Incisional hernia affects up to 20% of patients after abdominal surgery. Unlike other types of hernia, its prognosis is poor, and patients suffer from recurrence within 10 years of the operation. Currently used hernia-repair meshes do not guarantee success, but only extend the recurrence-free period by about 5 years. Most of them are nonresorbable, and these implants can lead to many complications that are in some cases life-threatening. Electrospun nanofibers of various polymers have been used as tissue scaffolds and have been explored extensively in the last decade, due to their low cost and good biocompatibility. Their architecture mimics the natural extracellular matrix. We tested a biodegradable polyester poly-ε-caprolactone in the form of nanofibers as a scaffold for fascia healing in an abdominal closure-reinforcement model for prevention of incisional hernia formation. Both in vitro tests and an experiment on a rabbit model showed promising results.

• MeSH
• biomechanika MeSH
• břicho chirurgie   MeSH
• buňky 3T3 MeSH
• chirurgické síťky MeSH
• hernie prevence a kontrola   MeSH
• histocytochemie MeSH
• hojení ran účinky léků   MeSH
• králíci MeSH
• mezibuněčné signální peptidy a proteiny chemie   farmakologie   terapeutické užití   MeSH
• myši MeSH
• nanovlákna chemie   terapeutické užití   MeSH
• polyestery chemie   terapeutické užití   MeSH
• polypropyleny chemie   terapeutické užití   MeSH
• pooperační komplikace prevence a kontrola   MeSH
• řízená tkáňová regenerace MeSH
• techniky uzavření břišních poranění přístrojové vybavení   MeSH
• zvířata MeSH
• Check Tag
• králíci MeSH
• myši MeSH
• zvířata MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Well-differentiated thyroid carcinoma (WDTC) represents the most common endocrine malignancy. Despite excellent prognoses exceeding 90% in 10-year follow-up, there are clinically controversial issues. One of these is extrathyroidal tumour extension invading recurrent laryngeal nerve (RLN). The spread outside of the thyroid parenchyma and invasion to the surrounding structures, classified as always T4a, are the most important negative prognostic factor for the WDTC. Conversely, resection of the RLN leads to vocal cord paralysis with hoarseness, possible swallowing problems, and finally decreased quality of life. We propose a new algorithm for intraoperative management based on the MACIS classification, which would allow swift status evaluation pre/intraoperatively and consider a possibility to preserve the infiltrated RLN without compromising an oncological radicality. In the case of a preoperative vocal cord paralysis (VCP) and confirmation of the invasive carcinoma, a resection of the RLN and the nerve graft reconstruction are indicated. Preoperatively, unaffected vocal cord movement and intraoperatively detected RLN infiltration by the invasive WDTC require an individual assessment of the oncological risk by the proposed algorithm. Preservation of the infiltrated RLN is oncologically acceptable only in specific groups of patients of a younger age with a minor size of primary tumour.

• MeSH
• dospělí MeSH
• ezofágus patologie   MeSH
• kvalita života MeSH
• larynx patologie   MeSH
• lidé středního věku MeSH
• lidé MeSH
• nádory štítné žlázy metabolismus   patologie   chirurgie   MeSH
• nervus laryngeus recurrens metabolismus   patologie   MeSH
• ochrnutí hlasivek komplikace   patologie   MeSH
• trachea patologie   MeSH
• Check Tag
• dospělí MeSH
• lidé středního věku MeSH
• lidé MeSH
• Publikační typ
• časopisecké články MeSH
• práce podpořená grantem MeSH

Introduction: Scoliosis influences the optimal posture of the human body. The effect on the gait cycle of this entity is of major interesting. Purpose: Young adults with moderate idiopathic scoliosis (MIS) present kinematic modifications regarding the convex or concave side of the body compared to healthy people. Aim was to identify these variations. Methods: A cohort of twenty young adults (group A) having MIS and a control group (B) of fifteen healthy individuals were submitted in 3-D gait analysis with direct linear transformation method. The parameters examined were concerning the displacement of the knee and the ankle joints on x, y and z axes. The gait cycle and the knee range of motion were examined. Results: Gait cycle in scoliosis patients showed increased duration compared to healthy people, p<0,05. Regarding side to side comparison of the lower extremities in scoliosis patients the following outcomes were identified: Knee and ankle joint displacement in the ipsilateral (convex) side was increased regarding sagittal axis (x), p<0,05. When compared both groups the following differences found, p<0,05: The knee joint in the ipsilateral side (group A) had increased mean (z) frontal displacement. In the controlateral side (concave) of group A had decreased mean sagittal displacement and increased mean frontal and mean vertical (y) displacement. The ankle joint in the ipsilateral side had increased mean sagittal and frontal displacement. In the controlateral side had increased mean frontal displacement. The knee range of motion during the phases of gait cycle in scoliosis patients was seriously reduced compared to control group, p<0,05. Discussion: Asymmetries observed amongst the lower extremities during the gait cycle of scoliosis patients. Also asymmetries observed in comparison to healthy people. Some of these asymmetries agree to other studies. A compensatory walking close to normal walking existed. These observations might prove to be helpful in treating the gait cycle of young adults with MIS.

• Klíčová slova
• kolenní a hlezenní kloub,
• MeSH
• audiovizuální záznam MeSH
• biomechanika MeSH
• chůze (způsob) fyziologie   MeSH
• chůze * fyziologie   statistika a číselné údaje   MeSH
• dospělí MeSH
• fyziologická adaptace MeSH
• hlezenní kloub fyziologie   patofyziologie   MeSH
• kolenní kloub * fyziologie   patofyziologie   MeSH
• lidé MeSH
• mladý dospělý MeSH
• počítačové zpracování obrazu MeSH
• rozsah kloubních pohybů MeSH
• skolióza * komplikace   patofyziologie   MeSH
• statistika jako téma MeSH
• studie případů a kontrol MeSH
• zatížení muskuloskeletálního systému MeSH
• Check Tag
• dospělí MeSH
• lidé MeSH
• mladý dospělý MeSH
• mužské pohlaví MeSH
• ženské pohlaví MeSH