Cieľom práce bolo posúdiť význam hladiny solubilného receptora interleukínu 2 (sIL2R) a sérového enzýmu konvertujúceho angiotenzín (SACE) pre diagnostiku, hodnotenie štádia a rozsahu sarkoidózy a zhodnotenie ich korelácií s inými ukazovateľmi aktivity zápalu pri sarkoidóze, v čase diagnostiky a v časovom odstupe 6 mesiacov. Sledovaný súbor tvorilo 48 pacientov s histologicky overenou sarkoidózou. Vyšetrenie sIL2R i SACE sa pri diagnostike sarkoidózy ukázalo byť vhodným vyšetrením, pričom hodnoty senzitivity a špecificity boli pre sIL2R (70,8% vs. 100%) lepšie než pre SACE (56,3% vs. 91,3%). Bola zistená korelácia hodnôt oboch testov. Hladina SACE bola ovplyvnená vekom. V celom súbore pacientov došlo k signifikantnému poklesu hodnôt sIL2R a SACE po 6 mesiacoch od diagnostiky ochorenia. U pacientov s celkovou kortikoterapiou došlo k signifikantnému poklesu hladín sIL2R i SACE. U pacientov bez kortikoterapie bol výrazný, ale len hranične štatisticky významný pokles hladiny sIL2R (p=0,05).V skupine pacientov so stacionárnym rtg nálezom bez klinického zhoršenia došlo k signifikantnému poklesu hladiny sIL2R a v skupine pacientov s rtg regresiou došlo k signifikantnému poklesu hladín sIL2R i SACE. Získané výsledky by bolo možné vysvetliť vyššou citlivosťou a rychlejšou dynamikou hladiny sIL2R než SACE.
The work aimed at assessing the role of soluble interleukin-2 receptor (sIL2R) and serum angiotensin converting enzyme (SACE) levels in diagnosing and staging of sarcoidosis and evaluating its correlations with other inflammatory activity markers in sarcoidosis at diagnosis and after 6 months. The study group comprised 48 patients with histologically confirmed sarcoidosis. The measurement of both sIL2R and SACE proved useful for diagnosing sarcoidosis, with sensitivity and specificity values being higher in sIL2R (70.8 % and 100 %, respectively) than in SACE (56.3 % and 91.3 %, respectively). Correlation of results of the two tests was determined. SACE levels were influenced by the age. In the entire study group, the sIL2R and SACE levels were significantly lower at 6 months after diagnosis. In patients with general corticotherapy, both sIL2R and SACE levels decreased significantly. In patients without corticotherapy, the levels of sIL2R dropped markedly but the statistical significance was only borderline (p = 0.05). Patients with no changes in X-ray findings and no clinical deterioration showed statistically significantly lower slL2R whereas in patients with X-ray regression, both sIL2R and SACE levels decreased significantly. The results could be explained by higher sensitivity and more rapid dynamics of the sIL2R level when compared to SACE.
- MeSH
- Peptidyl-Dipeptidase A diagnostic use MeSH
- Interleukin-2 diagnostic use MeSH
- Humans MeSH
- Sarcoidosis diagnosis epidemiology immunology MeSH
- Check Tag
- Humans MeSH
- Male MeSH
- Female MeSH
- Publication type
- Clinical Trial MeSH
Autoři na souboru 45 pacientů s histologicky doloženou sarkoidózou sledovali hladinu sIL2R, rozsah postižení (generalizované versus plicní postižení), funkční poruchu plic a jednotlivá stadia onemocnění u nově diagnostikovaných pacientů ve vztahu k hodnotě SACE a k počtu Ly v BALTe. Prokázali statisticky významnou korelaci mezi hladinou sIL2R a SACE a také mezi sIL2R a počtem Ly v BALTe. Zjistili, že v jejich souboru pacientů byla přítomna vyšší senzitivita než u sIL2R jenom u poměru CD4+/CD8+, což ukazuje na význam kombinace všech těchto metod při diagnostice aktivní sarkoidózy.
A group of 45 patients with histologically confirmed sarcoidosis was used to observe the level of sIL2R, extent of involvement (generalized vs. pulmonary involvement), functional impairment of the lungs and individual stages of the disease in newly diagnosed patients, in relation to the SACE level and the number of Ly in BALF. A statistically significant correlation was found between the levels of sIL2R and SACE and also between sIL2R and the number of Ly in BALF. In this group of patients, only the CD4+/CD8+ ratio showed higher sensitivity than sIL2R, suggesting that all those methods should be combined in diagnosing active sarcoidosis.
- MeSH
- Analysis of Variance MeSH
- Angiotensins chemistry blood MeSH
- Biomarkers chemistry blood metabolism MeSH
- Enzyme-Linked Immunosorbent Assay methods utilization MeSH
- Enzymes chemistry blood MeSH
- Data Interpretation, Statistical MeSH
- Receptors, Interleukin-2 isolation & purification blood MeSH
- Sarcoidosis etiology immunology blood MeSH
- Severity of Illness Index MeSH
- MeSH
- Common Variable Immunodeficiency diagnosis complications therapy MeSH
- gamma-Globulins therapeutic use MeSH
- Comorbidity MeSH
- Humans MeSH
- Prednisone administration & dosage therapeutic use MeSH
- Sarcoidosis diagnosis complications therapy MeSH
- Check Tag
- Humans MeSH
- Publication type
- Case Reports MeSH
Z údajov Národného registra tuberkulózy a Národného onkologického registra Slovenskej republiky vyplýva, že v rokoch 1995-1999 bolo v ÚTPCHaHCH Vyšné Hágy hospitalizovaných 65 pacientov, u ktorých boli tieto dve ochorenia hlásené. Zisťujeme, že reálna koincidencia týchto ochorení je takmer 15-násobne vyššia ako teoreticky vypočítaná z hlásení NRT a NOR SR, pričom najčastejšie postihnutou skupinou sú muži nad 60 rokov. V tomto súbore sa podarilo dosiahnuť 100 % debacilizáciu TB. Z práce vyplýva, že pacienti so zhubnými nádormi sú potencionálne rizikovou skupinou pre vznik tuberkulózy a tiež, že je potrebné zasielať opravy v hláseniach a kontrolné hlásenia do NRT
According to the National tuberculosis register and the National cancer register of Slovak republic in the period from 1995 to 1999, 65 patients with these two disease were hospitalised in the Institute of Tuberculosis, Lung Diseases and Thoracic Surgery in Vysne Hagy. The real coincidence of these both diseases is about 15 times higher like a theoretical calculated occurence. In this cohort of patients a 100 % tuberculosis debacilization was achieved. Men above 60 years of age are the most affected group of population according our results. In conclusion lung patients with cancer are potencional risk group for occurens tuberculosis.
- MeSH
- Adult MeSH
- Disease Notification MeSH
- Hospitalization MeSH
- Incidence MeSH
- Middle Aged MeSH
- Humans MeSH
- Lung Neoplasms diagnosis epidemiology therapy MeSH
- Registries MeSH
- Aged MeSH
- Tuberculosis diagnosis epidemiology therapy MeSH
- Check Tag
- Adult MeSH
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Publication type
- Review MeSH
- Comparative Study MeSH
- Geographicals
- Slovakia MeSH
