• MeSH
• Archives MeSH
• Video Recording MeSH
• Documentation MeSH
• Gynecologic Surgical Procedures MeSH
• Gynecology MeSH
• Software MeSH

• MeSH
• Biometry MeSH
• Electrocardiography MeSH
• Monitoring, Physiologic MeSH
• Heart Rate MeSH

• MeSH
• Autonomic Nervous System physiopathology   MeSH
• Electrocardiography methods   MeSH
• Humans MeSH
• Microcomputers MeSH
• Software MeSH
• Spectrum Analysis MeSH
• Heart Rate MeSH
• Telemetry methods   MeSH
• Check Tag
• Humans MeSH

R-loops are common non-B nucleic acid structures formed by a three-stranded nucleic acid composed of an RNA-DNA hybrid and a displaced single-stranded DNA (ssDNA) loop. Because the aberrant R-loop formation leads to increased mutagenesis, hyper-recombination, rearrangements, and transcription-replication collisions, it is regarded as important in human diseases. Therefore, its prevalence and distribution in genomes are studied intensively. However, in silico tools for R-loop prediction are limited, and therefore, we have developed the R-loop tracker tool, which was implemented as a part of the DNA Analyser web server. This new tool is focused upon (1) prediction of R-loops in genomic DNA without length and sequence limitations; (2) integration of R-loop tracker results with other tools for nucleic acids analyses, including Genome Browser; (3) internal cross-evaluation of in silico results with experimental data, where available; (4) easy export and correlation analyses with other genome features and markers; and (5) enhanced visualization outputs. Our new R-loop tracker tool is freely accessible on the web pages of DNA Analyser tools, and its implementation on the web-based server allows effective analyses not only for DNA segments but also for full chromosomes and genomes.

• MeSH
• Algorithms * MeSH
• DNA chemistry   genetics   MeSH
• Genomics methods   MeSH
• Internet statistics & numerical data   MeSH
• Humans MeSH
• Genomic Instability * MeSH
• R-Loop Structures * MeSH
• Software MeSH
• Check Tag
• Humans MeSH
• Publication type
• Journal Article MeSH

Příručka, která se zaměřuje na nelineární regresivní modely a software R k analýze biologických dat. Určeno odborné veřejnosti.; Odborná publikace zabývající se nelineárními modely analýzy biologických dat.

• MeSH
• Data Analysis MeSH
• Biology statistics & numerical data   MeSH
• Regression Analysis MeSH
• Software MeSH
• Publication type
• Handbook MeSH

• Conspectus
• Biologické vědy
• NML Fields
• statistika, zdravotnická statistika
• biologie

• MeSH
• Blood Glucose Self-Monitoring instrumentation   MeSH
• Software MeSH

Příspěvek pojednává některé aspekty využívání programů pro statistickou analýzu. Ukazuje se, že vedle tradičních programových systému jako SPSS nebo STATISTICA se stále více prosazuje systém R se svým programovacím jazykem. Tento systém má dvě hlavní výhody. Je volně šiřitelný stejně jako programové balíčky, které jsou v něm vytvářeny. Existuje již několik tisíc programových balíčku v jazyce R pro nejrůznější úkoly statistické analýzy. Pojednáváme základy systému R a některé rozšiřující programové balíčky.

The paper discusses some aspects of using statistical analysis programs. Besides traditional program systems such as SPSS or STATISTICA, rising popularity of R system with its own programming language has been seen. This system entails two principal advantages. It can be freely distributed, similarly as its program packages created in its environment. Currently, several thousand program packages in the R language exist for varied tasks of statistical analysis. This paper discusses the basics of the R system, as well as some extension program packages.

• Keywords
• systém R,
• MeSH
• Electronic Data Processing methods   MeSH
• Biomedical Research methods   MeSH
• Programming Languages MeSH
• Software MeSH
• Statistics as Topic MeSH

• Keywords
• softwarové inženýrství,
• MeSH
• Software MeSH

• Conspectus
• Programové vybavení. Programové prostředky
• NML Publication type
• monografie

Identification of metal-binding sites in proteins and understanding metal-coupled protein folding mechanisms are aspects of high importance for the structure-to-function relationship. Mass spectrometry (MS) has brought a powerful adjunct perspective to structural biology, obtaining from metal-to-protein stoichiometry to quaternary structure information. Currently, the different experimental and/or instrumental setups usually require the use of multiple data analysis software, and in some cases, they lack some of the main data analysis steps (MS processing, scoring, identification). Here, we present a comprehensive data analysis pipeline that addresses charge-state deconvolution, statistical scoring, and mass assignment for native MS, bottom-up, and native top-down with emphasis on metal-protein complexes. We have evaluated all of the approaches using assemblies of increasing complexity, including free and chemically labeled proteins, from low- to high-resolution MS. In all cases, the results have been compared with common software and proved how MetaOdysseus outperformed them.

• MeSH
• Cysteine * MeSH
• Mass Spectrometry MeSH
• Proteins * MeSH
• Software MeSH
• Binding Sites MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH