Cíl práce: Stanovit korelaci mezi hodnotami MUCP (maximal urethral closure pressure) a sestupem uretry u žen s urodynamicky potvrzenou stresovou inkontinencí moči v rámci předoperačního vyšetření. Typ studie: Retrospektivní analýza. Název a sídlo pracoviště: Gynekologicko-porodnická klinika VFN a 1. LF UK, Praha. Soubor a metodika: Tato studie zahrnuje 567 pacientek ze tří prospektivních studií z let 2002 až 2009. Ultrazvukové měření bylo provedeno u 560 z nich a MUCP změřeno u 507 pacientek. MUCP byl definován jako rozdíl mezi maximálním uzavíracím tlakem a intravezikálním tlakem. Ultrazvukové měření bylo provedeno transperineálně podle doporučení ICS/IUGA. Sestup uretry byl vyjádřen jako vzdálenost mezi uložením uretry v klidu a při maximálním Valsalvově manévru. Data byla sumarizována jako průměr nebo medián, s SD a rozpětím quantilů pro měření variability. Statistické vyhodnocení bylo provedeno párovým t-testem nebo Wilcoxonovým testem. Výsledky: Průměrný MUCP byl 47,4 cm H2O (SD 22,2, první quantile 32, třetí quantile 62). Průměrný sestup uretry byl 20,6 mm (SD 8,2, první quantile 14,9, třetí quantile 25,6 mm). Při použití regresní analýzy jsme prokázali závislost hodnoty MUCP a sestupu uretry, při zvýšení MUCP o 10 cm H2O se zvyšuje sestup uretry o 1,1 mm. Závěr: Prokázali jsme statisticky významnou závislost mezi hodnotou MUCP a sestupem uretry. Zjištěné rozdíly nejsou klinicky významné, především pro hodnoty MUCP vyšší než 20 cm. Při MUCP méně než 20 cm H2O je vyšší pravděpodobnost zjištění nízké mobility uretry. Klinické využití MUCP jako prediktoru sestupu uretry je významně limitované pro vysokou variabilitu sestupu uretry pro stejné hodnoty MUCP.

Objective: Is it possible to estimate urethral mobility based on MUCP measurements? Design: Retrospective study. Setting: Department of Gynecology and Obstetrics, 1st Medical Faculty, Charles University, General Teaching Hospital, Prague. Methods: This retrospective study included 567 patients from three prospective studies within years 2002 to 2009. Ultrasound examination was performed in 560 of them and maximal urethral closure pressure (MUCP) values were measured in 507 women. The MUCP was defined as the difference between maximum urethral pressure and bladder pressure. An ultrasound examination was performed using the transperineal approach in accordance with the recommendations of the German Urogynecology Working Group and ICS, IUGA terminology. The mobility was expressed as a distance between the position at rest and at the maximal Valsalva manoeuvre. Data were summarized as mean and median, with SD and quantile range for measures of variability. Either a matched pairs t-test or Wilcoxon test was used for statistical evaluation. Results: Mean MUCP was 47.4 cm H2O (SD 22.2, first quantile 32, third quantile 62). Mean urethral descent was 20.6 mm (SD 8.2, first quantile 14.9, third quantile 25.6 mm). Using regression analysis there was an increase in urethral descent; this difference is statistically significant. For a MUCP increase of 10 cm H2O we could estimate an increase in urethral descent of 1.1 mm. Conclusion: We established a statistically significant relationship between urethral descent and MUCP. Unfortunately those differences are not clinically relevant, especially for MUCP over 20 cm H2O. For MUCP below 20 cm H2O low urethral descent is more likely. Clinical use of MUCP as predictor of urethral descent is limited due to the high variability involved.

• Keywords
• maximální uzavírací uretrální tlak, sestup uretry, urodynamické vyšetření,
• MeSH
• Humans MeSH
• Retrospective Studies MeSH
• Urinary Incontinence, Stress * physiopathology   MeSH
• Urethra physiopathology   MeSH
• Urodynamics MeSH
• Check Tag
• Humans MeSH
• Female MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

• Keywords
• systém R, R software,
• MeSH
• Electronic Data Processing MeSH
• Software MeSH
• Statistics as Topic MeSH
• Publication type
• Monograph MeSH
• Handbook MeSH

• Conspectus
• Kombinatorika. Teorie grafů. Matematická statistika. Operační výzkum. Matematické modelování
• NML Fields
• statistika, zdravotnická statistika

Mit dieser vollständig revidierten und erweiterten 8. Auflage der Wissenschaftlichen Tabellen Geigy soll fortgesetzt werden, was sich in langen Jahren bewährt hat: dem Naturwissenschaftler und insbesondere dem Arzt eine Zusammenstellung wissenschaftlicher, durch Literatur belegter Daten in gedrängter Form zu bieten, die ihn manch mühevoller Suche enthebt. Nakladatelská anotace. Kráceno

• MeSH
• Mathematical Concepts MeSH
• Mathematics MeSH
• Statistics as Topic MeSH
• Publication type
• Tables MeSH

• Conspectus
• Matematika
• NML Fields
• statistika, zdravotnická statistika

OBJECTIVES: Atopic dermatitis (AD) is a common allergic disease with potential links to environmental pollutants, including heavy metals. This study investigates the association between co-exposure to cadmium and mercury and AD among Korean children. METHODS: Data from the fourth cycle of the Korean National Environmental Health Survey (KoNEHS) included 736 elementary school students. Urinary cadmium and mercury levels were measured, and their association with lifetime prevalence of AD was analysed using logistic regression, weighted quantile sum (WQS) regression, quantile g-computation (QGC), and Bayesian kernel machine regression (BKMR). Confounders adjusted included age, sex, urinary cotinine, income, and body mass index. Sensitivity analyses used symptomatic AD and AD treatment as outcome variables. RESULTS: Among two metals, only cadmium in the highest tertile showed an odds ratio (OR) of 2.39 (95% CI: 1.12-5.10) compared with lowest tertile, with a significant trend per tertile increase (OR 1.58, 95% CI: 1.08-2.31) in multiple logistic regression. Co-exposure analysis using WQS and QGC revealed significant associations with AD prevalence, with WQS showing an OR of 1.47 (95% CI: 1.18-1.83) and QGC showing an OR of 1.60 (95% CI: 1.20-2.13) per tertile increase of exposure. BKMR indicated a dose-dependent relationship between overall exposure and AD risk. For symptomatic AD, similar trend was found. The treatment status of AD did not show a significant association with either heavy metal. CONCLUSION: This study suggests a significant association between co-exposure to cadmium and mercury and atopic dermatitis, emphasizing the need to consider combined environmental exposures in epidemiological studies.

• MeSH
• Dermatitis, Atopic * epidemiology   chemically induced   MeSH
• Child MeSH
• Cadmium * urine   adverse effects   MeSH
• Environmental Pollutants * urine   MeSH
• Humans MeSH
• Prevalence MeSH
• Mercury * urine   adverse effects   MeSH
• Students statistics & numerical data   MeSH
• Environmental Exposure * adverse effects   statistics & numerical data   analysis   MeSH
• Health Surveys MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Geographicals
• Republic of Korea MeSH

Although severe acute respiratory syndrome coronavirus 2 messenger ribonucleic acid (SARS-CoV-2 mRNA) vaccines are effective in kidney transplant recipients (KTRs), their immune response to vaccination is blunted by immunosuppression. Other tools enhancing vaccination response are therefore needed. Interestingly, aligning vaccine administration with circadian rhythms (chronovaccination) has been shown to boost immune response. However, its applicability in KTRs, whose circadian rhythms are likely disrupted by immunosuppressants, remains unclear. To assess the impact of vaccination timing on seroconversion in the KTRs population, we analyzed data from 553 virus-naïve KTRs who received 2 doses of messenger ribonucleic acid (mRNA) vaccine. Bayesian logistic regression was employed, adjusting for previously identified predictors of seroconversion, including allograft function, maintenance immunosuppressants, or time since transplantation. SARS-CoV-2 immunoglobulin G (IgG) levels were measured with a median of 47 days after the second dose. The results did not reveal a reliable effect of timing of the first dose but did indicate that earlier timing for the second dose brings a notable benefit-every 1-hour delay in the application was associated with a 16% reduction in the odds of seroconversion (OR 0.84, 95% CI 0.71, 0.998). Similar results were obtained from quantile regression modeling IgG levels. In conclusion, morning vaccination is emerging as a promising and easily implementable strategy to enhance vaccine response in KTRs.

• MeSH
• Kidney Failure, Chronic surgery   immunology   MeSH
• Circadian Rhythm immunology   MeSH
• COVID-19 * prevention & control   immunology   MeSH
• Adult MeSH
• Immunity, Humoral * MeSH
• Immunoglobulin G blood   immunology   MeSH
• Immunosuppressive Agents administration & dosage   therapeutic use   MeSH
• Middle Aged MeSH
• Humans MeSH
• Transplant Recipients MeSH
• Antibodies, Viral * blood   immunology   MeSH
• Graft Rejection immunology   prevention & control   MeSH
• SARS-CoV-2 * immunology   MeSH
• Aged MeSH
• Kidney Transplantation * MeSH
• Vaccination MeSH
• COVID-19 Vaccines * immunology   administration & dosage   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

RATIONALE: Forced expiratory volume in one second (FEV1), an important measure of pulmonary disease severity in patients with cystic fibrosis (CF), is frequently expressed as a percentage of a predicted value derived from a healthy reference population. There are limitations to comparing the lung function of a patient with CF to that of healthy control subjects, and potential advantages to comparing it to that of other patients with CF. OBJECTIVE: To estimate CF-specific percentiles of FEV1 as functions of height, age, and sex. METHODS: We used 287,108 FEV1 observations among more than 21,000 patients with CF in the CF Foundation National Patient Registry between 1994 and 2001. The percentiles were estimated using quantile regression methods. RESULTS: FEV1 percentile "growth grids" are presented, allowing comparison of an individual's FEV1 to that of patients with CF of the same sex, age, and height. Their potential uses in clinical practice and research are illustrated. CONCLUSIONS: CF-specific reference equations allow individual patients' FEV1 to be placed in the context of the distribution of lung function of their peers with CF, and should improve generalizability of CF clinical trials by setting entry criteria that are equitable across sex and age ranges. They may serve as a useful adjunct to conventional reference equations.

• MeSH
• Cystic Fibrosis physiopathology   MeSH
• Child MeSH
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Reference Values MeSH
• Sex Factors MeSH
• Forced Expiratory Volume MeSH
• Check Tag
• Child MeSH
• Adult MeSH
• Humans MeSH
• Adolescent MeSH
• Male MeSH
• Female MeSH

OBJECTIVES: Polychlorinated biphenyls (PCBs), a family of persistent toxic and organic environmental pollutants, were associated with multiple organ damages in humans once accumulating. However, association between PCBs exposure and circulatory immune markers were not clear. METHODS: Data was collected from participants enrolled in the National Health and Nutrition Examination Survey in 1999-2004. PCBs were categorized by latent class analysis (LCA). Weighted quantile sum (WQS) regression was used to investigate effects of PCBs exposure on circulatory immune markers including leukocyte counts, monocyte-lymphocyte ratio (MLR), neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). RESULTS: There were 3,109 participants included in the final analysis with blood PCBs levels presented as 3 classes. The high PCBs group had a higher rate of comorbidities. Leukocyte, lymphocyte and neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR) and system immune-inflammation index (SII) were significantly lower in the high PCBs group than in the low PCBs group (all p-values < 0.05). After adjusting for covariant variables, the low PCBs group was positively associated with SII (p = 0.021) and NLR (p = 0.006) in multivariate regression. Significantly negative correlations between PCBs classification and SII (β = -14.513, p = 0.047), and NLR (β = -0.035, p = 0.017) were found in WQS models. LBX028LA showed the most significant contribution in the associations between PCBs and SII, and LBX128LA contributed most significantly to associations with NLR. CONCLUSION: Our study adds novel evidence that exposures to PCBs may be adversely associated with the circulatory immune markers, indicating the potential toxic effect of PCBs on the human immune system.

• MeSH
• Biomarkers * blood   MeSH
• Adult MeSH
• Environmental Pollutants * blood   MeSH
• Middle Aged MeSH
• Humans MeSH
• Polychlorinated Biphenyls * blood   toxicity   MeSH
• Aged MeSH
• Environmental Exposure adverse effects   analysis   MeSH
• Nutrition Surveys * MeSH
• Inflammation blood   chemically induced   immunology   MeSH
• Check Tag
• Adult MeSH
• Middle Aged MeSH
• Humans MeSH
• Male MeSH
• Aged MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

• MeSH
• Statistics as Topic MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• statistika, zdravotnická statistika
• NML Publication type
• kolektivní monografie

• MeSH
• Environmental Monitoring methods   MeSH
• Data Collection MeSH
• Models, Theoretical MeSH
• Toxicity Tests MeSH
• Environmental Exposure MeSH

• Conspectus
• Lékařské vědy. Lékařství
• NML Fields
• environmentální vědy
• toxikologie
• management, organizace a řízení zdravotnictví
• environmentální vědy
• environmentální vědy
• farmacie a farmakologie
• veřejné zdravotnictví
• NML Publication type
• publikace WHO

INTRODUCTION: This study aimed to determine the effect and clinical impact of physiological characteristics on the 95th/5th centile of the umbilical artery (UA) Doppler and the cerebroplacental ratio (CPR), at 36+ weeks. METHODS: From the multicenter randomized trial "Ratio37," we selected 4,505 low-risk pregnant women between June 2016 and January 2020. We registered physiological characteristics and the pulsatility indexes (PI) of the UA and middle cerebral artery (36-39 weeks). The 95th/5th centile of the UA PI and CPR was modeled by quantile regression. To evaluate the clinical impact of adjusting Doppler, we retrospectively applied gestational age (GA) and fully adjusted standards to 682 small for gestational age (SGA)-suspected fetuses (37 weeks) from a cohort of consecutive patients obtained between January 2010 and January 2020. RESULTS: Several physiological characteristics significantly influenced the 95th/5th centile of the UA and CPR PI. The fully adjusted 95th centile of the UA was higher, and the 5th centile of the CPR was lower than GA-only-adjusted standards. Of the 682 SGA fetuses, 150 (22%) were classified as late fetal growth restricted only by GA and 112 (16.4%) when we adjusted Doppler. These 38 fetuses had similar perinatal outcome than the SGA group. DISCUSSION: The 95th/5th centile of the UA and CPR PI is significantly influenced by physiological characteristics. Adjusting Doppler standards could differentiate better between FGR and SGA.

• MeSH
• Middle Cerebral Artery diagnostic imaging   MeSH
• Umbilical Arteries diagnostic imaging   MeSH
• Gestational Age MeSH
• Infant, Small for Gestational Age MeSH
• Humans MeSH
• Infant, Newborn MeSH
• Placenta * diagnostic imaging   MeSH
• Fetus MeSH
• Pulsatile Flow MeSH
• Retrospective Studies MeSH
• Fetal Growth Retardation * diagnostic imaging   MeSH
• Pregnancy MeSH
• Ultrasonography, Doppler MeSH
• Ultrasonography, Prenatal MeSH
• Check Tag
• Humans MeSH
• Infant, Newborn MeSH
• Pregnancy MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Multicenter Study MeSH
• Randomized Controlled Trial MeSH