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Záznam pochází z PubMed

Novel lipidized analogs of prolactin-releasing peptide have prolonged half-lives and exert anti-obesity effects after peripheral administration

Maletínská, L
Autor Maletínská, L Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic
Nagelová, V
Autor Nagelová, V Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic
Tichá, A
Autor Tichá, A Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic
Zemenová, J
Autor Zemenová, J ] Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic [2] Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic
Pirník, Z
Autor Pirník, Z ] Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic [2] Laboratory of Functional Neuromorphology, Institute of Experimental Endocrinology, SAS, Bratislava, Slovak Republic [3] Department of Human and Clinical Pharmacology, University of Veterinary Medicine, Košice, Slovak Republic
Holubová, M
Autor Holubová, M Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic
Špolcová, A
Autor Špolcová, A Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic
Mikulášková, B
Autor Mikulášková, B ] Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic [2] Institute of Physiology, AS CR, Prague, Czech Republic
Blechová, M
Autor Blechová, M Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic
Sýkora, D
Autor Sýkora, D Department of Analytical Chemistry, University of Chemistry and Technology, Prague, Czech Republic
Lacinová, Z
Autor Lacinová, Z Third Department of Medicine, Charles University in Prague, Prague, Czech Republic
Haluzík, M
Autor Haluzík, M Third Department of Medicine, Charles University in Prague, Prague, Czech Republic
Železná, B
Autor Železná, B Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic
Kuneš, J
Autor Kuneš, J ] Antiobesity Peptides, Institute of Organic Chemistry and Biochemistry, AS CR, Prague, Czech Republic [2] Institute of Physiology, AS CR, Prague, Czech Republic

International journal of obesity (2005). 2015 Jun ; 39 (6) : 986-93. [epub] 20150316

Int J Obes (Lond)
ISSN 1476-5497 | 0307-0565
Zdroj

Jazyk angličtina Země Anglie, Velká Británie Médium print-electronic

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz https://www.medvik.cz/link/pmid25771926

PubMed 25771926
DOI 10.1038/ijo.2015.28
PII: ijo201528
Knihovny.cz E-zdroje

MeSH
energetický metabolismus MeSH
hormon uvolňující prolaktin analogy a deriváty farmakologie MeSH
látky proti obezitě farmakologie MeSH
lipidy chemie MeSH
myši inbrední C57BL MeSH
myši MeSH
obezita prevence a kontrola MeSH
poločas MeSH
přijímání potravy MeSH
regulace chuti k jídlu MeSH
signální transdukce MeSH
zvířata MeSH
Check Tag
mužské pohlaví MeSH
myši MeSH
zvířata MeSH
Publikační typ
časopisecké články MeSH
práce podpořená grantem MeSH
Názvy látek
hormon uvolňující prolaktin MeSH
látky proti obezitě MeSH
lipidy MeSH

OBJECTIVES: Obesity is a frequent metabolic disorder but an effective therapy is still scarce. Anorexigenic neuropeptides produced and acting in the brain have the potential to decrease food intake and ameliorate obesity but are ineffective after peripheral application. We have designed lipidized analogs of prolactin-releasing peptide (PrRP), which is involved in energy balance regulation as demonstrated by obesity phenotypes of both PrRP- and PrRP-receptor-knockout mice. RESULTS: Lipidized PrRP analogs showed binding affinity and signaling in PrRP receptor-expressing cells similar to natural PrRP. Moreover, these analogs showed high binding affinity also to anorexigenic neuropeptide FF-2 receptor. Peripheral administration of myristoylated and palmitoylated PrRP analogs to fasted mice induced strong and long-lasting anorexigenic effects and neuronal activation in the brain areas involved in food intake regulation. Two-week-long subcutaneous administration of palmitoylated PrRP31 and myristoylated PrRP20 lowered food intake, body weight and improved metabolic parameters, and attenuated lipogenesis in mice with diet-induced obesity. CONCLUSIONS: Our data suggest that the lipidization of PrRP enhances stability and mediates its effect in central nervous system. Strong anorexigenic and body-weight-reducing effects make lipidized PrRP an attractive candidate for anti-obesity treatment.

] Antiobesity Peptides Institute of Organic Chemistry and Biochemistry AS CR Prague Czech Republic [2] Department of Analytical Chemistry University of Chemistry and Technology Prague Czech Republic

] Antiobesity Peptides Institute of Organic Chemistry and Biochemistry AS CR Prague Czech Republic [2] Institute of Physiology AS CR Prague Czech Republic

] Antiobesity Peptides Institute of Organic Chemistry and Biochemistry AS CR Prague Czech Republic [2] Laboratory of Functional Neuromorphology Institute of Experimental Endocrinology SAS Bratislava Slovak Republic [3] Department of Human and Clinical Pharmacology University of Veterinary Medicine Košice Slovak Republic

3rd Department of Medicine Charles University Prague Prague Czech Republic

Antiobesity Peptides Institute of Organic Chemistry and Biochemistry AS CR Prague Czech Republic

Department of Analytical Chemistry University of Chemistry and Technology Prague Czech Republic

Zobrazit více v PubMed

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