• MeSH
• Eye Abnormalities etiology   pathology   prevention & control   therapy   MeSH
• Diagnostic Techniques, Ophthalmological MeSH
• Cataract * etiology   pathology   therapy   congenital   MeSH
• Humans MeSH
• Infant, Newborn MeSH
• Neonatal Screening * methods   MeSH
• Prognosis MeSH
• Check Tag
• Humans MeSH
• Infant, Newborn MeSH
• Publication type
• Review MeSH

PURPOSE: To determine the central corneal thickness (CCT) in microphthalmic aphakic or pseudophakic eyes as well as in microphthalmic eyes without any history of eye surgery. METHODS: Thirty-two patients with a mean age of 6.41±5.24 years after congenital cataract surgery with absolute microcornea, i.e., horizontal corneal diameter (HCD)<10 mm, or relative microcornea, i.e., HCD 10-11 mm but in the affected eye at least 0.5 mm smaller compared to the fellow eye, formed group A. Thirteen patients of mean age 0.94±1.22 years with absolute or relative microcornea plus another developmental anomaly of an eye without any history of eye surgery formed group B. The patients with corneal edema or scars were excluded. The control group consisted of 124 healthy school-aged children. Horizontal corneal diameter was measured with caliper and CCT with an ultrasound pachymeter. In infants, these measurements were performed under general anesthesia. RESULTS: In 48 eyes in group A and in 16 eyes in group B, the mean CCT was 635.13±65.35 µm and 642.31±93.07 µm, respectively, which was significantly greater (p<0.0001 and p=0.0018) in comparison with the mean CCT (553.58±33.12 µm) in the control group. Regression curve demonstrated the significant increase of CCT values along with the decrease of HCD in microphthalmic eyes. CONCLUSIONS: Small corneas in microphthalmic eyes either with or without congenital cataract surgery have significantly higher CCT. The results demonstrate significant negative correlation between horizontal corneal diameter and CCT.

• MeSH
• Aphakia, Postcataract pathology   MeSH
• Diagnostic Techniques, Ophthalmological MeSH
• Child MeSH
• Cataract Extraction MeSH
• Cataract congenital   MeSH
• Infant MeSH
• Humans MeSH
• Microphthalmos pathology   MeSH
• Child, Preschool MeSH
• Pseudophakia pathology   MeSH
• Cornea abnormalities   pathology   MeSH
• Check Tag
• Child MeSH
• Infant MeSH
• Humans MeSH
• Male MeSH
• Child, Preschool MeSH
• Female MeSH
• Publication type
• Journal Article MeSH

V průběhu trvání projektu bude skenovací laserovou polarimetrií (SLP) vyšetřena kontrolní skupina nejméně 360 zdravých dětí ve věku 8-17 roků a stanovena tak normativní databáze parametrů vrstvy nervových vláken sítnice (RNFL) v této věkové skupině. Zároveň bude nejméně 40 dětí stejného stáří léčených pro glaukom opakovaně vyšetřeno rovněž pomocí SLP a zjištěné parametry RNFL budou porovnány s referenčními hodnotami zdravé populace stejné věkové skupiny. Předběžná analýza bude provedena po 2 letech a definitivní na konci studie. Dále bude sledován vývoj parametrů RNFL u pacientů s glaukomem po celou dobu projektu a zkoumán vztah ke kompenzaci. Bude provedena korelace parametrů RNFL se stupněm glaukomového poškození na terči zrakového nervu a v zorném poli pacientů a zkoumán vývoj těchto změn v průběhu celého projektu.; A control group of at least 360 sound children at age of 8-17 years will be examined by SLP between 2005 and 2009 to creat the normative database of the RNFL parameters for this age group. At the same time at least of 40 children with glaucoma will be examined repeatedly (min.twice a year) by SLP for comparison of their RNFL parameters with normative database to detect the glaucomatous damage. The changes of the RNFL parameters during the 5 years will be analysed with regard to clinical control of the disease. Preliminary analysis is planned in the beginning of the third study year and final statistics at the end of the project. The corellation between the RNFL parameters and the extent of the glaucomatous damage on the optic nerve head and in the visual field will be also studied.

• MeSH
• Diagnostic Techniques, Ophthalmological MeSH
• Child MeSH
• Glaucoma MeSH
• Retinal Neurons MeSH
• Ocular Hypertension diagnosis   MeSH
• Data Collection MeSH
• Scanning Laser Polarimetry MeSH
• Congenital Abnormalities MeSH
• Check Tag
• Child MeSH

• Conspectus
• Ortopedie. Chirurgie. Oftalmologie
• NML Fields
• oftalmologie
• pediatrie
• radiologie, nukleární medicína a zobrazovací metody
• NML Publication type
• závěrečné zprávy o řešení grantu IGA MZ ČR

PURPOSE: To investigate the occurrence and features of the atypical birefringence pattern (ABP) images in scanning laser polarimetry with variable corneal compensation (GD×VCC) in healthy children and to assess their impact on the values of the retinal nerve fiber layer (RNFL) thickness. METHODS: GD×VCC scans in 120 healthy white school-aged children with mean age ± standard deviation (SD) 12.85 ± 3.0 years were evaluated using typical scan score (TSS) calculation and by subjective grading of the scans. Statistical analysis including the impact of ABP on the RNFL thickness in GD × VCC Temporal-Superior-Nasal-Inferior-Temporal (TSNIT) parameters was done. RESULTS: The ABP was found in 18 out of 120 patients (15%) at cut-off value of TSS <80. Subjective evaluation of the scans raised the frequency of ABP to 20% of patients. The mean ± SD values of TSNIT Average, Superior Average, and Inferior Average in 26 eyes with ABP versus 214 eyes with normal birefringence pattern were 66.99 ± 7.29 μm versus 58.00 ± 6.22 μm (P = 7.2E to -11), 78.43 ± 9.27 μm versus 72.33 ± 8.72 μm (P = 0.001) and 80.87 ± 12.01 μm versus 70.00 ± 10.20 μm (P = 0.000001), respectively. The same comparison in TSNIT SD showed minimal difference and was 25.42 ± 5.84 μm versus 26.41 ± 4.81 μm (P = 0.41). CONCLUSIONS: The occurrence of ABP in children is not rare and may significantly distort the measured values of the RNFL thickness in TSNIT parameters using GD × VCC.

• MeSH
• Artifacts MeSH
• Optic Disk anatomy & histology   MeSH
• Child MeSH
• Birefringence MeSH
• Humans MeSH
• Nerve Fibers MeSH
• Refraction, Ocular physiology   MeSH
• Retinal Ganglion Cells cytology   MeSH
• Cornea physiology   MeSH
• Sex Factors MeSH
• Scanning Laser Polarimetry MeSH
• Tonometry, Ocular MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Male MeSH
• Female MeSH
• Publication type
• Journal Article MeSH
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Child MeSH
• Filtering Surgery methods   utilization   MeSH
• Financing, Organized MeSH
• Glaucoma surgery   MeSH
• Humans MeSH
• Ophthalmologic Surgical Procedures methods   trends   utilization   MeSH
• Check Tag
• Child MeSH
• Humans MeSH

• MeSH
• Diagnostic Techniques, Ophthalmological classification   utilization   MeSH
• Child MeSH
• Financing, Organized MeSH
• Glaucoma epidemiology   etiology   MeSH
• Humans MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Male MeSH
• Female MeSH

To assess the normative data of the retinal nerve fiber layer (RNFL) thickness in healthy children using the scanning laser polarimeter with variable corneal compensation (GDxVCC). METHODS: Of the 186 enrolled white school-aged children, 120 subjects of the mean 12.85 +/- 3.0 years (age +/- SD) fulfilled inclusion criteria. After complete ophthalmic examination, including GDxVCC, 240 normal eyes were analyzed. Evaluation of RNFL thickness in GDxVCC temporal-superior-nasal-inferior-temporal (TSNIT) parameters was performed, and probability of normality was calculated. The influence of sex and age was investigated. RESULTS: The mean +/- SD values in TSNIT Average, Superior Average, Inferior Average, and TSNIT SD were 58.98 +/- 6.92 microm, 72.99 +/- 8.97 microm, 71.18 +/- 10.92 microm, and 26.30 +/- 4.92 microm. The values of 5% probability of normality in the same order were 47.6 microm, 58.2 microm, 53.2 microm, and 18.2 microm. The mean values of Inferior Average and TSNIT SD were greater in left eyes by 1.84 +/- 6.6 microm (p = 0.003) and by 3.04 +/- 3.8 microm (p < 0.00005), respectively. No correlation to sex and age was found. CONCLUSIONS: RNFL thickness assessed using GDxVCC was greater in children compared with previous published data in healthy adults. The values of Inferior Average and TSNIT SD were significantly greater in left eyes.

• MeSH
• Diagnostic Techniques, Ophthalmological MeSH
• Child MeSH
• Birefringence MeSH
• Lasers diagnostic use   MeSH
• Humans MeSH
• Adolescent MeSH
• Nerve Fibers ultrastructure   MeSH
• Image Processing, Computer-Assisted MeSH
• Probability MeSH
• Reference Values MeSH
• Retina anatomy & histology   MeSH
• Cornea physiology   MeSH
• Check Tag
• Child MeSH
• Humans MeSH
• Adolescent MeSH
• Publication type
• Research Support, Non-U.S. Gov't MeSH

• MeSH
• Child MeSH
• Research Support as Topic MeSH
• Glaucoma diagnosis   MeSH
• Lasers diagnostic use   MeSH
• Humans MeSH
• Tomography, Optical Coherence MeSH
• Prospective Studies MeSH
• Check Tag
• Child MeSH
• Humans MeSH

• Publication type
• Meeting Abstract MeSH