Higher-order chromatin structure in DSB induction, repair and misrepair
Language English Country Netherlands Media print-electronic
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
PubMed
20144732
DOI
10.1016/j.mrrev.2010.01.013
PII: S1383-5742(10)00017-7
Knihovny.cz E-resources
- MeSH
- Models, Biological MeSH
- Chromatin radiation effects ultrastructure MeSH
- DNA Breaks, Double-Stranded * MeSH
- Radiation, Ionizing * MeSH
- Humans MeSH
- DNA Repair * MeSH
- DNA Damage MeSH
- Translocation, Genetic MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
- Names of Substances
- Chromatin MeSH
Double-strand breaks (DSBs), continuously introduced into DNA by cell metabolism, ionizing radiation and some chemicals, are the biologically most deleterious type of genome damage, and must be accurately repaired to protect genomic integrity, ensure cell survival, and prevent carcinogenesis. Although a huge amount of information has been published on the molecular basis and biological significance of DSB repair, our understanding of DSB repair and its spatiotemporal arrangement is still incomplete. In particular, the role of higher-order chromatin structure in DSB induction and repair, movement of DSBs and the mechanism giving rise to chromatin exchanges, and many other currently disputed questions are discussed in this review. Finally, a model explaining the formation of chromosome translocations is proposed.
References provided by Crossref.org
Condensed Matter Systems Exposed to Radiation: Multiscale Theory, Simulations, and Experiment
Spatial-Temporal Genome Regulation in Stress-Response and Cell-Fate Change
In Vitro Comparison of Passive and Active Clinical Proton Beams
