive parental actions, whereas when facing their offspring or offspring's partner, parents' actions were more direct and disruptive. Our results thus indicate the importance of reporting about actual interactions which differ from the hypothetical settings used in prior studies by lower intensity. Moreover, by interviewing both members of dyads, we expanded the sets of actions and counteractions identified by prior studies and managed to limit self-reporting bias.

• MeSH
• dospělí MeSH
• lidé MeSH
• matky * MeSH
• rodiče * MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• ženské pohlaví MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

• MeSH
• behaviorální výzkum metody   MeSH
• charakteristiky rodiny dějiny   MeSH
• dítě MeSH
• financování organizované MeSH
• lidé MeSH
• manželství dějiny   trendy   MeSH
• poradenství metody   využití   MeSH
• rozvod psychologie   trendy   MeSH
• sociální problémy MeSH
• socioekonomické faktory dějiny   MeSH
• statistika jako téma MeSH
• výzkumný projekt MeSH
• zaměstnanost MeSH
• životní styl MeSH
• Check Tag
• dítě MeSH
• lidé MeSH
• Geografické názvy
• Česká republika MeSH

We investigated the regulation of hepatic ER stress in healthy liver and adult or perinatally programmed diet-induced non-alcoholic fatty liver disease (NAFLD). Female mice were fed either obesogenic or control diet before mating, during pregnancy and lactation. Post-weaning, offspring from each maternal group were divided into either obesogenic or control diet. At six months, offspring were sacrificed at 4-h intervals over 24 h. Offspring fed obesogenic diets developed NAFLD phenotype, and the combination of maternal and offspring obesogenic diets exacerbated this phenotype. UPR signalling pathways (IREα, PERK, ATF6) and their downstream regulators showed different basal rhythmicity, which was modified in offspring exposed to obesogenic diet and maternal programming. The double obesogenic hit increased liver apoptosis measured by TUNEL staining, active caspase-3 and phospho-JNK and GRP78 promoter methylation levels. This study demonstrates that hepatic UPR is rhythmically activated. The combination of maternal obesity (MO) and obesogenic diets in offspring triggered altered UPR rhythmicity, DNA methylation and cellular apoptosis.

• MeSH
• dieta s vysokým obsahem tuků škodlivé účinky   MeSH
• endoplazmatické retikulum fyziologie   MeSH
• fyziologický stres účinky léků   MeSH
• homeostáza MeSH
• játra účinky léků   MeSH
• krmivo pro zvířata analýza   MeSH
• myši inbrední C57BL MeSH
• myši MeSH
• obezita chemicky indukované   metabolismus   MeSH
• těhotenství MeSH
• zpožděný efekt prenatální expozice MeSH
• zvířata MeSH
• Check Tag
• myši MeSH
• těhotenství MeSH
• ženské pohlaví MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH

Juvenile hormone (JH), a sesquiterpenoid produced by the insect corpus allatum gland (CA), prevents metamorphosis in larvae and stimulates vitellogenesis in adult females. Whether the same JH signaling pathway regulates both processes is presently unknown. Here, we employ the robust JH response during reproduction and development of the linden bug, Pyrrhocoris apterus, to compare the function of key JH-signaling genes encoding the JH receptor, Methoprene-tolerant (Met), its binding partner Taiman (Tai), and a JH-inducible protein, Krüppel-homolog 1 (Kr-h1). RNA interference (RNAi) with Met or Tai, but not Kr-h1, blocked ovarian development and suppressed vitellogenin gene expression in the fat body of females raised under reproduction-inducing conditions. Loss of Met and Tai matched the effects of CA ablation or the natural absence of JH during reproductive diapause. Stimulation of vitellogenesis by treatment of diapausing females with a JH mimic methoprene also required both Met and Tai in the fat body, whereas Kr-h1 RNAi had no effect. Therefore, the Met-Tai complex likely functions as a JH receptor during vitellogenesis. In contrast to Met and Kr-h1 that are both required for JH to prevent precocious metamorphosis in P. apterus larvae, removal of Tai disrupted larval ecdysis without causing premature adult development. Our results show that while Met operates during metamorphosis in larvae and reproduction in adult females, its partner Tai is only required for the latter. The diverse functions of JH thus likely rely on a common receptor whose actions are modulated by distinct components.

• MeSH
• diapauza hmyzu MeSH
• Heteroptera růst a vývoj   metabolismus   fyziologie   MeSH
• juvenilní hormony metabolismus   MeSH
• larva růst a vývoj   metabolismus   fyziologie   MeSH
• rozmnožování MeSH
• sexuální chování zvířat MeSH
• shazování tělního pokryvu MeSH
• signální transdukce MeSH
• zvířata MeSH
• Check Tag
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH